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This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.
Sponsor: Pfizer
Summary
This study will explore whether a combination of the investigational drug mevrometostat (PF-06821497) and enzalutamide will work better than taking enzalutamide alone in participants with mCSPC who are ARPI naïve and have not yet received chemotherapy in the mCSPC setting.
Official title: A PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF MEVROMETOSTAT (PF-06821497) WITH ENZALUTAMIDE IN METASTATIC CASTRATION-SENSITIVE PROSTATE CANCER (MEVPRO-3)
Key Details
Gender
MALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
1000
Start Date
2025-09-28
Completion Date
2034-12-08
Last Updated
2026-10-14
Healthy Volunteers
No
Conditions
Interventions
Mevrometostat
Oral continuous
Placebo
Oral continuous
Enzalutamide
Oral continuous
Locations (319)
Clearview Cancer Institute (Crestwood)
Huntsville, Alabama, United States
Clearview Cancer Institute
Huntsville, Alabama, United States
Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers
Chandler, Arizona, United States
Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers
Gilbert, Arizona, United States
Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers
Glendale, Arizona, United States
Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers
Goodyear, Arizona, United States
Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers
Mesa, Arizona, United States
Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers
Mesa, Arizona, United States
Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers
Phoenix, Arizona, United States
Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers
Scottsdale, Arizona, United States
Highlands Oncology Group, PA
Fayetteville, Arkansas, United States
Highlands Oncology Group, PA
Rogers, Arkansas, United States
Highlands Oncology Group, PA
Springdale, Arkansas, United States
UCLA Hematology/Oncology - Alhambra
Alhambra, California, United States
UCLA Hematology/Oncology - Atascadero
Atascadero, California, United States
Cedars-Sinai Cancer Beverly Hills (drug treatment and dispensing location)
Beverly Hills, California, United States
Cedars-Sinai Cancer Beverly Hills
Beverly Hills, California, United States
UCLA Hematology/Oncology - Beverly Hills
Beverly Hills, California, United States
UCLA Hematology/Oncology - Burbank
Burbank, California, United States
UCLA Hematology/Oncology - Encino
Encino, California, United States
UCLA Hematology/Oncology - Irvine
Irvine, California, United States
UCLA Hematology/Oncology - Laguna Hills
Laguna Hills, California, United States
Cedars-Sinai Cancer at Cedars-Sinai Medical Center
Los Angeles, California, United States
Ronald Reagan UCLA Medical Center - Drug Information Center
Los Angeles, California, United States
UCLA Department of Medicine - Hematology/Oncology
Los Angeles, California, United States
UCLA Hematology/Oncology
Los Angeles, California, United States
UCLA Hematology/Oncology - Marina del Rey
Marina del Rey, California, United States
UCLA Hematology/Oncology - Pasadena
Pasadena, California, United States
UCLA Hematology/Oncology - Porter Ranch
Porter Ranch, California, United States
UCLA Hematology/Oncology - San Luis Obispo
San Luis Obispo, California, United States
UCLA Hematology/Oncology - Santa Barbara
Santa Barbara, California, United States
UCLA Hematology/Oncology- Santa Monica
Santa Monica, California, United States
UCLA Hematology/Oncology - Torrance
Torrance, California, United States
UCLA Hematology/Oncology - Santa Clarita
Valencia, California, United States
UCLA Hematology/Oncology - Ventura
Ventura, California, United States
UCLA Hematology/Oncology - Westlake
Westlake Village, California, United States
AdventHealth Medical Group Urology of Denver
Denver, Colorado, United States
Advanced Urology Institute, LLC
Largo, Florida, United States
Tennessee Oncology, PLLC - Dalton
Dalton, Georgia, United States
Tennessee Oncology, PLLC - Ringgold
Ringgold, Georgia, United States
Associated Urological Specialists - Chicago Ridge
Chicago Ridge, Illinois, United States
Cancer Care Specialists of Illinois
Decatur, Illinois, United States
Cancer Care Specialists of Illinois
O'Fallon, Illinois, United States
Michigan Institute of Urology, PC
Troy, Michigan, United States
MSK Basking Ridge
Basking Ridge, New Jersey, United States
MSK Monmouth
Middletown, New Jersey, United States
MSK Bergen
Montvale, New Jersey, United States
MSK Commack
Commack, New York, United States
MSKCC-Westchester (500 Westchester Ave.)
Harrison, New York, United States
Integrated Medical Professionals
Lake Success, New York, United States
Memorial Sloan Kettering Cancer Center (IDS Pharmacy)
Long Island City, New York, United States
Evelyn H. Lauder Breast and Imaging Center (BAIC).
New York, New York, United States
Memorial Sloan Kettering Cancer Center - Main Campus
New York, New York, United States
Sidney Kimmel Center for Prostate and Urological Cancers - Memorial Sloan Kettering Cancer Center
New York, New York, United States
University of Rochester Medical Center
Rochester, New York, United States
University of Rochester, Cancer Center Pharmacy (Investigational Product)
Rochester, New York, United States
Integrated Medical Professionals
Seaford, New York, United States
Montefiore Einstein Comprehensive Cancer Center
The Bronx, New York, United States
Montefiore Medical Center- Montefiore Medical Park
The Bronx, New York, United States
MSK Nassau.
Uniondale, New York, United States
Duke Cancer Center Cary
Cary, North Carolina, United States
Duke University Medical Center (location of scans)
Durham, North Carolina, United States
Duke University Medical Center - Duke Cancer Center
Durham, North Carolina, United States
Duke University Medical Center - Duke University Hospital (location of scans)
Durham, North Carolina, United States
Duke University
Durham, North Carolina, United States
Duke Cancer Center Raleigh
Raleigh, North Carolina, United States
Duke Raleigh Hospital
Raleigh, North Carolina, United States
Duke Women's Cancer Care Raleigh (Pharmacy location and location of CT, MRI and Bone scan machines)
Raleigh, North Carolina, United States
University Hospitals Seidman Cancer Center at UH Avon Health Center
Avon, Ohio, United States
TriState Urologic Services PSC Inc. dba The Urology Group
Cincinnati, Ohio, United States
University Hospitals Cleveland Medical Center
Cleveland, Ohio, United States
University Hospitals Seidman Cancer Center at UH Mentor Health Center
Mentor, Ohio, United States
UH Minoff Health Center at Chagrin Highlands
Orange, Ohio, United States
OU Health Medical Center
Oklahoma City, Oklahoma, United States
OU Health Stephenson Cancer Center
Oklahoma City, Oklahoma, United States
MidLantic urology
Bala-Cynwyd, Pennsylvania, United States
The Centers for Advanced Urology d/b/a Keystone Urology Specialist
Lancaster, Pennsylvania, United States
Grand Strand Medical Center
Myrtle Beach, South Carolina, United States
Carolina Urologic Research Center, LLC
Myrtle Beach, South Carolina, United States
Parkway Surgery Center
Myrtle Beach, South Carolina, United States
Tennessee Oncology, PLLC - Chattanooga Downtown
Chattanooga, Tennessee, United States
Tennessee Oncology PLLC
Chattanooga, Tennessee, United States
Tennessee Oncology, PLLC - Chattanooga Med Park II
Chattanooga, Tennessee, United States
Tennessee Oncology, PLLC - Chattanooga Memorial
Chattanooga, Tennessee, United States
Tennessee Oncology, PLLC - Chattanooga East
Chattanooga, Tennessee, United States
Tennessee Oncology, PLLC - Cleveland
Cleveland, Tennessee, United States
Tennessee Oncology, PLLC - Cookeville
Cookeville, Tennessee, United States
Tennessee Oncology, PLLC - Dickson
Dickson, Tennessee, United States
Tennessee Oncology, PLLC - Franklin
Franklin, Tennessee, United States
Tennessee Oncology, PLLC - Gallatin
Gallatin, Tennessee, United States
The West Clinic, PLLC dba West Cancer Center
Germantown, Tennessee, United States
Tennessee Oncology Hendersonville
Hendersonville, Tennessee, United States
Tennessee Oncology, PLLC - Lebanon
Lebanon, Tennessee, United States
Tennessee Oncology, PLLC - Mount Juliet
Mount Juliet, Tennessee, United States
Tennessee Oncology, PLLC - Murfreesboro
Murfreesboro, Tennessee, United States
Tennessee Oncology, PLLC - Investigational Drug Services
Nashville, Tennessee, United States
Tennessee Oncology, PLLC - Nashville Elliston Place Plaza Medical Oncology & Hematology Clinic
Nashville, Tennessee, United States
Tennessee Oncology, PLLC - Nashville Saint Thomas West
Nashville, Tennessee, United States
Tennessee Oncology, PLLC - Nashville Skyline
Nashville, Tennessee, United States
Urology Associates, P.C.
Nashville, Tennessee, United States