Clinical Research Directory
Browse clinical research sites, groups, and studies.
A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue
Sponsor: Pfizer
Summary
Study to investigate the efficacy, safety and tolerability of systemic chemotherapy plus ponsegromab versus systemic chemotherapy plus placebo for the first-line treatment in adult participants with cachexia and metastatic pancreatic ductal adenocardinoma.
Official title: A Phase 2b/3, Randomized, Double-Blind Study to Investigate the Efficacy, Safety, and Tolerability of Ponsegromab (PF-06946860) Compared With Placebo Both With Background First-Line Chemotherapy in Adult Participants With Cachexia and Metastatic Pancreatic Ductal Adenocarcinoma
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
982
Start Date
2025-10-03
Completion Date
2029-12-24
Last Updated
2026-10-14
Healthy Volunteers
No
Interventions
ponsegromab
Double-Blind ponsegromab Treatment
placebo
Double-Blind placebo Treatment
Locations (230)
The Kirklin Clinic of UAB Hospital
Birmingham, Alabama, United States
The University of Alabama at Birmingham
Birmingham, Alabama, United States
Mayo Clinic Hospital
Phoenix, Arizona, United States
Central Arkansas Radiation Therapy Institute, dba CARTI
Bryant, Arkansas, United States
Central Arkansas Radiation Therapy Institute, dba CARTI
Conway, Arkansas, United States
CARTI Cancer Center
Little Rock, Arkansas, United States
Central Arkansas Radiation Therapy Institute, dba CARTI
North Little Rock, Arkansas, United States
Central Arkansas Radiation Therapy Institute, dba CARTI
Pine Bluff, Arkansas, United States
UC San Diego Medical Center - Encinitas
Encinitas, California, United States
Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine, California, United States
UCI Health - Irvine
Irvine, California, United States
UC San Diego Koman Family Outpatient Pavilion
La Jolla, California, United States
UC San Diego Medical Center - La Jolla (Jacobs Medical Center / Thornton Pavilion)
La Jolla, California, United States
UC San Diego Moores Cancer Center
La Jolla, California, United States
UC San Diego Sulpizio Cardiovascular Center
La Jolla, California, United States
Cedars-Sinai Cancer at Cedars-Sinai Medical Center
Los Angeles, California, United States
UCLA Department of Medicine - Hematology/Oncology
Los Angeles, California, United States
UC Irvine Health
Orange, California, United States
UC San Diego Medical Center - Bankers Hill
San Diego, California, United States
UC San Diego McGrath Outpatient Pavilion - Hillcrest
San Diego, California, United States
UC San Diego Medical Center - Hillcrest
San Diego, California, United States
UC San Diego Medical Center - Rancho Bernardo
San Diego, California, United States
UCLA Hematology/Oncology - Santa Monica
Santa Monica, California, United States
Providence Medical Foundation
Santa Rosa, California, United States
UC San Diego Medical Center - Vista
Vista, California, United States
Georgetown University Medical Center - Department of Pharmacy, Oncology Pharmacy
Washington D.C., District of Columbia, United States
Georgetown University Medical Center
Washington D.C., District of Columbia, United States
Mayo Clinic Pharmacy
Jacksonville, Florida, United States
Mayo Clinic
Jacksonville, Florida, United States
University Cancer & Blood Center, LLC
Athens, Georgia, United States
Invision, LLC
Honolulu, Hawaii, United States
University of Hawaii Cancer Center
Honolulu, Hawaii, United States
Cardiology Associates, Inc
‘Aiea, Hawaii, United States
Cancer Care Specialists of Illinois
Decatur, Illinois, United States
Decatur Memorial Hospital
Decatur, Illinois, United States
Hope and Healing Clinical Research LLC
Hinsdale, Illinois, United States
Hope and Healing Clinical Research LLC New Lenox- Research Department
New Lenox, Illinois, United States
Cancer Care Specialists of Illinois - Cancer Care Center of O'Fallon
O'Fallon, Illinois, United States
United Imaging Consultants
Lenexa, Kansas, United States
MidAmerica Cancer Care- American Oncology Partners
Merriam, Kansas, United States
University of Kentucky Research Foundation
Lexington, Kentucky, United States
University of Kentucky Healthcare - Markey Cancer Center
Lexington, Kentucky, United States
University of Kentucky Medical Center
Lexington, Kentucky, United States
University of Kentucky, Markey Cancer Center Clinical Research Office (UK MCC CRO)
Lexington, Kentucky, United States
JHU Oncology Central Kit Services
Baltimore, Maryland, United States
Johns Hopkins Hospital
Baltimore, Maryland, United States
Oncology Investigational Drug Service (IDS)
Baltimore, Maryland, United States
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore, Maryland, United States
Mayo Clinic Cancer Center Outpatient Pharmacy
Rochester, Minnesota, United States
Mayo Clinic
Rochester, Minnesota, United States
Premier Imaging
Kansas City, Missouri, United States
St. Joseph Medical Center
Kansas City, Missouri, United States
MidAmerica Cancer Care - American Oncology Partners
Kansas City, Missouri, United States
Nebraska Medicine
Omaha, Nebraska, United States
Nebraska Medicine - Village Pointe
Omaha, Nebraska, United States
University of Nebraska Medical Center
Omaha, Nebraska, United States
Renown Health Medical Oncology
Reno, Nevada, United States
Renown Office of Clinical Research
Reno, Nevada, United States
Renown Regional Medical Center
Reno, Nevada, United States
Atlantic Health System / Morristown Medical Center
Morristown, New Jersey, United States
Jack & Sheryl Morris Cancer Center
New Brunswick, New Jersey, United States
Rutgers Cancer Institute
New Brunswick, New Jersey, United States
RWJ University Hospital Somerset, Steeplechase Cancer Center
Somerville, New Jersey, United States
Rwj University Hospital Somerset
Somerville, New Jersey, United States
Atlantic Health System / Overlook Medical Center
Summit, New Jersey, United States
Icahn School of Medicine at Mount Sinai
New York, New York, United States
University of Rochester Medical Center
Rochester, New York, United States
UNC Hospitals, The University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States
Levine Cancer Institute
Charlotte, North Carolina, United States
University of North Carolina Hospitals at Hillsborough
Hillsborough, North Carolina, United States
OHSU Center for Health & Healing 1
Portland, Oregon, United States
Oregon Health and Science University
Portland, Oregon, United States
OSHU Center for Health and Healing 2
Portland, Oregon, United States
Henry-Joyce Cancer Clinic
Nashville, Tennessee, United States
University of Texas Southwestern Medical Center - Simmons Cancer Center
Dallas, Texas, United States
University of Texas Southwestern Medical Center-William P. Clements Jr. University Hospital
Dallas, Texas, United States
University of Texas Southwestern Medical Center-Zale Lipshy University Hospital
Dallas, Texas, United States
University of Texas Southwestern Medical Center
Dallas, Texas, United States
Houston Methodist Hospital
Houston, Texas, United States
Baylor Scott & White Vasicek Cancer Treatment Center
Temple, Texas, United States
VCU Medical Center Gateway Building
Richmond, Virginia, United States
Virginia Commonwealth University
Richmond, Virginia, United States
VCU Health Short Pump Pavilion
Richmond, Virginia, United States
VCU Health Stony Point
Richmond, Virginia, United States
Massey Cancer Center Clinical & Translational Research Lab
Richmond, Virginia, United States
Virginia Commonwealth University
Richmond, Virginia, United States
VCU Health Tappahannock Hospital
Tappahannock, Virginia, United States
Virginia Mason Medical Center
Seattle, Washington, United States
Fred Hutchinson Cancer Center
Seattle, Washington, United States
University of Washington Medical Center
Seattle, Washington, United States
Froedtert Hospital and the Medical College of Wisconsin
Milwaukee, Wisconsin, United States
Shoalhaven District Memorial Hospital
Nowra, New South Wales, Australia
Westmead Hospital
Westmead, New South Wales, Australia
ICON Cancer Centre - Kurralta Park
Kurralta Park, South Australia, Australia
Icon Cancer Centre Hobart
Hobart, Tasmania, Australia
Western Health-Sunshine & Footscray Hospitals
St Albans, Victoria, Australia
AZ Turnhout - Campus Sint-Elizabeth
Turnhout, Antwerpen, Belgium
Cliniques universitaires Saint-Luc
Brussels, Bruxelles-capitale, Région de, Belgium
Grand Hôpital de Charleroi
Charleroi, Hainaut, Belgium
UZ Leuven
Leuven, Vlaams-brabant, Belgium