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Dose Range Finding Study to Assess Efficacy and Safety of Tozorakimab in Adults With Uncontrolled Asthma on Medium-to-High Dose Inhaled Corticosteroids
Sponsor: AstraZeneca
Summary
This is a dose-range finding, double-blind, placebo-controlled, phase IIb study designed to assess efficacy and safety of tozorakimab administered subcutaneously in adult participants with uncontrolled asthma receiving medium-to-high dose inhaled corticosteroids.
Official title: A Phase IIb, Multicentre, Double-blind, Placebo-controlled Dose Range Finding Study to Assess Efficacy and Safety of Tozorakimab in Adult Participants With Uncontrolled Asthma on Medium-to High Dose Inhaled Corticosteroids
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
540
Start Date
2025-03-26
Completion Date
2028-02-28
Last Updated
2026-10-30
Healthy Volunteers
No
Conditions
Interventions
Tozorakimab
The drug will be administered subcutaneously.
Placebo
Placebo will be administered subcutaneously.
Locations (223)
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Bakersfield, California, United States
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Huntington Beach, California, United States
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La Mesa, California, United States
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Loma Linda, California, United States
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Long Beach, California, United States
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Newport Beach, California, United States
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San Jose, California, United States
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Wilmington, Delaware, United States
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Cutler Bay, Florida, United States
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Hialeah, Florida, United States
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Leesburg, Florida, United States
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Miami, Florida, United States
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Miami, Florida, United States
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Miami Lakes, Florida, United States
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Orlando, Florida, United States
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Palmetto Bay, Florida, United States
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Tampa, Florida, United States
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Winter Park, Florida, United States
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Boise, Idaho, United States
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Noblesville, Indiana, United States
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West Des Moines, Iowa, United States
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Hutchinson, Kansas, United States
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Kansas City, Kansas, United States
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Louisville, Kentucky, United States
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White Marsh, Maryland, United States
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Worcester, Massachusetts, United States
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Farmington Hills, Michigan, United States
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Warren, Michigan, United States
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St Louis, Missouri, United States
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Bellevue, Nebraska, United States
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Grand Island, Nebraska, United States
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Omaha, Nebraska, United States
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Millville, New Jersey, United States
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Mullica Hill, New Jersey, United States
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Toms River, New Jersey, United States
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Horseheads, New York, United States
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Maspeth, New York, United States
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Asheville, North Carolina, United States
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Huntersville, North Carolina, United States
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Kings Mountain, North Carolina, United States
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Pinehurst, North Carolina, United States
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Toledo, Ohio, United States
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Edmond, Oklahoma, United States
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Grants Pass, Oregon, United States
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Medford, Oregon, United States
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Portland, Oregon, United States
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DuBois, Pennsylvania, United States
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Philadelphia, Pennsylvania, United States
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Smithfield, Pennsylvania, United States
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Rock Hill, South Carolina, United States
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Knoxville, Tennessee, United States
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Austin, Texas, United States
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Boerne, Texas, United States
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Dallas, Texas, United States
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El Paso, Texas, United States
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Forney, Texas, United States
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Greenville, Texas, United States
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Kingwood, Texas, United States
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McKinney, Texas, United States
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Sugar Land, Texas, United States
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Victoria, Texas, United States
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Roy, Utah, United States
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Bellingham, Washington, United States
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Kingwood, West Virginia, United States
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Milwaukee, Wisconsin, United States
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CABA, Argentina
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Ciudad de Buenos Aires, Argentina
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Ciudad de Buenos Aires, Argentina
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La Plata, Argentina
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Mendoza, Argentina
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Rosario, Argentina
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San Miguel de Tucumán, Argentina
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Caxias do Sul, Brazil
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Criciúma, Brazil
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Porto Alegre, Brazil
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Porto Alegre, Brazil
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Salvador, Brazil
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Santo André, Brazil
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São José do Rio Preto, Brazil
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São Paulo, Brazil
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São Paulo, Brazil
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Sorocaba, Brazil
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Curicó, Chile
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Quillota, Chile
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Santiago, Chile
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Santiago, Chile
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Santiago, Chile
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Temuco, Chile
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Viña del Mar, Chile
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Baotou, China
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Changchun, China
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Chengdu, China
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Chongqing, China
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Guangzhou, China
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Haikou, China
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Hefei, China
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Hohhot, China
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Huizhou, China
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Qingdao, China
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Shanghai, China