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Study to Evaluate INCB123667 Versus Investigator's Choice of Chemotherapy in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression
Sponsor: Incyte Corporation
Summary
The purpose of this study is to evaluate INCB123667 versus investigator's choice of chemotherapy in participants with platinum-resistant ovarian cancer with cyclin E1 overexpression.
Official title: A Phase 3, Randomized, Open-Label Study of INCB123667 Versus Investigator's Choice of Chemotherapy in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
466
Start Date
2025-12-09
Completion Date
2029-05-14
Last Updated
2026-10-15
Healthy Volunteers
No
Conditions
Interventions
INCB123667
Oral; tablet
Investigator's choice of chemotherapy
The investigator will select the chemotherapy in accordance with the protocol-defined requirements. The possible choices as defined by the protocol:
Locations (198)
Alaska Womens Cancer Care Akwcc
Anchorage, Alaska, United States
University of Arizona Cancer Center
Tucson, Arizona, United States
City of Hope Medical Center
Duarte, California, United States
Providence Medical Foundation
Fullerton, California, United States
University of California, San Diego-Moores Cancer Center
La Jolla, California, United States
Valkyrie Clinical Trials
Los Angeles, California, United States
Uci Health Chao Family Comprehensive Cancer Center
Orange, California, United States
Ventura County Hematology Oncology Specialists-Oxnard
Oxnard, California, United States
University of Colorado Cancer Center
Aurora, Colorado, United States
Mount Sinai Medical Center Comprehensive Cancer Center
Miami Beach, Florida, United States
Brcr Global
Miramar, Florida, United States
Sarasota Memorial Health Care System
Sarasota, Florida, United States
Winship Cancer Institute At Emory University
Atlanta, Georgia, United States
Georgia Cancer Center
Augusta, Georgia, United States
The University of Chicago Medicine
Chicago, Illinois, United States
Carle Cancer Center
Effingham, Illinois, United States
Northshore University Health System-Evanston Hospital
Evanston, Illinois, United States
City of Hope - Chicago Cancer Center
Zion, Illinois, United States
St Elizabeth Healthcare
Edgewood, Kentucky, United States
Women'S Cancer Care
Covington, Louisiana, United States
Trials365, Llc
Shreveport, Louisiana, United States
Maine Center For Cancer Medicine
Scarborough, Maine, United States
Holy Cross Hospital
Silver Spring, Maryland, United States
Greater Baltimore Medical Center
Towson, Maryland, United States
Henry Ford Cancer - Detroit
Detroit, Michigan, United States
Mercy Hospital St. Louis - David C. Pratt Cancer Center
St Louis, Missouri, United States
Billings Clinic
Billings, Montana, United States
Women'S Cancer Center of Nevada
Las Vegas, Nevada, United States
Center of Hope
Reno, Nevada, United States
Maimonides Medical Center
Short Hills, New Jersey, United States
Unm Comprehensive Cancer Center
Albuquerque, New Mexico, United States
Levine Cancer Center
Charlotte, North Carolina, United States
Novant Presbyterian Hospital
Charlotte, North Carolina, United States
East Carolina University
Greenville, North Carolina, United States
Novant Health Oncology Specialists
Winston-Salem, North Carolina, United States
Atrium Health Wake Forest Baptist
Winston-Salem, North Carolina, United States
Cleveland Clinic Foundation
Cleveland, Ohio, United States
Ohio Health Research Institute
Columbus, Ohio, United States
Miami Valley Hospital South
Dayton, Ohio, United States
Promedica Flower Hospital
Sylvania, Ohio, United States
Oncology Associates of Oregon, P.C.
Eugene, Oregon, United States
Providence Cancer Institute Franz Clinic
Portland, Oregon, United States
Penn State Milton S. Hershey Medical Center
Hershey, Pennsylvania, United States
University of Pittsburgh Cancer Institute Cancer Services
Pittsburgh, Pennsylvania, United States
Allegheny Health Network- West Penn Hospital
Pittsburgh, Pennsylvania, United States
Lankenau Medical Center
Wynnewood, Pennsylvania, United States
Wellspan Gynecologic Oncology
York, Pennsylvania, United States
Sanford Cancer Center-Sioux Falls
Sioux Falls, South Dakota, United States
Erlanger Health, Inc.
Chattanooga, Tennessee, United States
Texas Oncology-Abilene
Abilene, Texas, United States
Texas Oncology Cancer Center
Austin, Texas, United States
Jps Health Network
Fort Worth, Texas, United States
The University of Texas Health Science Center Houston
Houston, Texas, United States
The University of Texas-Md Anderson Cancer Center
Houston, Texas, United States
Texas Oncology, P.A., San Antonio Medical Center - Uso
San Antonio, Texas, United States
Texas Oncology Cancer Center
Sugar Land, Texas, United States
Texas Oncology (Txo) Northeast Texas (Tyler)
Tyler, Texas, United States
University of Virginia Health System
Charlottesville, Virginia, United States
Inova Schar Cancer Institute
Fairfax, Virginia, United States
Fred Hutchinson Cancer Center
Seattle, Washington, United States
Providence Sacred Heart Medical Center and Children'S Hospital
Spokane, Washington, United States
West Virginia University
Morgantown, West Virginia, United States
Prohealth Care
Waukesha, Wisconsin, United States
Chris O'Brien Lifehouse Hospital
Camperdown, New South Wales, Australia
Concord Repatriation General Hospital
Concors, New South Wales, Australia
The Wollongong Hospital
Wollongong, New South Wales, Australia
Mater Hospital Brisbane
South Brisbane, Queensland, Australia
Icon Cancer Care - Townsville
Townsville, Queensland, Australia
Eastern Health-Box Hill Hospital
Box Hill, Victoria, Australia
Hopital Universitaire de Bruxelles (Hub) - Institut Jules Bordet
Brussels, Belgium
Cliniques Universitaires St Luc Ucl
Brussels, Belgium
Az Maria Middelares Gent
Ghent, Belgium
UZ GENT
Ghent, Belgium
Az Groeninge
Kortrijk, Belgium
Universitair Ziekenhuis Leuven
Leuven, Belgium
Tom Baker Cancer Center-Alberta Health Services (Ahs) - University of Calgary
Calgary, Alberta, Canada
Cross Cancer Insititute
Edmonton, Alberta, Canada
London Health Sciences Centre
London, Ontario, Canada
University Health Network (Uhn) - Princess Margaret Cancer Centre
Toronto, Ontario, Canada
Sir Mortimer B. Davis - Jewish General Hospital
Montreal, Quebec, Canada
Cedars Cancer Centre - McGill University Health Centre (Muhc) - Glen Site
Montreal, Quebec, Canada
Ch Davignon - Hopital Henri Duffaut
Avignon, France
Clinique Tivoli
Bordeaux, France
Clinique Pole Sante Leonard de Vinci
Chambray-lès-Tours, France
Centre Hospitalier Departemental de Vendee, Hopital de La-Roche-Sur-Yon Les Oudairies
La Roche-sur-Yon, France
Centre Hospitalier Universitaire de Grenoble- Hopital Albert Michallon
La Tronche, France
Hopital Prive Jean Mermoz
Lyon, France
Institut Paoli Calmettes
Marseille, France
Centre Antoine Laccassagne
Nice, France
Hospital Tenon
Paris, France
Centre Eugene Marquis
Rennes, France
Hopital de Hautepierre
Strasbourg, France
Institut Gustave Roussy-Gustave Roussy Cancer Center -Ditep
Villejuif, France
Charite Campus Virchow
Berlin, Germany
Universitaetsklinikum Bonn
Bonn, Germany
Universitaetsklinikum Dresden
Dresden, Germany
Kliniken Essen-Mitte
Essen, Germany
Klinikum Kassel Gmbh
Kassel, Germany
Universitatsklinikum Schleswig Holstein
Kiel, Germany
Universitätsmedizin Mannheim
Mannheim, Germany