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Real-world Study on Liver Cancer Risk in Chronic Hepatitis B Patients With Family History of Liver Cancer
Sponsor: Peking University First Hospital
Summary
This study is a prospective, multicenter, real-world cohort study designed to compare the long-term outcomes of chronic hepatitis B patients with a family history of HBV-related hepatocellular carcinoma (HCC) who receive PEG IFNα-2b combined with nucleos(t)ide analogues or nucleos(t)ide monotherapy. The primary endpoint is the incidence rate of HCC, and secondary endpoints include the rate of HBsAg seroclearance, changes in liver fibrosis, and survival rates. The study will last for 5 years and enroll approximately 15,000 patients, aiming to provide evidence-based optimization for CHB treatment regimens.
Official title: A Real-World Study on Reducing the Risk of Liver Cancer in Chronic Hepatitis B Patients With a Family History of HBV-Related Liver Cancer.
Key Details
Gender
All
Age Range
30 Years - Any
Study Type
OBSERVATIONAL
Enrollment
1500
Start Date
2025-06
Completion Date
2032-12
Last Updated
2025-06-05
Healthy Volunteers
No
Interventions
ETV,TDF,TAF,TMF combination with PEG IFNα-2b
The study will not involve any additional interventions, nor will it interfere with any related clinical decision-making.
ETV,TDF,TAF or TMF
The study will not involve any additional interventions, nor will it interfere with any related clinical decision-making.
Locations (555)
Qitaihe Infectious Disease Hospital
Heilongjiang, Heilongjiang, China
Yizheng People's Hospital
Yizheng, Jiangsu, China
Changle County People's Hospital
Changle, Shandong, China
Juxian People's Hospital
Junxian, Shandong, China
Pingdu People's Hospital, Shandong
Pingdu, Shandong, China
Zouping People's Hospital
Zouping, Shandong, China
Huozhou Coal & Electricity Group General Hospital Co., Ltd.
Huozhou, Shanxi, China
Huozhou People's Hospital, Huozhou Medical Group
Huozhou, Shanxi, China
Huozhou People's Hospital
Huozhou, Shanxi, China
Fenxi Mining Group Employees General Hospital
Jiexiu, Shanxi, China
Jiexiu Medical Group People's Hospital
Jiexiu, Shanxi, China
Anfu County People's Hospital
Anfu, China
Ankang Central Hospital
Ankang, China
Ankang Hospital of Traditional Chinese Medicine
Ankang, China
Anning Hospital of Traditional Chinese Medicine
Anning, China
Anqing First People's Hospital
Anqing, China
Anqing Municipal Hospital
Anqing, China
Anshan Infectious Disease Hospital
Anshan, China
Anyue County People's Hospital
Anyue, China
Affiliated Hospital of Youjiang Medical University for Nationalities
Baise City, China
Baoding First Central Hospital
Baoding, China
Baoding People's Hospital
Baoding, China
Baotou Central Hospital
Baotou, China
China National Medicines (CNM) Northern Hospital
Baotou, China
The Third Staff Hospital of Baotou Steel Group
Baotou, China
Beihai People's Hospital
Beihai, China
Beijing Daxing District People's Hospital
Beijing, China
Beijing Ditan Hospital, Capital Medical University
Beijing, China
Beijing Ditan Hospital
Beijing, China
Beijing Fangshan District First Hospital
Beijing, China
Beijing Hospital of Traditional Chinese Medicine, Capital Medical University
Beijing, China
Beijing Huaxin Hospital
Beijing, China
Beijing Liangxiang Hospital, Fangshan District
Beijing, China
Beijing Tsinghua Changgung Hospital
Beijing, China
Beijing You'an Hospital, Capital Medical University
Beijing, China
Beijing You'an Hospital
Beijing, China
Dongfang Hospital, Beijing University of Chinese Medicine
Beijing, China
Dongzhimen Hospital, Beijing University of Chinese Medicine
Beijing, China
Peking University People's Hospital
Beijing, China
Peking University Third Hospital
Beijing, China
Shunyi Hospital of Traditional Chinese Medicine, Beijing
Beijing, China
The Fifth Medical Center of PLA General Hospital
Beijing, China
Wangfu Hospital of Integrated Traditional Chinese and Western Medicine
Beijing, China
Xiyuan Hospital, China Academy of Chinese Medical Sciences
Beijing, China
Xuanwu Hospital, Capital Medical University
Beijing, China
Bengbu Fifth People's Hospital
Bengbu, China
Guzhen County Hospital of Traditional Chinese Medicine
Bengbu, China
Guzhen County People's Hospital
Bengbu, China
The First Affiliated Hospital of Bengbu Medical University
Bengbu, China
Benxi Sixth People's Hospital
Benxi, China
Beihai Tuberculosis Prevention and Treatment Hospital
Bihua, China
Binzhou Central Hospital
Binzhou, China
Binzhou People's Hospital
Binzhou, China
Bozhou Hospital of Traditional Chinese Medicine
Bozhou, China
Bozhou People's Hospital
Bozhou, China
Lixin County People's Hospital
Bozhou, China
Mengcheng First People's Hospital
Bozhou, China
Cangzhou Third Hospital
Cangzhou, China
The First Hospital of Jilin University
Changchun, China
Changji Branch of the First Affiliated Hospital of Xinjiang Medical University
Changji, China
Changji Hui Autonomous Prefecture People's Hospital
Changji, China
Changxing County People's Hospital
Changxing, China
Changzhi People's Hospital
Changzhi, China
Heping Hospital Affiliated to Changzhi Medical College
Changzhi, China
Changzhou Third People's Hospital
Changzhou, China
Yizheng People's Hospital
Changzhou, China
Chaoyang Fourth Hospital
Chaoyang, China
Kazuo County Central Hospital
Chaoyang, China
Chengdu Fifth People's Hospital
Chengdu, China
Chengdu Public Health Clinical Medical Center
Chengdu, China
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
Chengdu, China
West China Hospital, Sichuan University
Chengdu, China
Chifeng Baoshan Hospital
Chifeng, China
Chifeng Songshan Traditional Chinese Medicine & Mongolian Medicine Hospital
Chifeng, China
Chifeng Tumor Hospital
Chifeng, China
Chizhou People's Hospital
Chizhou, China
Mingguang People's Hospital
Chuzhou, China
Dali Bai Autonomous Prefecture People's Hospital
Dali, China
The First Affiliated Hospital of Dalian Medical University
Dalian, China
Dandong Sixth People's Hospital
Dandong, China
Daqing Second Hospital
Daqing, China
China National Medicines & Health Products Datong Coal Mine Group General Hospital
Datong, China
Datong Fourth People's Hospital
Datong, China
Donggang Central Hospital
Donggang, China
Dongguan Eastern Central Hospital
Dongguan, China
Dongguan Ninth People's Hospital
Dongguan, China
Dongtai People's Hospital
Dongtai, China
Dongying Hospital of Traditional Chinese Medicine
Dongying, China
Dongying People's Hospital
Dongying, China
Shengli Oilfield Central Hospital
Dongying, China
Jianshi County People's Hospital
Enshi, China
Lichuan Traditional Chinese Medicine Hospital for Ethnic Minorities
Enshi, China
Ezhou Central Hospital
Ezhou, China
Fengcheng People's Hospital
Fengcheng, China
Fenyang Hospital
Fenyang, China
Foshan Hospital of Traditional Chinese Medicine
Foshan, China
Sanshui Hospital of Zhujiang Hospital, Southern Medical University
Foshan, China
Shunde Hospital Affiliated to Jinan University
Foshan, China
The Eighth Affiliated Hospital of Southern Medical University
Foshan, China
The Fourth People's Hospital of Foshan
Foshan, China