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A Research Study to See How a Weekly Insulin, Insulin Icodec, Helps in Reducing the Blood Sugar Compared to Daily Insulin Glargine, Both in Combination With Insulin Aspart, in Adults With Type 1 Diabetes
Sponsor: Novo Nordisk A/S
Summary
This study compares insulin icodec, an insulin taken once a week to insulin glargine, an insulin taken once a day. The study medicine will be investigated in participants with type 1 diabetes. The study will look at how well insulin icodec taken weekly controls blood sugar compared to insulin glargine taken daily. The study will last for about 8.5 months.
Official title: A 26-week Study Comparing the Efficacy and Safety of Once-weekly Insulin Icodec and Once-daily Insulin Glargine U100, Both in Combination With Insulin Aspart, in Adults With Type 1 Diabetes
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
877
Start Date
2025-08-11
Completion Date
2027-03-01
Last Updated
2026-09-25
Healthy Volunteers
No
Conditions
Interventions
Insulin icodec
Insulin icodec will be administered as subcutaneous injection
Insulin glargine
Insulin glargine will be administered as subcutaneous injection.
Insulin aspart
Insulin aspart will be administered as a subcutaneous injection.
Locations (182)
Cullman Clinical Trials
Cullman, Alabama, United States
John Muir Health
Concord, California, United States
Headlands Research California, LLC
Escondido, California, United States
Clinical Res of Central Ca
Fresno, California, United States
Providence Medical Foundation
Fullerton, California, United States
Scripps Whittier Diabetes Inst
La Jolla, California, United States
Loma Linda University Faculty Medical Clinics
Loma Linda, California, United States
Pacific Clinical Studies
Los Alamitos, California, United States
Los Angeles Institute for Metabolic Research
Los Angeles, California, United States
Pasadena Clinical Trials
Pasadena, California, United States
WestenU Health
Pomona, California, United States
Alliance Clinical Network
San Diego, California, United States
Mills Health Center
San Mateo, California, United States
Center for Endocrine DM and Metabolic Disorders
Santa Clarita, California, United States
University Clin Investigators
Tustin, California, United States
Diablo Clinical Research, Inc.
Walnut Creek, California, United States
Denver Endocrinology Diabetes and Thyroid Center
Englewood, Colorado, United States
Optumcare Clinical Trials,LLC-Golden
Golden, Colorado, United States
Northeast Research Institute
Fleming Island, Florida, United States
Encore Medical Research LLC
Hollywood, Florida, United States
Northeast Research Institute
Jacksonville, Florida, United States
Life Spring Research Foundation LLC
Miami, Florida, United States
Suncoast Clinical Research, Inc.
New Port Richey, Florida, United States
West Orange Endocrinology
Ocoee, Florida, United States
Suncoast Clinical Research, Inc.
Palm Harbor, Florida, United States
Center for Diab,Obes & Metab
Pembroke Pines, Florida, United States
SRA Trials-Broward
Pembroke Pines, Florida, United States
Hanson Clinical Research Center
Port Charlotte, Florida, United States
Latin Clinical Trial Ctr
Tamarac, Florida, United States
Bayside Clinical Research
Tampa, Florida, United States
Metabolic Research Institute Inc
West Palm Beach, Florida, United States
Atlanta Diabetes Associates
Atlanta, Georgia, United States
Centricity Research Columbus
Columbus, Georgia, United States
Physicians Research Assoc. LLC
Lawrenceville, Georgia, United States
Endocrine Research Solutions, Inc
Roswell, Georgia, United States
Rocky Mt Clin Res, LLC
Idaho Falls, Idaho, United States
Northwestern University
Chicago, Illinois, United States
University Of Chicago
Chicago, Illinois, United States
Endeavor Health
Skokie, Illinois, United States
Indiana Uni School of Med-Ped
Indianapolis, Indiana, United States
Iowa Diabetes Research
West Des Moines, Iowa, United States
Cotton O'Neil Diabetes & Endocrinology
Topeka, Kansas, United States
Robley Rex VA Medical Center
Louisville, Kentucky, United States
MedStar Health Research Institute
Olney, Maryland, United States
Brigham & Women's Hospital
Boston, Massachusetts, United States
Profound Research LLC
Clarkston, Michigan, United States
Profound Research LLC
Farmington Hills, Michigan, United States
Elite Clinical Research Center
Flint, Michigan, United States
International Diabetes Center
Minneapolis, Minnesota, United States
Mayo Clinic
Rochester, Minnesota, United States
Saint Louis University
St Louis, Missouri, United States
Washington University
St Louis, Missouri, United States
QCR Network
Omaha, Nebraska, United States
University of Nebraska Medical Center
Omaha, Nebraska, United States
Palm Research Center Inc.
Las Vegas, Nevada, United States
Albuquerque Clinical Trials Inc.
Albuquerque, New Mexico, United States
AMC Community Endocrinology
Albany, New York, United States
NYC Research, Inc.
New York, New York, United States
NYU Langone Orthopedic Center
New York, New York, United States
University at Buffalo
Williamsville, New York, United States
Physicians East Endocrinology
Greenville, North Carolina, United States
Centricity Rsrch MHCity Multi
Morehead City, North Carolina, United States
Centricity Res New Bern Multispeciality
New Bern, North Carolina, United States
Accellacare of Raleigh
Raleigh, North Carolina, United States
Accellacare Wilmington
Wilmington, North Carolina, United States
Diab & Endo Assoc of Stark Co
Canton, Ohio, United States
Cleveland Clinic_Cleveland
Cleveland, Ohio, United States
The Ohio State University Medical Center
Columbus, Ohio, United States
Alliance for Multispecialty Research
Norman, Oklahoma, United States
Lynn Institute of Norman
Norman, Oklahoma, United States
Lynn Institute - East OKC
Oklahoma City, Oklahoma, United States
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, United States
Prisma Health Endo Spc Thy Ctr
Greenville, South Carolina, United States
Holston Medical Group_Bristol
Bristol, Tennessee, United States
University Diabetes & Endocrine Consultants
Chattanooga, Tennessee, United States
MidState Endocrine Associates
Nashville, Tennessee, United States
Vanderbilt Medical Center_Nashville
Nashville, Tennessee, United States
Amarillo Medical Specialists
Amarillo, Texas, United States
Texas Diab Endo ATX N Mopac EXPR
Austin, Texas, United States
Texas Diabetes & Endocrinology
Austin, Texas, United States
Alliance Clinical Network
Dallas, Texas, United States
Thyroid Endocrinology & Diabetes PA
Dallas, Texas, United States
Velocity Clinical Res-Dallas
Dallas, Texas, United States
North Texas Endocrine Center
Dallas, Texas, United States
Research Institute Of Dallas
Dallas, Texas, United States
Precision Endo - Revival
Denton, Texas, United States
Epic Medical Research
DeSoto, Texas, United States
Frontier Medical Ctr
El Paso, Texas, United States
N. Texas Diab & Endo - Prime
Flower Mound, Texas, United States
Diabetes and Thyroid Center of Fort Worth
Fort Worth, Texas, United States
Houston Endocrinology Center
Houston, Texas, United States
The Endocrine Center
Houston, Texas, United States
Amir Ali Hassan, MD, PA
Houston, Texas, United States
RGV Endocrine Center
McAllen, Texas, United States
Tekton Research
McKinney, Texas, United States
Be Well Clinical Studies
Round Rock, Texas, United States
Texas Diabetes & Endocrinology_Round Rock
Round Rock, Texas, United States
Northeast Clinical Research of San Antonio
San Antonio, Texas, United States
Valley Diab. & Endo Comp Ctr
Weslaco, Texas, United States
Rio Clinical Trials
Ogden, Utah, United States