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RECRUITING
NCT06932861
EARLY_PHASE1

Exploratory Study of Personalized mRNA Vaccine in Patients With Refractory Rhabdomyosarcoma

Sponsor: Xinxin Zhang

View on ClinicalTrials.gov

Summary

An Exploratory Study on the Use of mRNA Tumor Vaccines in the Treatment of Refractory Rhabdomyosarcoma

Key Details

Gender

All

Age Range

6 Years - Any

Study Type

INTERVENTIONAL

Enrollment

5

Start Date

2025-10-13

Completion Date

2028-05-01

Last Updated

2026-10-26

Healthy Volunteers

No

Interventions

BIOLOGICAL

personalized neoantigen mRNA vaccine

During the vaccine manufacturing period and prior to the first vaccine administration, patients may continue their prior antitumor regimen in combination with the study drugs (toripalimab and the CpG-1018 adjuvant), at the investigator's discretion and based on patient preference. Once vaccine manufacturing is complete, the personalized neoantigen mRNA vaccine will be administered as monotherapy, and all prior antitumor treatments will be discontinued.

Locations (1)

Chinese PLA General Hospital

Beijing, Beijing Municipality, China