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Single Intravitreal (IVT) Injection of 4D-150 in Patients With Macular Neovascularization Secondary to Age-Related Macular Degeneration
Sponsor: 4D Molecular Therapeutics
Summary
This Phase 3 study is evaluating the safety and efficacy of 4D-150 versus aflibercept in participants with neovascular age-related macular degeneration (nAMD). Enrollment in the primary global cohort has been completed; Study centers in Japan remain open for enrollment for the Japan cohort.
Official title: A Phase 3, Randomized, Double-Masked, Active-Controlled Trial of a Single Intravitreal Injection of 4D-150 in Adults With Macular Neovascularization Secondary to Age-Related Macular Degeneration
Key Details
Gender
All
Age Range
50 Years - Any
Study Type
INTERVENTIONAL
Enrollment
480
Start Date
2025-07-22
Completion Date
2029-11
Last Updated
2026-10-19
Healthy Volunteers
No
Interventions
4D-150 IVT (3E10 vg/eye)
If randomized to the 4D-150 treatment arm, 4D-150 will be administered at the assigned dose level as a single dose IVT injection on Day 1
EYLEA® (aflibercept) Injection 2 mg (0.05mL)
Eylea (aflibercept) will be administered at applicable visits
Locations (126)
Research Network Arizona
Scottsdale, Arizona, United States
Barnet Dulaney Perkins Eye Center
Sun City, Arizona, United States
Retina Associates
Tucson, Arizona, United States
Retinal Diagnostic Center
Campbell, California, United States
Retina Consultants of Orange County
Fullerton, California, United States
Northern California Retina Vitreous Associates
Mountain View, California, United States
Retinal Consultants Medical Group Inc.
Sacramento, California, United States
Retinal Consultants Medical Group
Sacramento, California, United States
West Coast Retina Medical Group
San Francisco, California, United States
Bay Area Retina Associates
Walnut Creek, California, United States
Retina Consultants of Southern Colorado P.C.
Colorado Springs, Colorado, United States
Retina Specialists of Colorado
Denver, Colorado, United States
Southwest Retina Consultants
Durango, Colorado, United States
ClearVista Clinical Research
Hudson, Florida, United States
Florida Retina Consultants
Lakeland, Florida, United States
Florida Retina Institute
Orlando, Florida, United States
Retina Specialty Institute
Pensacola, Florida, United States
Retina Vitreous Associates of Florida
St. Petersburg, Florida, United States
East Florida Eye Institute
Stuart, Florida, United States
Retina Vitreous Associates of Florida
Tampa, Florida, United States
Thomas Eye Group
Sandy Springs, Georgia, United States
Retina Associates, Ltd.
Elmhurst, Illinois, United States
University Retina and Macula Associates, PC
Oak Forest, Illinois, United States
Illinois Retina Associates
Oak Park, Illinois, United States
Springfield Clinic
Springfield, Illinois, United States
Retina Partners Midwest, PC
Carmel, Indiana, United States
Haik Humble Eye Center
West Monroe, Louisiana, United States
The Retina Care Center
Baltimore, Maryland, United States
Cumberland Valley Retina Consultants
Hagerstown, Maryland, United States
Mid Atlantic Retina Specialists
Hagerstown, Maryland, United States
New England Retina Consultants
Springfield, Massachusetts, United States
Foundation for Vision Research
Grand Rapids, Michigan, United States
The Retina Institute
St Louis, Missouri, United States
Sierra Eye Associates
Reno, Nevada, United States
Envision Ocular, LLC
Bloomfield, New Jersey, United States
Retina Vitreous Surgeons of CNY PC
Liverpool, New York, United States
New York Presbyterian Hospital - Columbia University Medical Center
New York, New York, United States
Vitreoretinal Consultants of NY
Westbury, New York, United States
North Carolina Retina Associates
Cary, North Carolina, United States
North Carolina Retina Associates
Wake Forest, North Carolina, United States
Cincinnati Eye Institute
Cincinnati, Ohio, United States
Verum Research, LLC
Eugene, Oregon, United States
EyeHealth Northwest
Portland, Oregon, United States
Erie Retina Research
Erie, Pennsylvania, United States
Charleston Neuroscience Institute, LLC
Bluffton, South Carolina, United States
Carolina Eyecare Physicians
Mt. Pleasant, South Carolina, United States
Palmetto Retina Center
West Columbia, South Carolina, United States
Black Hills Regional Eye Institute
Rapid City, South Dakota, United States
Southeastern Retina Associates
Johnson City, Tennessee, United States
Tennessee Retina, PC
Nashville, Tennessee, United States
Southwest Retina Specialist - Panhandle Eye group, LLP
Amarillo, Texas, United States
Austin Clinical Research
Austin, Texas, United States
Texas Retina Associate
Dallas, Texas, United States
Austin Retina Associates
San Marcos, Texas, United States
Tyler Retina Consultants
Tyler, Texas, United States
Strategic Clinical Research
Willow Park, Texas, United States
Rocky Mountain Retina Consultants
Salt Lake City, Utah, United States
Piedmont Eye Center
Lynchburg, Virginia, United States
Pacific Northwest Retina
Silverdale, Washington, United States
Eye Clinic of Wisconsin
Wausau, Wisconsin, United States
Centro Privado de Ojos Romagosa
Córdoba, Córdoba Province, Argentina
IMOC
Córdoba, Córdoba Province, Argentina
Grupo Láser Visión
Rosario, Santa Fe Province, Argentina
Microcirugia Ocular Rosario
Rosario, Santa Fe Province, Argentina
Hospital Britanico de Buenos Aires
Buenos Aires, Argentina
Centro Privado de Ojos
Buenos Aires, Argentina
Charles Research Center
Buenos Aires, Argentina
OFTALMOS
Buenos Aires, Argentina
Centrovisión
Mendoza, Argentina
Centro de la Vision
Salta, Argentina
IZBA Inv Clinica
Salta, Argentina
Adelaide Eye and Retina Centre
Adelaide, Australia
Eye Clinic Albury Wodonga
Albury, Australia
Strathfield Retina Clinic
Strathfield, Australia
Sydney Retina Clinic and Day Surgery
Sydney, Australia
Zora Eye Hospital
Sofia, Bulgaria
CHU de Nice - Hopital Pasteur 2
Nice, PACA, France
Centre Paradis Monticelli
Marseille, France
Clinique Jules Verne
Nantes, France
Internationale Innovative Ophthalmochirurgie GbR
Düsseldorf, Germany
Augenzentrum Frankfurt
Frankfurt, Germany
Dietrich Bonhoeffer Klinikum
Neubrandenburg, Germany
Bajcsy-Zsilinszky Kórház
Budapest, Hungary
Budapest Retina Associates
Budapest, Hungary
Semmelweis Egyetem - Szemészeti Klinika
Budapest, Hungary
DE KK Ophthalmology Clinic
Debrecen, Hungary
Ganglion Medical Center
Pécs, Hungary
SzTE SZAKK Szemeszeti Klinika
Szeged, Hungary
Rambam Health Care Campus
Haifa, Israel
Carmel Medical Center
Haifa, Israel
Wolfson Medical Center
Holon, Israel
Shaare Zedek Medical Center
Jerusalem, Israel
Hadassah Medical Center Ein-Kerem
Jerusalem, Israel
Sheba Medical Center
Ramat Gan, Israel
Kaplan Medical Center
Rehovot, Israel
Tel Aviv Medical Center
Tel Aviv, Israel
AOU delle Marche
Ancona, Italy
Nagoya University Hospital
Nagoya, Aichi-ken, Japan
Hyogo Prefectural Amagasaki General Medical Center
Hyōgo, Amagasaki-Shi, Japan
Fukushima Medical University Hospital
Fukushima, Fukushima, Japan