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A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer
Sponsor: Bristol-Myers Squibb
Summary
The purpose of this study is to evaluate the safety and efficacy of pumitamig in combination with chemotherapy versus bevacizumab in combination with chemotherapy in participants with previously untreated, unresectable, or metastatic colorectal cancer
Official title: ROSETTA CRC-203: A Blinded, Randomized Phase 2/3 Study of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
990
Start Date
2025-12-31
Completion Date
2034-03-11
Last Updated
2026-10-23
Healthy Volunteers
No
Interventions
Pumitamig
Specified dose on specified days
FOLFOX
Specified dose on specified days
FOLFIRI
Specified dose on specified days
Bevacizumab
Specified dose on specified days
CAPOX
Specified dose on specified days
Locations (286)
Local Institution - 0428
Tucson, Arizona, United States
Highlands Oncology Group
Springdale, Arkansas, United States
USC/Norris Comprehensive Cancer Center
Los Angeles, California, United States
Local Institution - 0330
Los Angeles, California, United States
University of California, Irvine (UCI) Health - UC Irvine Medical Center
Orange, California, United States
California Pacific Medical Center - Pacific Campus
San Francisco, California, United States
Florida Cancer Specialists - East
Cape Coral, Florida, United States
Florida Cancer Specialists - North
St. Petersburg, Florida, United States
Moffitt Cancer Center
Tampa, Florida, United States
Local Institution - 0326
Atlanta, Georgia, United States
Northside Hospital
Atlanta, Georgia, United States
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital
Marietta, Georgia, United States
University of Chicago Medical Center
Chicago, Illinois, United States
Local Institution - 0638
Fort Wayne, Indiana, United States
University of Iowa
Iowa City, Iowa, United States
Local Institution - 0262
Baltimore, Maryland, United States
Maryland Oncology Hematology - Silver Spring
Silver Spring, Maryland, United States
Local Institution - 0471
Boston, Massachusetts, United States
Local Institution - 0430
Ann Arbor, Michigan, United States
Local Institution - 0254
Grand Rapids, Michigan, United States
Minnesota Oncology
Maple Grove, Minnesota, United States
Local Institution - 0318
Kansas City, Missouri, United States
Washington University School OF Medicine-Siteman Cancer Center
St Louis, Missouri, United States
University Of Nebraska Medical Center
Omaha, Nebraska, United States
Northwell Health/ RJ Zuckerberg Cancer Center
Lake Success, New York, United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone
Mineola, New York, United States
New York Cancer and Blood Specialists
Shirley, New York, United States
Local Institution - 0290
Charlotte, North Carolina, United States
Sanford Fargo Medical Center
Fargo, North Dakota, United States
The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer Center
Columbus, Ohio, United States
Lehigh Valley Health Network
Allentown, Pennsylvania, United States
Local Institution - 0604
Pittsburgh, Pennsylvania, United States
Sanford Cancer Center
Sioux Falls, South Dakota, United States
Local Institution - 0333
Nashville, Tennessee, United States
SCRI Oncology Partners
Nashville, Tennessee, United States
Texas Oncology Dallas Fort Worth West (DFWW) - Arlington Cancer Center North
Arlington, Texas, United States
Texas Oncology, PA
Austin, Texas, United States
Baylor College of Medicine Medical Center
Houston, Texas, United States
Texas Oncology - San Antonio
San Antonio, Texas, United States
Local Institution - 0426
Salt Lake City, Utah, United States
Local Institution - 0278
Fairfax, Virginia, United States
Virginia Oncology Associates
Norfolk, Virginia, United States
Local Institution - 0491
Edmonds, Washington, United States
Local Institution - 0253
Seattle, Washington, United States
Local Institution - 0629
Spokane, Washington, United States
Northwest Cancer Specialists, P.C.
Vancouver, Washington, United States
Hospital Británico de Buenos Aires
CABA, Buenos Aires, Argentina
Centro Médico Fleischer
Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
Instituto Alexander Fleming
Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
Hospital Italiano de Buenos Aires
ABB, Buenos Aires F.D., Argentina
Clínica Mayo de Urgencias Médicas Cruz Blanca S.R.L
San Miguel de Tucumán, Tucumán Province, Argentina
Centro de Educación Médica e Investigaciones clínicas "Dr. Norberto Quirno" (CEMIC)
Buenos Aires, Argentina
Sanatorio Allende - Nueva Córdoba
Córdoba, Argentina
Chris O'Brien Lifehouse
Camperdown, New South Wales, Australia
Liverpool Hospital
Liverpool, New South Wales, Australia
GenesisCare St Leonards
St Leonards, New South Wales, Australia
Westmead Hospital
Westmead, New South Wales, Australia
Sunshine Coast University Hospital
Birtinya, Queensland, Australia
Royal Brisbane and Women's Hospital
Brisbane, Queensland, Australia
Gallipoli Medical Research Ltd
Brisbane, Queensland, Australia
Flinders Medical Centre
Adelaide, South Australia, Australia
Lyell McEwin Hospital
Elizabeth Vale, South Australia, Australia
Grampians Health
Ballarat Central, Victoria, Australia
Northern Hospital
Epping, Victoria, Australia
Cabrini Hospital - Malvern
Malvern, Victoria, Australia
Goulburn Valley Health
Shepparton, Victoria, Australia
Western Health-Sunshine & Footscray Hospitals
St Albans, Victoria, Australia
St. John of God Murdoch Hospital
Murdoch, Western Australia, Australia
Local Institution - 0164
Feldkirch, Austria
Krankenhaus Der Barmherzigen Schwestern Linz
Linz, Austria
Universitaetsklinik Salzburg
Salzburg, Austria
Universitätsklinikum St. Pölten
Sankt Pölten, Austria
Medizinische Universitaet Wien/AKH
Vienna, Austria
Imelda General Hospital
Bonheiden, Antwerpen, Belgium
Antwerp University Hospital
Edegem, Antwerpen, Belgium
Cliniques universitaires Saint-Luc
Brussels, Bruxelles-Capitale, Région de, Belgium
Local Institution - 0620
Charleroi, Hainaut, Belgium
UZ Leuven
Leuven, Vlaams-Brabant, Belgium
AZ Delta vzw
Roeselare, West-Vlaanderen, Belgium
Local Institution - 0118
Brussels, Belgium
Centro Integrado de Oncologia de Curitiba
Curitiba, Paraná, Brazil
Liga Norte Riograndense Contra o Câncer
Natal, Rio Grande do Norte, Brazil
Local Institution - 0375
Porto Alegre, Rio Grande do Sul, Brazil
Hospital São Lucas da PUCRS
Porto Alegre, Rio Grande do Sul, Brazil
Instituto de Oncologia Saint Gallen
Santa Cruz do Sul, Rio Grande do Sul, Brazil
Fundação Pio XII - Hospital de Câncer de Barretos
Barretos, São Paulo, Brazil
Faculdade de Medicina de Sao Jose do Rio Preto
São José do Rio Preto, Brazil
Local Institution - 0268
São Paulo, Brazil
Local Institution - 0341
São Paulo, Brazil
Local Institution - 0550
Calgary, Alberta, Canada
Local Institution - 0260
Halifax, Nova Scotia, Canada
Local Institution - 0255
Ottawa, Ontario, Canada
Local Institution - 0424
Toronto, Ontario, Canada
Local Institution - 0421
Toronto, Ontario, Canada
Centre Hospitalier de l'Université de Montréal
Montreal, Quebec, Canada
Jewish General Hospital
Montreal, Quebec, Canada
Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Universitaire de Sherbrooke (CIUS
Sherbrooke, Quebec, Canada
Bradfordhill
Recoleta, Santiago Metropolitan, Chile
Fundacion Oncologia Arturo Lopez Perez
Santiago, Santiago Metropolitan, Chile
Local Institution - 0175
Santiago, Santiago Metropolitan, Chile