Clinical Research Directory
Browse clinical research sites, groups, and studies.
A Study to Evaluate the Efficacy and Safety of Intravenous (IV) Prasinezumab in Participants With Early-Stage Parkinson's Disease
Sponsor: Hoffmann-La Roche
Summary
The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics (PK) of prasinezumab compared with placebo in participants with early-stage Parkinson's disease (PD) on stable symptomatic monotherapy with levodopa.
Official title: A Phase III, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of Intravenous Prasinezumab in Participants With Early-Stage Parkinson's Disease
Key Details
Gender
All
Age Range
50 Years - 85 Years
Study Type
INTERVENTIONAL
Enrollment
900
Start Date
2025-11-24
Completion Date
2031-06-30
Last Updated
2026-10-06
Healthy Volunteers
No
Conditions
Interventions
Prasinezumab
Participants will receive Prasinezumab as an IV Infusion as per the schedule mentioned in the protocol.
Placebo
Participants will receive Placebo as an IV Infusion per the schedule mentioned in the protocol
Locations (192)
University of Alabama at Birmingham
Birmingham, Alabama, United States
Barrow Neurological Institute
Phoenix, Arizona, United States
Neurology Center of North Orange County
Fullerton, California, United States
UC San Diego
La Jolla, California, United States
Keck School of Medicine of USC
Los Angeles, California, United States
UCLA Neurology Outpatient Clinic
Los Angeles, California, United States
Parkinson?s Research Centers of America ? Palo Alto
Palo Alto, California, United States
Profound Research LLC at The Neurology Center of Southern California
Pasadena, California, United States
UCSF Weill Institute for Neurosciences
San Francisco, California, United States
Stanford Neuroscience Health Center (SNHC)
Stanford, California, United States
Rocky Mountain Movement Disorders
Englewood, Colorado, United States
Institute for Neurodegenerative Disorders
New Haven, Connecticut, United States
Georgetown University
Washington D.C., District of Columbia, United States
JEM Research LLC
Atlantis, Florida, United States
Parkinson's Disease and Movement Disorders Center of Boca Raton
Boca Raton, Florida, United States
K2 - Villages
Lady Lake, Florida, United States
K2 Medical Research-Maitland
Maitland, Florida, United States
Baptist Hospital of Miami
Miami, Florida, United States
Charter Research - Winter Park/Orlando
Orlando, Florida, United States
Advent Health Orlando
Orlando, Florida, United States
USF Parkinsons Disease and Movement Disorders Center
Tampa, Florida, United States
Grady Memorial Hospital
Atlanta, Georgia, United States
Hawaii Pacific Neuroscience
Honolulu, Hawaii, United States
Northwestern University Feinberg School Of Medicine
Chicago, Illinois, United States
University of Kansas Medical Center
Kansas City, Kansas, United States
Massachusetts General Hospital
Boston, Massachusetts, United States
Quest Research Institute
Farmington Hills, Michigan, United States
Washington Uni School of Medicine
St Louis, Missouri, United States
Cleveland Clinic Lou Ruvo
Las Vegas, Nevada, United States
Renown Health
Reno, Nevada, United States
Hackensack University Medical Center;Department of Neurology, Neuroscience Institute
Paramus, New Jersey, United States
University of New Mexico
Albuquerque, New Mexico, United States
Dent Neurological Institute
Amherst, New York, United States
Parkinson's Research Centers of America - Long Island
Commack, New York, United States
Weill Cornell Medical College
New York, New York, United States
Columbia University Medical Center
New York, New York, United States
Asheville Neurology
Asheville, North Carolina, United States
Duke University Medical Center
Durham, North Carolina, United States
NeuroCare Center
Canton, Ohio, United States
Cleveland Clinic
Cleveland, Ohio, United States
The Movement Disorder Clinic of Oklahoma
Tulsa, Oklahoma, United States
Oregon Health and Science University
Portland, Oregon, United States
University Pennsylvania Hospital
Philadelphia, Pennsylvania, United States
Allegheny General Hospital
Pittsburgh, Pennsylvania, United States
Avera Medical Group
Sioux Falls, South Dakota, United States
Veracity Neuroscience
Memphis, Tennessee, United States
Vanderbilt University Medical Center
Nashville, Tennessee, United States
Texas Neurology PA
Dallas, Texas, United States
Central Texas Neurology Consultants
Round Rock, Texas, United States
University of Vermont Medical Center
Burlington, Vermont, United States
University of Virginia Health System
Charlottesville, Virginia, United States
VCU Health North Hospital
Richmond, Virginia, United States
West Virginia University
Morgantown, West Virginia, United States
Southern Neurology
Kogarah, New South Wales, Australia
Westmead Hospital
Westmead, New South Wales, Australia
Princess Alexandra Hospital
Woolloongabba, Queensland, Australia
Monash Health
Clayton, Victoria, Australia
Royal Melbourne Hospital
Parkville, Victoria, Australia
The Alfred Hospital
Prahan, Victoria, Australia
Perron Institute for Neurological and Translational Science
Nedlands, Western Australia, Australia
Medizinische Universität Graz
Graz, Austria
Uniklinik fuer Neurologie, Medizinische Universitaet Innsbruck
Innsbruck, Austria
Kepler Universitätsklinikum GmbH - Neuromed Campus
Linz, Austria
Medizinische Universität Wien
Vienna, Austria
Klinik Ottakring
Vienna, Austria
Santa Casa de Misericordia de Salvador
Salvador, Estado de Bahia, Brazil
L2 Ip Instituto de Pesquisas Clinicas Ltda ME
Brasília, Federal District, Brazil
Hospital das Clinicas - UFMG
Belo Horizonte, Minas Gerais, Brazil
Instituto de Neurologia de Curitiba
Curitiba, Paraná, Brazil
Núcleo de Pesquisa do Rio Grande do Sul
Porto Alegre, Rio Grande do Sul, Brazil
Faculdade de Medicina de Ribeirão Preto - Universidade de Sao Paulo
Ribeirão Preto, São Paulo, Brazil
Faculdade de Medicina de Sao Jose do Rio Preto - FAMERP*X*
São José do Rio Preto, São Paulo, Brazil
Centro de Pesquisas Clinicas
São Paulo, São Paulo, Brazil
University Health Network
Toronto, Ontario, Canada
CHUM
Montreal, Quebec, Canada
Montreal Neurological Institute and Hospital
Montreal, Quebec, Canada
Beijing Friendship Hospital Affiliated of Capital University of Medical Science
Beijing, China
Xuanwu Hospital, Capital Medical University
Beijing, China
Beijing Tian Tan Hospital,Capital Medical University
Beijing, China
Beijing Hospital of Ministry of Health
Beijing, China
The First Hospital of Jilin University
Changchun, China
West China Hospital of Sichuan University
Chengdu, China
The First Affiliated Hospital, Chongqing Medical University
Chongqing, China
Fujian Medical University Union Hospital
Fuzhou, China
The First Affiliated Hospital of Sun Yat-sen University
Guangzhou, China
Guangdong Provincial People's Hospital
Guangzhou, China
The First Affiliated Hospital of Guangzhou Medical University
Guangzhou, China
The Second Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou, China
Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University
Hangzhou, China
Nanjing Brain Hospital
Nanjing, China
Ruijin Hospital Shanghai Jiaotong University School of Medicine
Shanghai, China
Huashan Hospital, Fudan University
Shanghai, China
Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Shanghai, China
The Second Affiliated Hospital of Soochow University
Suzhou, China
Tianjin Medical University General Hospital
Tianjin, China
First Affiliated Hospital of Medical College of Xi'an Jiaotong University
Xi'an, China
The Affiliated Hospital of Xuzhou Medical University
Xuzhou, China
Aarhus Universitetshospital Skejby
Aarhus N, Denmark
Regionshospitalet Gødstrup;Neurologisk Afdeling
Herning, Denmark
Bispebjerg Hospital;Neurologisk Afdeling
København NV, Denmark