Tundra Space

Tundra Space

Clinical Research Directory

Browse clinical research sites, groups, and studies.

Back to Studies
RECRUITING
NCT07162415
NA

Ganglion Resection Effectiveness Trial

Sponsor: Tampere University Hospital

View on ClinicalTrials.gov

Summary

The goal of this clinical trial is to learn if surgery helps with wrist ganglions in adults. The main question it aims to answer is: * Does surgery result in better patient-reported outcomes and satisfaction over a 6-months follow-up period? Researchers will compare surgery to conservative treatment (self-administered exercises and use of the hand as tolerated) to see if surgery provides superior outcomes. Participants will: * Be randomly assigned to receive either surgery or conservative treatment * Complete questionnaires about wrist pain, function, quality of life, satisfaction, and recovery at 3, 6, and 12 months

Official title: GangLion Resection Effectiveness Trial (GangLion): a Multicentre, Randomized, Superiority Trial

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

220

Start Date

2026-01-13

Completion Date

2035-12

Last Updated

2026-10-22

Healthy Volunteers

No

Interventions

PROCEDURE

Open resection

A transverse or longitudinal incision is done depending on surgeon's preference. The ganglion and its pedicle are traced up to its origin. The pedicle is resected tangentially, usually, from the SL ligament for dorsal ganglions and depending on the site for volar ganglion. Wrist capsule is not closed.

PROCEDURE

Arthroscopic resection

Portals are selected by surgeon's preference. The pedicle of the ganglion is located and resected with a shaver. It is not necessary to remove all the ganglion walls. The portal incisions do not need to be sutured.

OTHER

Conservative treatment

Participant will be informed about the natural course of wrist ganglions. The conservative treatment may include needle aspiration of the ganglion, but it is not performed routinely. If a participant requests aspiration, the decision to perform it is left to the clinical discretion of the treating physician. Participants are informed that wrist loading in extension may exacerbate the pain, and that the pain is not a sign of further injury to wrist joint. They may avoid heavy use if they have too much pain, but they are advised to use hand as tolerated. Participants may use NSAIDs and acetaminophen for pain management as needed; however, the protocol does not specify a required course or dosage. Every participant is given simple self-implemented exercise therapy instructions; the exercises are to be performed three times a week until symptoms are relieved.

Locations (6)

Helsinki University Hospital

Helsinki, Finland

Hospital Nova of Central Finland

Jyväskylä, Finland

Päijät-Häme Central Hospital

Lahti, Finland

Oulu University Hospital

Oulu, Finland

Tampere University Hospital

Tampere, Finland

National University Hospital

Singapore, Singapore