Clinical Research Directory
Browse clinical research sites, groups, and studies.
Exploratory Study of Personalized mRNA Vaccine in Patients With Refractory Rhabdomyosarcoma
Sponsor: Xinxin Zhang
Summary
An Exploratory Study on the Use of mRNA Tumor Vaccines in the Treatment of Refractory Rhabdomyosarcoma
Key Details
Gender
All
Age Range
6 Years - Any
Study Type
INTERVENTIONAL
Enrollment
5
Start Date
2025-10-13
Completion Date
2028-05-01
Last Updated
2026-10-26
Healthy Volunteers
No
Conditions
Interventions
personalized neoantigen mRNA vaccine
During the vaccine manufacturing period and prior to the first vaccine administration, patients may continue their prior antitumor regimen in combination with the study drugs (toripalimab and the CpG-1018 adjuvant), at the investigator's discretion and based on patient preference. Once vaccine manufacturing is complete, the personalized neoantigen mRNA vaccine will be administered as monotherapy, and all prior antitumor treatments will be discontinued.
Locations (1)
Chinese PLA General Hospital
Beijing, Beijing Municipality, China