Clinical Research Directory
Browse clinical research sites, groups, and studies.
A Study of Long-acting Antibodies Alone and in Combinations for Moderate to Severe Ulcerative Colitis
Sponsor: Spyre Therapeutics, Inc.
Summary
This is a Phase 2, multicenter, proof-of-concept platform study in adult participants with moderately to severely active ulcerative colitis (UC). The primary goal of the study is to assess the efficacy and safety of multiple interventions following intravenous (IV) induction and subcutaneous (SC) maintenance treatment.
Official title: Phase 2 Platform Trial to Assess the Efficacy and Safety of Long-acting Antibodies as Single Agents and in Combinations for Moderately to Severely Active Ulcerative Colitis
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
645
Start Date
2025-05-27
Completion Date
2028-03
Last Updated
2026-10-27
Healthy Volunteers
No
Interventions
SPY001
Experimental
SPY002
Experimental
SPY003
Experimental
Placebo
Placebo
Locations (276)
Site 024
Canoga Park, California, United States
Site 023
La Jolla, California, United States
Site 012
Lancaster, California, United States
Site 033
Colorado Springs, Colorado, United States
Site 007
Kissimmee, Florida, United States
029
Miami, Florida, United States
Site 038
Chicago, Illinois, United States
Site 006
Kansas City, Kansas, United States
Site 030
Louisville, Kentucky, United States
Site 035
Marrero, Louisiana, United States
Site 011
Glen Burnie, Maryland, United States
Site 003
Boston, Massachusetts, United States
Site 028
Rochester, Minnesota, United States
Site 039
St Louis, Missouri, United States
Site 037
New York, New York, United States
040
Chapel Hill, North Carolina, United States
Site 041
Durham, North Carolina, United States
Site 016
Winston-Salem, North Carolina, United States
Site 025
Providence, Rhode Island, United States
Site 017
Kingsport, Tennessee, United States
Site 013
Cedar Park, Texas, United States
Site 005
Garland, Texas, United States
Site 002
San Antonio, Texas, United States
Site 008
Southlake, Texas, United States
Site 009
Webster, Texas, United States
Site 004
Seattle, Washington, United States
Site 019
Tacoma, Washington, United States
Site 105
La Plata, Buenos Aires, Argentina
Site 102
Lujan de Cuyo, Mendoza Province, Argentina
Site 103
Rosario, Sant Fe, Argentina
Site 104
San Miguel de Tucumán, Tucumán Province, Argentina
Site 201
Murdoch, Western Australia, Australia
Site 208
Concord, Australia
Site 202
Heidelberg, Australia
Site 204
Liverpool, Australia
Site 203
Melbourne, Australia
Site 206
South Brisbane, Australia
Site 207
Woolloongabba, Australia
Site 463
Linz, Austria
Site 476
Ghent, Osst-Vlaanderen, Belgium
Site 474
Sint-Niklaas, Osst-Vlaanderen, Belgium
Site 475
Bruges, Belgium
Site 471
Ghent, Belgium
Site 472
Roeselare, Belgium
Site 481
Banja Luka, Bosnia and Herzegovina
Site 484
Mostar, Bosnia and Herzegovina
Site 483
Sarajevo, Bosnia and Herzegovina
Site 123
Brasília, Federal District, Brazil
Site 133
Goiânia, Goiás, Brazil
Site 136
Juiz de Fora, Minas Gerais, Brazil
Site 137
Teresina, Piauí, Brazil
Site 125
Caxias do Sul, Rio Grande do Sul, Brazil
Site 134
Passo Fundo, Rio Grande do Sul, Brazil
Site 126
Passo Fundo, Rio Grande do Sul, Brazil
Site 122
Porto Alegre, Rio Grande do Sul, Brazil
Site 121
Porto Alegre, Rio Grande do Sul, Brazil
Site 135
Barretos, São Paulo, Brazil
Site 131
Campinas, São Paulo, Brazil
Site 129
Consolação, São Paulo, Brazil
Site 138
Jaú, São Paulo, Brazil
Site 128
Santo André, São Paulo, Brazil
Site 127
Santos, São Paulo, Brazil
Site 130
São José do Rio Preto, São Paulo, Brazil
Site 132
São Paulo, Brazil
Site 124
São Paulo, Brazil
Site 494
Gorna Oryahovitsa, Bulgaria
Site 498
Rousse, Bulgaria
Site 492
Sofia, Bulgaria
Site 499
Sofia, Bulgaria
Site 495
Sofia, Bulgaria
Site 083
London, Ontario, Canada
Site 084
Toronto, Ontario, Canada
Site 082
Chicoutimi, Quebec, Canada
Site 087
Montreal, Quebec, Canada
Site 081
Montreal, Quebec, Canada
Site 085
Greater Sudbury, Canada
Site 086
London, Canada
Site 153
Osorno, Los Lagos Region, Chile
Site 152
Santiago, Santiago Metropolitan, Chile
Site 521
Osijek, Croatia
Site 524
Zagreb, Croatia
Site 531
Brno, Czechia
Site 536
Klatovy, Czechia
Site 534
Ostrava, Czechia
Site 537
Pardubice, Czechia
Site 538
Prague, Czechia
Site 555
Marseille, France
Site 551
Nantes, France
Site 557
Nice, France
Site 556
Pierre-Bénite, France
Site 558
Saint-Etienne, France
Site 584
Kutaisi, Georgia
Site 589
Marneuli, Georgia
Site 581
Tbilisi, Georgia
Site 588
Tbilisi, Georgia
Site 583
Tbilisi, Georgia
Site 586
Tbilisi, Georgia
Site 582
Tbilisi, Georgia
Site 587
Tbilisi, Georgia
Site 590
Tbilisi, Georgia