Clinical Research Directory
Browse clinical research sites, groups, and studies.
Cilostazol for Prevention of Recurrent Stroke Trial
Sponsor: Stanford University
Summary
The goal of this clinical study is to learn if adding a medicine called cilostazol to usual treatment can help prevent another stroke, a heart attack, or death in patients who had a stroke caused by a blocked blood vessel, or a "mini-stroke" (also called a TIA), in the past 6 months. To determine if cilostazol is safe and effective at lowering the chance of strokes, heart attacks and deaths, the study will compare cilostazol to a placebo, a pill that looks the same as cilostazol but has no medicine in it. Participants will: * Be assigned by chance to take either cilostazol or a placebo, along with their usual medicine. * Not know which one they are taking, and neither will the study team, which keeps the results fair. * Be followed for up to 5 years to see if they have a stroke, heart attack, or major bleeding.
Key Details
Gender
All
Age Range
40 Years - Any
Study Type
INTERVENTIONAL
Enrollment
2000
Start Date
2026-10
Completion Date
2031-07
Last Updated
2026-10-26
Healthy Volunteers
No
Conditions
Interventions
Cilostazol 100 mg Tablets
The standard dosing regimen is an initial 2-week period during which participants take one tablet of cilostazol (100 mg) orally once daily followed by a maintenance phase in which they take one tablet twice daily. For participants who are on certain interacting drugs or who experience adverse reactions on the standard dosing regimen, the dose is reduced to half a tablet twice daily.
Placebo
The standard dosing regimen is an initial 2-week period during which participants take one placebo tablet, which matches cilostazol 100 mg tablets, orally once daily followed by a maintenance phase in which they take one tablet twice daily. For participants who are on certain interacting drugs or who experience adverse reactions on the standard dosing regimen, the dose is reduced to half a tablet twice daily.
Locations (52)
University of Alabama Hospital - Birmingham
Birmingham, Alabama, United States
University of South Alabama - University Hospital
Mobile, Alabama, United States
Chandler Regional Medical Center
Chandler, Arizona, United States
Kaiser Permanente Fontana Medical Center
Fontana, California, United States
UCSD Health La Jolla
La Jolla, California, United States
Kaiser Permanente Los Angeles Medical Center
Los Angeles, California, United States
Cedars-Sinai Medical Center
Los Angeles, California, United States
Casa Colina Hospital
Pomona, California, United States
Stanford University
Stanford, California, United States
Intermountain Health - St. Mary's Medical Center
Grand Junction, Colorado, United States
Yale New Haven Hospital
New Haven, Connecticut, United States
UF Health Jacksonville
Jacksonville, Florida, United States
Emory University Hospital
Atlanta, Georgia, United States
Grady Memorial Hospital
Atlanta, Georgia, United States
Memorial Hospital of Carbondale
Carbondale, Illinois, United States
University of Iowa Medical Center
Iowa City, Iowa, United States
University of Kansas Hospital
Kansas City, Kansas, United States
University of Maryland Medical Center
Baltimore, Maryland, United States
Boston Medical Center
Boston, Massachusetts, United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States
University of Michigan - University Hospital
Ann Arbor, Michigan, United States
Mclaren Flint
Flint, Michigan, United States
Abbott Northwestern Hospital
Minneapolis, Minnesota, United States
M Health Fairview University of Minnesota Medical Center
Minneapolis, Minnesota, United States
Regions Hospital
Saint Paul, Minnesota, United States
Barnes-Jewish Hospital
St Louis, Missouri, United States
SSM Health St. Louis University Hospital
St Louis, Missouri, United States
Kings County Hospital Center
Brooklyn, New York, United States
NYU Langone Hospital - Brooklyn
Brooklyn, New York, United States
NYP Weill Cornell Medical Center
New York, New York, United States
Duke University Hospital
Durham, North Carolina, United States
New Hanover Regional Medical Center
Wilmington, North Carolina, United States
Wake Forest Baptist Medical Center
Winston-Salem, North Carolina, United States
Cleveland Clinic Akron General
Akron, Ohio, United States
University of Cinncinati
Cincinnati, Ohio, United States
Oklahoma University Medical Center
Oklahoma City, Oklahoma, United States
Providence St. Vincent Medical Center
Portland, Oregon, United States
Oregon Health & Science University Hospital
Portland, Oregon, United States
UPMC Hamot
Erie, Pennsylvania, United States
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, United States
Temple University Hospital
Philadelphia, Pennsylvania, United States
Medical University of South Carolina University Hospital
Charleston, South Carolina, United States
Prisma Health Richland Hospital
Columbia, South Carolina, United States
Methodist University Hospital
Memphis, Tennessee, United States
University of Texas Health Science Center San Antonio
San Antonio, Texas, United States
Intermountain Medical Center
Murray, Utah, United States
University of Utah Healthcare
Salt Lake City, Utah, United States
UVA Medical Center
Charlottesville, Virginia, United States
Bon Secours St. Mary's Hospital
Richmond, Virginia, United States
Harborview Medical Center
Seattle, Washington, United States
J.W. Ruby Memorial Hospital
Morgantown, West Virginia, United States
University of Wisconsin - University Hospital
Madison, Wisconsin, United States