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OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events
Sponsor: Amgen
Summary
The primary objective is to evaluate the effect of olpasiran, compared to placebo, on the risk for coronary heart disease death (CHD death), myocardial infarction, or urgent coronary revascularization in participants at risk for a first major cardiovascular event with elevated lipoprotein(a) (Lp\[a\]).
Official title: A Double-blind, Randomized, Placebo-controlled, Multicenter Study Assessing Olpasiran Use to Prevent First Major Cardiovascular Events in Participants With Elevated Lipoprotein(a)
Key Details
Gender
All
Age Range
50 Years - 105 Years
Study Type
INTERVENTIONAL
Enrollment
11000
Start Date
2025-08-22
Completion Date
2031-10-20
Last Updated
2026-08-21
Healthy Volunteers
No
Conditions
Interventions
Olpasiran
Olpasiran will be administered via SC injection.
Placebo
Placebo will be administered via SC injection.
Locations (252)
Advanced Cardiovascular LLC
Alexander City, Alabama, United States
University of Alabama Birmingham Saint Vincents Birmingham
Birmingham, Alabama, United States
Birmingham Clinical Research
Birmingham, Alabama, United States
Alliance For Multispecialty Research - Daphne
Daphne, Alabama, United States
Eastern Shore Research Institute
Fairhope, Alabama, United States
Heart Center Research LLC
Huntsville, Alabama, United States
CB Flock Research Corporation
Mobile, Alabama, United States
Phoenix Clinical
Phoenix, Arizona, United States
Elite Clinical Studies LLC
Phoenix, Arizona, United States
Hero Clinical Research
Phoenix, Arizona, United States
HonorHealth Research Institute
Scottsdale, Arizona, United States
Eclipse Clinical Research
Tucson, Arizona, United States
Lynn Institute of the Ozarks
Little Rock, Arkansas, United States
National Heart Institute
Beverly Hills, California, United States
310 Clinical Research
Inglewood, California, United States
University of California San Diego
La Jolla, California, United States
InvivoCure
Los Angeles, California, United States
Valley Clinical Trials
Northridge, California, United States
Clinical Trials Research - Sacramento
Roseville, California, United States
Alliance Clinical Research
San Diego, California, United States
Encompass Clinical Research
Spring Valley, California, United States
Stanford Health Care
Stanford, California, United States
Manshadi Heart Institute
Stockton, California, United States
Blue Coast Cardiology
Vista, California, United States
Diablo Clinical Research
Walnut Creek, California, United States
Focus Clinical Research
West Hills, California, United States
Interventional Cardiology Medical Group
West Hills, California, United States
UCHealth Memorial Central
Colorado Springs, Colorado, United States
South Denver Cardiology Associates
Littleton, Colorado, United States
Gandelman Cardiology, PC
Greenwich, Connecticut, United States
ClinTrial Hamden
Hamden, Connecticut, United States
Chase Medical Research LLC
Waterbury, Connecticut, United States
Excel Medical Clinical Trials
Boca Raton, Florida, United States
Clearwater Cardiovascular Consultants
Clearwater, Florida, United States
Proactive Clinical Research
Fort Lauderdale, Florida, United States
Elite Cardiac Research Center LLC
Hialeah, Florida, United States
Jacksonville Center for Clinical Research
Jacksonville, Florida, United States
East Coast Institute for Research, LLC
Lake City, Florida, United States
Columbus Clinical Services LLC
Miami, Florida, United States
Kendall South Medical Center
Miami, Florida, United States
Inpatient Research Clinic, LLC
Miami Lakes, Florida, United States
Panax Clinical Research
Miami Lakes, Florida, United States
Indago Research and Health Center
Miami Lakes, Florida, United States
Eminat, LLC
Miramar, Florida, United States
Suncoast Clinical Research Inc
New Port Richey, Florida, United States
Ocala Cardiovascular Research
Ocala, Florida, United States
Ocala Research Institute, Inc
Ocala, Florida, United States
Ormond Beach Clinical Research
Ormond Beach, Florida, United States
Baptist Health Care
Pensacola, Florida, United States
Denali Health Plant City
Plant City, Florida, United States
FWD Clinical Research
Tamarac, Florida, United States
Clinical Site Partners Orlando dba Flourish Research
Winter Park, Florida, United States
Guardian Research Organization LLC
Winter Park, Florida, United States
Emory University Hospital
Atlanta, Georgia, United States
East Coast Institute for Research
Canton, Georgia, United States
Northeast Georgia Medical Center Wisteria Building
Cumming, Georgia, United States
Nsc Research
Johns Creek, Georgia, United States
Georgia Clinical Research
Lawrenceville, Georgia, United States
North Georgia Clinical Research
Woodstock, Georgia, United States
St Lukes Idaho
Meridian, Idaho, United States
Solaris Clinical Research
Meridian, Idaho, United States
Endeavor Health-Northwest Community Healthcare
Arlington Heights, Illinois, United States
Christie Clinic
Champaign, Illinois, United States
Advocate Lutheran General Hospital
Park Ridge, Illinois, United States
Alliance for Multispecialty Research LLC - Park Ridge
Park Ridge, Illinois, United States
MediSphere Medical Research Center LLC
Evansville, Indiana, United States
Parkview Research Center
Fort Wayne, Indiana, United States
Franciscan Health Indianapolis
Indianapolis, Indiana, United States
Ascension Saint Vincent Heart Center
Indianapolis, Indiana, United States
Cardiovascular Research of Northwest Indiana LLC
Munster, Indiana, United States
Reid Physician Associates
Richmond, Indiana, United States
MercyOne Iowa Heart Center
West Des Moines, Iowa, United States
Hutchinson Clinic PA
Hutchinson, Kansas, United States
University of Kansas Medical Center
Kansas City, Kansas, United States
Midwest Heart and Vascular Specialists
Overland Park, Kansas, United States
Graves Gilbert Clinic
Bowling Green, Kentucky, United States
Baptist Health Lexington
Lexington, Kentucky, United States
The Research Group of Lexington LLC
Lexington, Kentucky, United States
Heart Clinic of Hammond
Covington, Louisiana, United States
IMA Clinical Research
Monroe, Louisiana, United States
Louisiana Heart Center
Slidell, Louisiana, United States
Monroe Research LLC
West Monroe, Louisiana, United States
Ascension Saint Agnes Heart Care
Baltimore, Maryland, United States
Johns Hopkins Hospital
Baltimore, Maryland, United States
Metropolitan Cardiovascular Consultants LLC
Beltsville, Maryland, United States
Suburban Hospital
Bethesda, Maryland, United States
Flourish Research
Bowie, Maryland, United States
Johns Hopkins University
Columbia, Maryland, United States
Centennial Medical Group
Columbia, Maryland, United States
Capitol Cardiology Associates
Lanham, Maryland, United States
MedStar Health Research Institute
Olney, Maryland, United States
Brigham and Womens Hospital
Boston, Massachusetts, United States
Henry Ford Health System
Detroit, Michigan, United States
Healthy Heart Cardiology
Grand Rapids, Michigan, United States
MyMichigan Medical Center Midland - Clinical Research Department
Midland, Michigan, United States
Advanced Cardiology Associates
Rochester Hills, Michigan, United States
Revival Research Institute
Southfield, Michigan, United States
Saint Marys Medical Center
Duluth, Minnesota, United States
Health East Cancer Care
Maplewood, Minnesota, United States
University of Minnesota
Minneapolis, Minnesota, United States