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Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)
Sponsor: Bristol-Myers Squibb
Summary
A Study of Izalontamab Brengitecan (BMS-986507) versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer after failure of EGFR TKI Therapy
Official title: IZABRIGHT-Lung01: A Randomized, Open-label, Phase 2/3 Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-based Chemotherapy in Patients With EGFR-mutated Non-small Cell Lung Cancer and Disease Progression on EGFR Tyrosine Kinase Inhibitor Therapy
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
500
Start Date
2025-11-05
Completion Date
2030-11-15
Last Updated
2026-10-09
Healthy Volunteers
No
Conditions
Interventions
Iza-bren
Specified dose on specified days
Carboplatin
Specified dose on specified days
Cisplatin
Specified dose on specified days
Pemetrexed
Specified dose on specified days
Locations (187)
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care building
Irvine, California, United States
University of California, Irvine (UCI) Health - UC Irvine Medical Center
Orange, California, United States
Shaw Cancer Center
Edwards, Colorado, United States
Local Institution - 0085
Gainesville, Florida, United States
Local Institution - 0142
Pembroke Pines, Florida, United States
Piedmont Healthcare
Atlanta, Georgia, United States
John B Amos Cancer Center
Columbus, Georgia, United States
Rush University Medical Center
Chicago, Illinois, United States
Dana-Farber Cancer Institute
Boston, Massachusetts, United States
Washington University School of Medicine
St Louis, Missouri, United States
Renown Regional Medical Center
Reno, Nevada, United States
Perlmutter Cancer Center at NYU Langone Hospital - Long Island
Mineola, New York, United States
NYU Langone Health
New York, New York, United States
Weill Cornell Medical College
New York, New York, United States
Rochester General Hospital Infectious Disease
Rochester, New York, United States
University Hospitals Cleveland Medical Center
Cleveland, Ohio, United States
The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive C
Columbus, Ohio, United States
Providence Cancer Institute Franz Clinic
Portland, Oregon, United States
Providence St. Vincent Medical Center
Portland, Oregon, United States
Oregon Health and Science University
Portland, Oregon, United States
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, United States
West Penn Allegheny Health
Pittsburgh, Pennsylvania, United States
Local Institution - 0268
Chattanooga, Tennessee, United States
Tennessee Oncology
Nashville, Tennessee, United States
Local Institution - 0025
Houston, Texas, United States
Local Institution - 0173
San Antonio, Texas, United States
University of Virginia Health System
Charlottesville, Virginia, United States
Virginia Commonwealth University (Vcu)
Richmond, Virginia, United States
Instituto Alexander Fleming
Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
Hospital Italiano de Buenos Aires
ABB, Buenos Aires F.D., Argentina
Hospital Privado Universitario de Córdoba
Córdoba, Argentina
Local Institution - 0280
Wilrijk, Antwerpen, Belgium
Local Institution - 0161
Auderghem, Bruxelles-Capitale, Région de, Belgium
Local Institution - 0022
Yvoir, Namur, Belgium
Local Institution - 0023
Ghent, Oost-Vlaanderen, Belgium
Local Institution - 0024
Sint-Niklaas, Oost-Vlaanderen, Belgium
Arthur J. E. Child Comprehensive Cancer Centre
Calgary, Alberta, Canada
Princess Margaret Cancer Centre
Toronto, Ontario, Canada
Local Institution - 0184
Chicoutimi, Quebec, Canada
Local Institution - 0185
Montreal, Quebec, Canada
Orlandi Oncologia
Santiago, Santiago Metropolitan, Chile
FALP
Santiago, Santiago Metropolitan, Chile
Bradfordhill
Santiago, Santiago Metropolitan, Chile
Local Institution - 0244
Beijing, Beijing Municipality, China
Local Institution - 0259
Chongqing, Chongqing Municipality, China
Fujian Cancer Hospital
Fuzhou, Fujian, China
Jiangmen Center Hospital
Jiangmen, Guangdong, China
Local Institution - 0271
Anyang, Henan, China
Local Institution - 0261
Luoyang, Henan, China
Local Institution - 0267
Jingzhou, Hubei, China
Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology
Wuhan, Hubei, China
Local Institution - 0255
Changsha, Hunan, China
Local Institution - 0256
Xuzhou, Jiangsu, China
Local Institution - 0247
Nanchang, Jiangxi, China
Local Institution - 0246
Changchun, Jilin, China
Local Institution - 0257
Shenyang, Liaoning, China
Local Institution - 0248
Jinan, Shandong, China
Local Institution - 0250
Shanghai, Shanghai Municipality, China
Local Institution - 0249
Shanghai, Shanghai Municipality, China
Shanxi Cancer Hospital
Taiyuan, Shanxi, China
Local Institution - 0252
Hangzhou, Zhejiang, China
Local Institution - 0251
Linhai, Zhejiang, China
Local Institution - 0260
Nanning, China
Local Institution - 0229
Valledupar, Cesar Department, Colombia
Local Institution - 0228
Bogotá, Cundinamarca, Colombia
Local Institution - 0227
Montería, Departamento de Córdoba, Colombia
Local Institution - 0226
Cali, Valle del Cauca Department, Colombia
Local Institution - 0014
Strasbourg, Alsace, France
Local Institution - 0017
Toulouse, Haute-Garonne, France
Local Institution - 0010
Lille, Hauts-de-France, France
Local Institution - 0018
La Tronche, Isère, France
Local Institution - 0170
Saint-Herblain, Loire-Atlantique, France
Local Institution - 0162
Bron, Rhône, France
Local Institution - 0019
Villejuif, Val-de-Marne, France
Local Institution - 0012
Marseille, France
Local Institution - 0278
Nantes, France
Local Institution - 0011
Paris, France
Local Institution - 0015
Paris, France
Local Institution - 0207
Esslingen am Neckar, Baden-Wurttemberg, Germany
Local Institution - 0238
Esslingen am Neckar, Baden-Wurttemberg, Germany
Local Institution - 0212
Stuttgart, Baden-Wurttemberg, Germany
Local Institution - 0236
Donauwörth, Bavaria, Germany
Local Institution - 0209
Oldenburg, Lower Saxony, Germany
Local Institution - 0213
Cologne, North Rhine-Westphalia, Germany
Local Institution - 0208
Chemnitz, Saxony, Germany
Local Institution - 0274
Kiel, Schleswig-Holstein, Germany
Local Institution - 0211
Berlin, Germany
Local Institution - 0215
Gauting, Germany
Local Institution - 0242
Hamburg, Germany
Local Institution - 0210
Heidelberg, Germany
Local Institution - 0239
Kassel, Germany
Local Institution - 0241
Ulm, Germany
Local Institution - 0054
Athens, Attikí, Greece
Local Institution - 0060
Chaïdári, Attikí, Greece
Local Institution - 0056
Thessaloniki, Kentrikí Makedonía, Greece
Local Institution - 0062
Thessaloniki, Thessaloníki, Greece
Local Institution - 0083
Ahmedabad, Gujarat, India
Local Institution - 0073
Ahmedabad, Gujarat, India
Local Institution - 0072
Gurugram, Haryana, India
Local Institution - 0069
Bengaluru, Karnataka, India