Clinical Research Directory
Browse clinical research sites, groups, and studies.
Study of Casdatifan and Cabozantinib Versus Placebo and Cabozantinib in Patients With Advanced Clear Cell Renal Cell Carcinoma
Sponsor: Arcus Biosciences, Inc.
Summary
The purpose of the study is to evaluate the progression-free survival (PFS) of casdatifan versus placebo when each is given in combination with cabozantinib for patients who received anti-PD-1 or anti-PD-L1 therapy as part of the most recent regimen (either adjuvant monotherapy or first-line in combination with anti-CTLA-4 or VEGFR-TKI), with no more than 1 prior regimen in the metastatic setting.
Official title: A Randomized, Double-Blind, Active-Control, Multicenter Phase 3 Trial of Casdatifan and Cabozantinib Versus Placebo and Cabozantinib in Patients With Advanced Clear Cell Renal Cell Carcinoma
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
720
Start Date
2025-09-08
Completion Date
2030-12
Last Updated
2026-11-02
Healthy Volunteers
No
Interventions
Casdatifan
Administered as specified in the treatment arm
Cabozantinib
Administered as specified in the treatment arm
Placebo
Administered as specified in the treatment arm
Locations (191)
Research Site
Gilbert, Arizona, United States
Research Site
Goodyear, Arizona, United States
Research Site
Phoenix, Arizona, United States
Research Site
Duarte, California, United States
Research Site
Irvine, California, United States
Research Site
La Jolla, California, United States
Research Site
Los Angeles, California, United States
Research Site
Palo Alto, California, United States
Research Site
Sacramento, California, United States
Research Site
San Diego, California, United States
Research Site
Aurora, Colorado, United States
Research Site
New Haven, Connecticut, United States
Research Site
Washington D.C., District of Columbia, United States
Research Site
Jacksonville, Florida, United States
Research Site
Miami, Florida, United States
Research Site
Orlando, Florida, United States
Research Site
Atlanta, Georgia, United States
Research Site
Atlanta, Georgia, United States
Research Site
Newnan, Georgia, United States
Research Site
Zion, Illinois, United States
Research Site
Indianapolis, Indiana, United States
Research Site
Louisville, Kentucky, United States
Research Site
Jefferson, Louisiana, United States
Research Site
Baltimore, Maryland, United States
Research Site
Boston, Massachusetts, United States
Research Site
Boston, Massachusetts, United States
Research Site
Rochester, Minnesota, United States
Research Site
St Louis, Missouri, United States
Research Site
Omaha, Nebraska, United States
Research Site
New Brunswick, New Jersey, United States
Research Site
Buffalo, New York, United States
Research Site
New York, New York, United States
Research Site
Rochester, New York, United States
Research Site
Chapel Hill, North Carolina, United States
Research Site
Durham, North Carolina, United States
Research Site
Cleveland, Ohio, United States
Research Site
Portland, Oregon, United States
Research Site
Monroeville, Pennsylvania, United States
Research Site
Charleston, South Carolina, United States
Research Site
Nashville, Tennessee, United States
Research Site
Nashville, Tennessee, United States
Research Site
Dallas, Texas, United States
Research Site
Lubbock, Texas, United States
Research Site
Salt Lake City, Utah, United States
Research Site
Charlottesville, Virginia, United States
Research Site
Seattle, Washington, United States
Research Site
Buenos Aires, Argentina
Research Site
Córdoba, Argentina
Research Site
La Plata, Argentina
Research Site
Pilar, Argentina
Research Site
Rosario, Argentina
Research Site
Viedma, Argentina
Research Site
Box Hill, Australia
Research Site
Chermside, Australia
Research Site
Elizabeth Vale, Australia
Research Site
Frankston, Australia
Research Site
Frenchs Forest, Australia
Research Site
Heidelberg, Australia
Research Site
Hobart, Australia
Research Site
Kurralta Park, Australia
Research Site
Macquarie Park, Australia
Research Site
New South Wales, Australia
Research Site
South Brisbane, Australia
Research Site
St Albans, Australia
Research Site
Subiaco, Australia
Research Site
Westmead, Australia
Research Site
Calgary, Canada
Research Site
Edmonton, Canada
Research Site
Hamilton, Canada
Research Site
London, Canada
Research Site
Montreal, Canada
Research Site
Sherbrooke, Canada
Research Site
Toronto, Canada
Research Site
Vancouver, Canada
Research Site
Brno, Czechia
Research Site
Brno-střed, Czechia
Research Site
České Budějovice, Czechia
Research Site
Hradec, Czechia
Research Site
Prague, Czechia
Research Site
Angers, France
Research Site
Brest, France
Research Site
Caen, France
Research Site
Clermont-Ferrand, France
Research Site
Lille, France
Research Site
Marseille, France
Research Site
Montpellier, France
Research Site
Paris, France
Research Site
Pessac, France
Research Site
Poitiers, France
Research Site
Reims, France
Research Site
Rennes, France
Research Site
Strasbourg, France
Research Site
Toulouse, France
Research Site
Villejuif, France
Research Site
Berlin, Germany
Research Site
Dresden, Germany
Research Site
Essen, Germany
Research Site
Frankfurt, Germany
Research Site
Freiburg im Breisgau, Germany
Research Site
Halle, Germany