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A Study Comparing Tarlatamab, Durvalumab, Carboplatin, and Etoposide Versus Durvalumab, Carboplatin, and Etoposide in First-line Extensive Stage Small-Cell Lung Cancer (ES-SCLC)
Sponsor: Amgen
Summary
The main objective of the study is to compare the efficacy of tarlatamab in combination with durvalumab, carboplatin and etoposide to the combination of durvalumab, carboplatin and etoposide on prolonging overall survival (OS).
Official title: A Phase 3, Open Label, Multicenter, Randomized Study of First Line Tarlatamab in Combination With Durvalumab, Carboplatin and Etoposide Versus Durvalumab, Carboplatin and Etoposide in Untreated Extensive Stage Small-Cell Lung Cancer (DeLLphi-312)
Key Details
Gender
All
Age Range
18 Years - 99 Years
Study Type
INTERVENTIONAL
Enrollment
350
Start Date
2025-08-18
Completion Date
2029-08-15
Last Updated
2026-09-08
Healthy Volunteers
No
Interventions
Tarlatamab
Tarlatamab will be administered as an intravenous (IV) infusion.
Durvalumab
Durvalumab will be administered as an IV infusion.
Carboplatin
Carboplatin will be administered as an IV infusion.
Etoposide
Etoposide will be administered as an IV infusion.
Locations (164)
Cancer and Blood Specialists of Arizona
Casa Grande, Arizona, United States
City of Hope Cancer Center Phoenix
Goodyear, Arizona, United States
Genesis Cancer Center
Hot Springs, Arkansas, United States
Saint Bernards Medical Center
Jonesboro, Arkansas, United States
Providence Saint Jude Medical Center
Fullerton, California, United States
Translational Research in Oncology US Inc, Trio Central Pharmacy
Los Angeles, California, United States
University of California Los Angeles
Santa Monica, California, United States
Presbyterian Intercommunity Hospital Health Whitter Hospital
Whittier, California, United States
Colorado West Healthcare System dba Grand Valley Oncology
Grand Junction, Colorado, United States
Hartford HealthCare Cancer Institute at The Hospital of Central Connecticut
New Britain, Connecticut, United States
Yale New Haven Hospital
New Haven, Connecticut, United States
Eastern Connecticut Hematology and Oncology Associates
Norwich, Connecticut, United States
Florida Oncology and Hematology
Fort Myers, Florida, United States
Cancer Specialists of North Florida - Southpoint
Jacksonville, Florida, United States
Orlando Health Cancer Institute
Kissimmee, Florida, United States
Central Georgia Cancer Care PC
Macon, Georgia, United States
City of Hope Atlanta
Newnan, Georgia, United States
University of Illinois Chicago
Chicago, Illinois, United States
Cancer Care Specialists of Illinois
Decatur, Illinois, United States
Midwestern Regional Medical Center dba City of Hope Chicago
Rockford, Illinois, United States
Indiana University Melvin and Bren Simon Cancer Center
Indianapolis, Indiana, United States
Hematology Oncology of Indiana
Indianapolis, Indiana, United States
Cancer Center of Kansas, Heritage Plaza Medical Building
Wichita, Kansas, United States
New England Cancer Specialists
Westbrook, Maine, United States
Dana Farber Cancer Institute
Boston, Massachusetts, United States
Minnesota Oncology Hematology PA
Edina, Minnesota, United States
Allina Health System dba Allina Health Cancer Institute
Minneapolis, Minnesota, United States
Mayo Clinic
Rochester, Minnesota, United States
Hattiesburg Clinic Hematology/Oncology
Hattiesburg, Mississippi, United States
Cancer Partners of Nebraska
Lincoln, Nebraska, United States
Nebraska Cancer Specialists
Omaha, Nebraska, United States
New York Oncology Hematology PC
Albany, New York, United States
Hematology Oncology Association of Central New York
East Syracuse, New York, United States
New York Cancer and Blood Specialists
Shirley, New York, United States
Oncology Hematology Care, Inc
Cincinnati, Ohio, United States
University Hospitals Cleveland Medical Center
Cleveland, Ohio, United States
Willamette Valley Cancer Institute and Research Center - Eugene
Eugene, Oregon, United States
Kaiser Permanente Medical Center
Portland, Oregon, United States
Baptist Cancer Center
Memphis, Tennessee, United States
United States Oncology Regulatory Affairs Corporate Office
Nashville, Tennessee, United States
Texas Oncology - Dallas Fort Worth
Dallas, Texas, United States
Oncology Consultants
Houston, Texas, United States
US Oncology Research Investigational Products Center
Irving, Texas, United States
University of Texas Health Science Center at Tyler
Tyler, Texas, United States
Texas Oncology - Northeast Texas
Tyler, Texas, United States
Virginia Cancer Specialists PC
Fairfax, Virginia, United States
Virginia Oncology Associates
Norfolk, Virginia, United States
Swedish Cancer Institute Medical Oncology
Seattle, Washington, United States
Northwest Medical Specialties, PLLC
Tacoma, Washington, United States
West Virginia University Health Sciences Center
Morgantown, West Virginia, United States
Cemic
Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
Hospital Universitario Austral
Pilar, Buenos Aires, Argentina
Sanatorio Parque SA
Rosario, Santa Fe Province, Argentina
Chris OBrien Lifehouse
Camperdown, New South Wales, Australia
Monash Medical Centre
Clayton, Victoria, Australia
Medizinische Universitaet Graz
Graz, Austria
Universitaetsklinikum Krems
Krems, Austria
Jessa Ziekenhuis - Campus Virga Jesse
Hasselt, Belgium
Universitair Ziekenhuis Leuven - Campus Gasthuisberg
Leuven, Belgium
AZ Delta Campus Rumbeke
Roeselare, Belgium
Centre Hospitalier Universitaire-Universite Catholique de Louvain Namur-Site Godinne
Yvoir, Belgium
Cenantron Centro Avançado de Tratamento Oncologico Ltda
Belo Horizonte, Minas Gerais, Brazil
Liga Norte-Riograndense Contra O Cancer
Natal, Rio Grande do Norte, Brazil
Hospital Sao Lucas da Pontificia Universidade Catolica do Rio Grande do Sul
Porto Alegre, Rio Grande do Sul, Brazil
Fund Faculdade Regional Med Sao Jose Rio Preto
São José do Rio Preto, São Paulo, Brazil
Centro de Pesquisa do Hospital Albert Einstein
São Paulo, São Paulo, Brazil
Beijing Cancer Hospital
Beijing, Beijing Municipality, China
Beijing Cancer Hospital
Beijing, Beijing Municipality, China
The Second Attached Hospital Of Fujian Medical University
Quanzhou, Fujian, China
Harbin Medical University Cancer Hospital
Harbin, Heilongjiang, China
Jiamusi Cancer Hospital
Jiamusi, Heilongjiang, China
Henan Cancer Hospital
Zhengzhou, Henan, China
Jiangxi Cancer hospital
Nanchang, Jiangxi, China
The First Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, China
Shandong Cancer Hospital
Jinan, Shandong, China
Shanghai Chest Hospital
Shanghai, Shanghai Municipality, China
Shanghai Pulmonary Hospital
Shanghai, Shanghai Municipality, China
Shanxi Provincial Cancer Hospital
Taiyuan, Shanxi, China
West China Hospital of Sichuan University
Chengdu, Sichuan, China
Tianjin Cancer Hospital
Tianjin, Tianjin Municipality, China
Tianjin Peoples Hospital
Tianjin, Tianjin Municipality, China
The First Affiliated Hospital Of Ningbo University
Ningbo, Zhejiang, China
Fujian Cancer Hospital
Fuzhou, China
Rigshospitalet
Copenhagen, Denmark
Regionshospitalet Godstrup
Herning, Denmark
Centre Hospitalier Intercommunal de Creteil
Créteil, France
Centre Leon Berard
Lyon, France
Centre Hospitalier Universitaire Nord
Marseille, France
Institut Curie
Paris, France
Centre Hospitalier Universitaire de Nantes - Hopital Nord Laennec
Saint-Herblain, France
Hopital d instruction des armees sainte anne
Toulon, France
Centre Hospitalier Universitaire de Toulouse - Hopital Larrey
Toulouse, France
Klinikum Chemnitz GmbH
Chemnitz, Germany
Krankenhaus Koeln-Merheim - Kliniken der Stadt Koeln gGmbH
Cologne, Germany
Universitaetsklinikum Dresden
Dresden, Germany
Universitaetsklinikum Essen
Essen, Germany
Krankenhaus Nordwest
Frankfurt am Main, Germany
Asklepios Fachkliniken Muenchen Gauting
Gauting, Germany
LungenClinic Grosshansdorf GmbH
Großhansdorf, Germany
Universitaetsklinikum Schleswig-Holstein - Kiel
Kiel, Germany