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A Study of Pasritamig With Docetaxel Versus Docetaxel in Participants With Metastatic Castration-Resistant Prostate Cancer
Sponsor: Janssen Research & Development, LLC
Summary
The purpose of this study is to find out whether treatment with pasritamig and docetaxel prolongs radiographic progression free survival (rPFS) (the length of time from start of treatment until disease worsens as determined by scans or death due to any cause) when compared to treatment with docetaxel in participants with metastatic castrate-resistant prostate cancer (mCRPC; a cancer of prostate, a male reproductive gland found below the bladder, that grows despite low levels of male hormones).
Official title: A Phase 3 Randomized, Open-label Study of Pasritamig (JNJ-78278343), a T-cell-engaging Agent Targeting Human Kallikrein 2, With Docetaxel Versus Docetaxel for Metastatic Castration-resistant Prostate Cancer
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
800
Start Date
2025-12-19
Completion Date
2030-06-07
Last Updated
2026-11-03
Healthy Volunteers
No
Interventions
Pasritamig
Pasritamig will be administered.
Docetaxel
Docetaxel will be administered.
Prednisone/Prednisolone
Prednisone/Prednisolone will be administered.
Locations (165)
Arizona Clinical Trials
Chandler, Arizona, United States
Arkansas Urology
Little Rock, Arkansas, United States
Highlands Oncology Group
Springdale, Arkansas, United States
MemorialCare Orange Coast Medical Center
Fountain Valley, California, United States
University Of California San Diego
La Jolla, California, United States
Cancer and Blood Specialty Clinic
Los Alamitos, California, United States
USC Norris Comprehensive Cancer Center
Los Angeles, California, United States
Valkyrie Clinical Trials
Los Angeles, California, United States
Ronald Reagan UCLA Medical Center
Los Angeles, California, United States
Kaiser Permanente Southern California
Riverside, California, United States
Sharp Center for Research
San Diego, California, United States
Providence Saint John s Health Center
Santa Monica, California, United States
Rocky Mountain Cancer Centers
Aurora, Colorado, United States
AdventHealth Porter Oncology Research
Denver, Colorado, United States
Vail Health Shaw Cancer Center
Edwards, Colorado, United States
Grand Valley Oncology
Grand Junction, Colorado, United States
Colorado Clinical Research
Lakewood, Colorado, United States
AdventHealth Orlando
Orlando, Florida, United States
Memorial Cancer Institute
Pembroke Pines, Florida, United States
Florida Cancer Specialists
Sarasota, Florida, United States
Winship Cancer Institute Emory University
Atlanta, Georgia, United States
Duly Health and Care
Lisle, Illinois, United States
Cancer Center of Kansas Heritage Plaza Medical Building
Wichita, Kansas, United States
St Elizabeth Healthcare
Edgewood, Kentucky, United States
Norton Cancer Institute
Louisville, Kentucky, United States
East Jefferson General Hospital
Metairie, Louisiana, United States
University of Maryland
Baltimore, Maryland, United States
Johns Hopkins Hospital
Baltimore, Maryland, United States
Johns Hopkins Medical Institutions
Baltimore, Maryland, United States
Center for Cancer and Blood Disorders
Bethesda, Maryland, United States
Chesapeake Urology Research Associates
Towson, Maryland, United States
Massachusetts General
Boston, Massachusetts, United States
Profound Research LLC at Cancer and Leukemia Center
Sterling Heights, Michigan, United States
HealthPartners Frauenshuh Cancer Center CRC West
Saint Louis Park, Minnesota, United States
HealthPartners Cancer Center at Regions Hospital CRC East
Saint Paul, Minnesota, United States
University of Mississippi Medical Center
Jackson, Mississippi, United States
Washington University
St Louis, Missouri, United States
NHO Revive Research Institute, LLC
Lincoln, Nebraska, United States
Cooper Health System MD Anderson Cancer Center at Cooper
Camden, New Jersey, United States
Astera Cancer Care
East Brunswick, New Jersey, United States
Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey, United States
Laura & Isaac Perlmutter Cancer Center at NYU Langone Hospital - Long Island
Mineola, New York, United States
NYU Langone Health Laura and Isaac Perlmutter Cancer Center
New York, New York, United States
Montefiore Medical Center
The Bronx, New York, United States
Duke University Medical Center
Durham, North Carolina, United States
Gabrail Cancer Center
Canton, Ohio, United States
University of Cincinnati
Cincinnati, Ohio, United States
Metrohealth Medical Center
Cleveland, Ohio, United States
Oregon Urology Institute
Springfield, Oregon, United States
Lehigh Valley Hospital
Allentown, Pennsylvania, United States
MidLantic Urology
Bala-Cynwyd, Pennsylvania, United States
Penn State Milton S. Hershey Medical Center
Hershey, Pennsylvania, United States
University Of Pittsburgh Medical Center UPMC Hillman Cancer Center
Pittsburgh, Pennsylvania, United States
Carolina Urologic Research Center
Myrtle Beach, South Carolina, United States
Avera Medical Group
Sioux Falls, South Dakota, United States
Prairie Lakes Health Care System
Watertown, South Dakota, United States
Tennessee Cancer Specialists
Knoxville, Tennessee, United States
Texas Oncology
Austin, Texas, United States
UT Southwestern Medical Center
Dallas, Texas, United States
Houston Metro Urology
Houston, Texas, United States
Texas Oncology 1
Sugar Land, Texas, United States
Renovatio Clinical
The Woodlands, Texas, United States
Virginia Cancer Specialists
Fairfax, Virginia, United States
Fred Hutch Cancer Center Sloan Clinic 2
Seattle, Washington, United States
Fred Hutchinson Cancer Research Center
Seattle, Washington, United States
Warringal Private Hospital
Heidelberg, Australia
Icon Cancer Centre Kurralta Park
Kurralta Park, Australia
Peter MacCallum Cancer Centre
Melbourne, Australia
Sydney Adventist Hospital
Wahroonga, Australia
Princess Alexandra Hospital
Woolloongabba, Australia
AZORG campus Aalst Moorselbaan
Aalst, Belgium
ZAS Augustinus
Antwerp, Belgium
AZ Maria Middelares
Ghent, Belgium
Chu Helora Hospital La Louviere Site Jolimont
La Louvière, Belgium
CHC MontLegia
Liège, Belgium
NAIC Nair Antunes Instituto do Cancer
Bauru, Brazil
Liga Norte Riograndense Contra O Cancer
Natal, Brazil
Hospital Ana Nery Santa Cruz do Sul
Santa Cruz do Sul, Brazil
CEPHO Centro de Estudos e Pesquisa de Hematologia e Oncologia
Santo André, Brazil
Hospital Samaritano de Sao Paulo
São Paulo, Brazil
British Columbia Cancer Agency
Vancouver, British Columbia, Canada
British Columbia Cancer Agency Vancouver Island Centre
Victoria, British Columbia, Canada
The Ottawa Hospital Cancer Centre
Ottawa, Ontario, Canada
Princess Margaret Cancer Centre
Toronto, Ontario, Canada
Centre de Recherche du CHUM
Montreal, Quebec, Canada
CHU de Quebec Universite Laval
Québec, Quebec, Canada
Peking University First Hospital
Beijing, China
Beijing Cancer Hospital
Beijing, China
Beijing Luhe Hospital, Capital Medical University
Beijing, China
The Third People's Hospital of Chengdu
Chengdu, China
West China Hospital Sichuan University
Chengdu, China
Chongqing University Cancer Hospital
Chongqing, China
Sun Yat Sen University Cancer Center
Guangzhou, China
The First Affiliated Hospital of Guangzhou Medical University
Guangzhou, China
Sir Run Run Shaw Hospital Zhejiang University School of Medicine
Hangzhou, China
Nanjing Drum Tower Hospital
Nanjing, China
Huashan Hospital Fudan University
Shanghai, China
Shanghai General Hospital
Shanghai, China
Xinhua hospital,Shanghai Jiaotong University
Shanghai, China
The Second Hospital Of Tianjin Medical University
Tianjin, China