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Assessing the Impact of Muvalaplin on Major Cardiovascular Events in Adults With Elevated Lipoprotein(a)
Sponsor: Eli Lilly and Company
Summary
The purpose of this study is to evaluate the efficacy of muvalaplin in reducing cardiovascular risk in participants with high lipoprotein(a) who have cardiovascular disease or are at risk of a heart attack or stroke.
Official title: A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Effect of Muvalaplin on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) Who Have Had a Prior Atherosclerotic Cardiovascular Event or Are at Risk for a First Atherosclerotic Cardiovascular Event
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
10450
Start Date
2025-09-02
Completion Date
2031-03
Last Updated
2026-09-24
Healthy Volunteers
No
Interventions
Muvalaplin
Administered orally
Placebo
Administered orally
Locations (804)
Birmingham Clinical Research
Birmingham, Alabama, United States
Smiths Medical Center
Apache Junction, Arizona, United States
Phoenix Medical Trials
Gilbert, Arizona, United States
Prime Medical Group, LLC dba Gilbert Center for Family Medicine, LLC
Gilbert, Arizona, United States
Onyx Clinical Research
Phoenix, Arizona, United States
Clinical Research Institute of Arizona (CRI) - Sun City West
Sun City West, Arizona, United States
Southwest Kidney Institute - Surprise
Surprise, Arizona, United States
Pima Heart
Tucson, Arizona, United States
Eclipse Clinical Research
Tucson, Arizona, United States
National Heart Institute
Beverly Hills, California, United States
John Muir Medical Center - Concord Campus
Concord, California, United States
Neighborhood Healthcare Institute of Health
Escondido, California, United States
Ark Clinical Research - Fountain Valley
Fountain Valley, California, United States
Thrive Clinical Research Group
Glendora, California, United States
Care Access - Huntington Beach
Huntington Beach, California, United States
310 Clinical Research
Inglewood, California, United States
Scripps Whittier Diabetes Institute
La Jolla, California, United States
The Cardiovascular Center
Redding, California, United States
FOMAT Medical Research - Santa Maria
Santa Maria, California, United States
Integrated Clinical Research
Sherman Oaks, California, United States
UCLA South Bay Endocrinology
Torrance, California, United States
Lynn Institute of Denver
Aurora, Colorado, United States
University of Colorado Anschutz Medical Campus
Aurora, Colorado, United States
Legacy Clinical Trials
Colorado Springs, Colorado, United States
OptumCare Clinical Trials, LLC
Golden, Colorado, United States
Cardiology Associates of Fairfield County, P.C.
Stamford, Connecticut, United States
Chase Medical Research, LLC
Waterbury, Connecticut, United States
Excel Medical Clinical Trials
Boca Raton, Florida, United States
FWD Clinical Research
Boca Raton, Florida, United States
American Research Institute
Cutler Bay, Florida, United States
K2 Medical Research - Daytona Beach
Daytona Beach, Florida, United States
Arrow Clinical Trials
Daytona Beach, Florida, United States
Soffer Health Institute
Hollywood, Florida, United States
Jacksonville Center for Clinical Research
Jacksonville, Florida, United States
K2 MEDICAL Research THE VILLAGES
Lady Lake, Florida, United States
Clinical Research of Central Florida
Lakeland, Florida, United States
K2 Medical Research - Maitland
Maitland, Florida, United States
K2 Medical Research ORLANDO
Maitland, Florida, United States
Dade Florida Clinical Research Center
Miami, Florida, United States
Onhealth Research Center
Miami, Florida, United States
Floridian Clinical Research, LLC
Miami Lakes, Florida, United States
Advanced Research for Health Improvement, LLC
Naples, Florida, United States
Renstar Medical Research
Ocala, Florida, United States
Florida Institute For Clinical Research, LLC
Orlando, Florida, United States
Precision Clinical Research
Sunrise, Florida, United States
Care Access - Tamarac
Tamarac, Florida, United States
Care Access - Tampa
Tampa, Florida, United States
Southeastern Clinical Research Institute
Augusta, Georgia, United States
Masters of Clinical Research
Augusta, Georgia, United States
Center for Advanced Research & Education
Gainesville, Georgia, United States
NSC Research
Johns Creek, Georgia, United States
North Georgia Clinical Research
Woodstock, Georgia, United States
Elite Clinical Trials
Blackfoot, Idaho, United States
High Desert Heart & Vascular
Meridian, Idaho, United States
Elite Clinical Trials
Rexburg, Idaho, United States
Great Lakes Clinical Trials - Ravenswood
Chicago, Illinois, United States
Clinical Investigation Specialists
Gurnee, Illinois, United States
Accellacare - DuPage
Lombard, Illinois, United States
AMR Clinical
Niles, Illinois, United States
Central Illinois Diabetes and Clinical Research a Division of Prairie Education and Research Cooperative
Springfield, Illinois, United States
IU Health Bloomington
Bloomington, Indiana, United States
Indiana University Health Methodist Hospital
Indianapolis, Indiana, United States
Franciscan Physician Network - Indiana Heart Physicians
Indianapolis, Indiana, United States
Iowa Diabetes and Endocrinology Research Center
West Des Moines, Iowa, United States
Cotton O'Neil Clinical Research Center
Topeka, Kansas, United States
Saint Elizabeth Healthcare - Saint Elizabeth Covington Hospital
Covington, Kentucky, United States
Tulane University School of Medicine
New Orleans, Louisiana, United States
MaineHealth Cardiology
Scarborough, Maine, United States
Ascension Saint Agnes Heart Care
Baltimore, Maryland, United States
Metropolitan Cardiovascular Consultants
Beltsville, Maryland, United States
Flourish Research - Bowie
Bowie, Maryland, United States
Johns Hopkins University
Columbia, Maryland, United States
Centennial Medical Group
Columbia, Maryland, United States
Anderson Medical Research
Ft. Washington, Maryland, United States
Brigham and Women's Hospital Diabetes Program
Boston, Massachusetts, United States
Lucida Clinical Trials
New Bedford, Massachusetts, United States
Care Access - Quincy
Quincy, Massachusetts, United States
Revival Research Institute, LLC
Dearborn, Michigan, United States
Arcturus Healthcare , PLC, Troy Internal Medicine Research Division
Troy, Michigan, United States
Boeson Research MSO
Missoula, Montana, United States
Desert Clinical Research, LLC
Henderson, Nevada, United States
Clinical Research of South Nevada
Las Vegas, Nevada, United States
Vector Clinical Trials
Las Vegas, Nevada, United States
Renascor Clinical Research
Reno, Nevada, United States
Vector Clinical Trials
Sparks, Nevada, United States
Clinical Research of Philadelphia
Pennington, New Jersey, United States
Cardio Metabolic Institute
Somerset, New Jersey, United States
IMA Clinical Research
Albuquerque, New Mexico, United States
Southwest Cardiovascular Center
Albuquerque, New Mexico, United States
Capital Cardiology Associates
Albany, New York, United States
Velocity Clinical Research, Syracuse
East Syracuse, New York, United States
NYC Research
New York, New York, United States
Weill Cornell Medical College
New York, New York, United States
Rochester Clinical Research, LLC
Rochester, New York, United States
SUNY Upstate Medical University
Syracuse, New York, United States
Southgate Medical Group
West Seneca, New York, United States
Care Access - Fayetteville
Fayetteville, North Carolina, United States
Medication Management
Greensboro, North Carolina, United States
Monroe Biomedical Research
Monroe, North Carolina, United States
Accellacare - Raleigh
Raleigh, North Carolina, United States