Clinical Research Directory
Browse clinical research sites, groups, and studies.
The Impact Opioid Free Anesthesia on Postoperative Pain Intensity and Stress Response After Open Gynecology Surgery
Sponsor: Cantonal Hospital Zenica
Summary
This study compared impact of multimodal balancing anesthesia vs opioid free anesthesia on postoperative pain intensity and stress response after open gynecology surgery. Hypothesis was: opioid free anesthesia reduces postoperative pain intensity and stress response in terms of the value for pain in VAS (Visual Analog Scala) and for stress response in value of cortisol, prolactin and IL-6, CRP and improves postoperative patients subjective well-being and surgical outcome.
Official title: The Impact of Multimodal Balancing Anesthesia vs Opioid Free Anesthesia on Postoperative Pain Intensity and Stress Response After Open Gynecology Surgery
Key Details
Gender
FEMALE
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
70
Start Date
2025-08-22
Completion Date
2026-03-30
Last Updated
2026-11-02
Healthy Volunteers
No
Interventions
OFA group
OFA group Participants received intravenous midazolam (3 mg) and paracetamol (1 g) approximately 30 min before surgery. After standard monitoring was established, magnesium sulfate (40 mg/kg) was administered intravenously over 10 min, followed by dexamethasone (6 mg) before induction. Dexmedetomidine (0.7-1.0 μg/kg) and lidocaine (1.5 mg/kg) loading doses were initiated 10 min before induction. Anaesthesia was induced with propofol (2 mg/kg/TT) and and vecuronium bromide (0.1 mg/kg). Ketamine (0.5-1.0 mg/kg) was administered immediately before tracheal intubation, with further doses when clinically indicated. Anaesthesia was maintained with sevoflu and Dexmedetomidine (0.5-1.0 μg/kg/h) and lidocaine (1.0-1.5 mg/kg/h) infusion discontinued after last surgical sutures. TAP bloc ultrasound guided performed after intubation. Ketamine given 60 sec before incision in doses 0.5 mg/kg, and after if it is necessary according to ER and qNOX. Provided value range between 40-60 during surgery.
Locations (1)
Cantonal Hospital Zenica
Zenica, Zenica, Bosnia and Herzegovina