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An Open Label Clinical Study to Evaluate Tanruprubart (Also Commonly Known as ANX005) in Participants With Guillain-Barré Syndrome (FORWARD Study)
Sponsor: Annexon, Inc.
Summary
The goal of this open label study is to measure pharmacokinetics, pharmacodynamics, early efficacy, and safety of tanruprubart in adult and pediatric participants, in the United States, Canada, and Europe.
Official title: An Open-Label Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Efficacy, and Safety of a Single Dose of ANX005 in Participants With Guillain-Barré Syndrome
Key Details
Gender
All
Age Range
8 Years - 85 Years
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2025-09-12
Completion Date
2028-06-30
Last Updated
2026-10-26
Healthy Volunteers
No
Conditions
Interventions
Tanruprubart
Solution for IV infusion.
Locations (30)
St. Joseph's Hospital & Medical Center - Barrow Neurological Institute (Dignity Health)
Phoenix, Arizona, United States
HonorHealth Bob Bové Neuroscience Institute
Scottsdale, Arizona, United States
Profound Research LLC
Carlsbad, California, United States
Loma Linda
Loma Linda, California, United States
Children's Hospital of Orange County
Orange, California, United States
University of California Irvine
Orange, California, United States
Stanford University
Palo Alto, California, United States
University of Colorado Hospital
Aurora, Colorado, United States
Georgetown
Washington D.C., District of Columbia, United States
Mayo Clinic Florida
Jacksonville, Florida, United States
University of Kansas Medical Center
Kansas City, Kansas, United States
Ochsner LSU Health
Shreveport, Louisiana, United States
University Massachusetts Chan Medical School
Worcester, Massachusetts, United States
University of Michigan
Ann Arbor, Michigan, United States
Henry Ford Health
Detroit, Michigan, United States
Mayo Rochester
Rochester, Minnesota, United States
Dartmouth Hitchcock Medical Center
Lebanon, New Hampshire, United States
Albany Medical Center
Albany, New York, United States
Duke University
Durham, North Carolina, United States
Cleveland Clinic
Cleveland, Ohio, United States
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States
University of Virginia Department of Neurology
Charlottesville, Virginia, United States
Aarhus University Hospital
Aarhus, Aarhus N, Denmark
Righospitalet - Copenhagen Neuromuscular Center
Østerbro, Copenhagen, Denmark
Hospital Bicêtre
Le Kremlin-Bicêtre, Cedex, France
Hospital Universitario de Bellvitge
L'Hospitalet de Llobregat, Barcelona, Spain
Hospital Universitario Infanta Sofia
San Sebastián de los Reyes, Madrid, Spain
Queen Elizabeth Hospital
Edgbaston, Birmingham, United Kingdom
Queen Elizabeth University Hospital
Glasgow, United Kingdom
University of Oxford - West Wing John Radcliffe Hospital
Oxford, United Kingdom