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Symbiotic-GU-08: A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With Locally Advanced or Metastatic Renal Cell Cancer
Sponsor: Pfizer
Summary
This study is testing a new medicine called PF-08634404 and how it works in adults with advanced Renal Cell Carcinoma (RCC)- a type of kidney cancer that is either locally advanced (spread to nearby tissues) or metastatic (spread to other parts of the body). The study will look at the safety of the study medicine, when given alone or with other anticancer medicines, and how this type of cancer responds to them. To join the study, participants must be adults; with locally advanced or metastatic RCC; who have not received treatment for their advanced kidney cancer. Participants will receive study medicine either alone or with other anticancer medicines. The medicine will be given through intravenous (IV) infusions, which means it will be injected directly into a vein. All treatments will take place at clinical study sites, where trained medical staff will take care of participants during and after each visit.
Official title: AN INTERVENTIONAL PHASE 1B/2 STUDY TO EVALUATE THE SAFETY AND EFFICACY OF PF-08634404 MONOTHERAPY AND IN COMBINATION WITH OTHER ANTICANCER AGENTS IN ADULT PARTICIPANTS WITH LOCALLY ADVANCED OR METASTATIC RENAL CELL CARCINOMA
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
224
Start Date
2026-02-10
Completion Date
2028-11-01
Last Updated
2026-10-08
Healthy Volunteers
No
Conditions
Interventions
PF-08634404
Concentrate for solution for infusion
Ipilimumab
Solution for infusion
Axitinib
Tablet
Casdatifan
Tablet
Locations (183)
Mayo Clinic Building- Phoenix
Phoenix, Arizona, United States
Mayo Clinic Arizona
Scottsdale, Arizona, United States
Highlands Oncology Group
Fayetteville, Arkansas, United States
Highlands Oncology Group
Rogers, Arkansas, United States
Highlands Oncology Group, PA
Springdale, Arkansas, United States
UCLA Hematology/Oncology - Alhambra
Alhambra, California, United States
UCLA Hematology/Oncology - Atascadero
Atascadero, California, United States
UCLA Hematology/Oncology - Burbank
Burbank, California, United States
City of Hope (City of Hope National Medical Center, City of Hope Medical Center)
Duarte, California, United States
City of Hope Investigational Drug Services (IDS)
Duarte, California, United States
UC San Diego Medical Center - Encinitas
Encinitas, California, United States
UCLA Hematology/Oncology- Encino
Encino, California, United States
UCLA Hematology/Oncology- Irvine
Irvine, California, United States
City of Hope at Irvine Lennar
Irvine, California, United States
City of Hope Investigational Drug Services (IDS)
Irvine, California, United States
UC San Diego / Moores Cancer Center
La Jolla, California, United States
UC San Diego Koman Family Outpatient Pavilion
La Jolla, California, United States
UC San Diego Medical Center - La Jolla (Jacobs Medical Center / Thornton Pavilion)
La Jolla, California, United States
UC San Diego Sulpizio Cardiovascular Center
La Jolla, California, United States
UCLA Hematology/Oncology - Laguna Hills
Laguna Hills, California, United States
City of Hope
Long Beach, California, United States
Investigational Drug Services, Bowyer Pharmacy
Los Angeles, California, United States
Ronald Reagan UCLA Medical Center, Drug Information Center
Los Angeles, California, United States
UCLA Hematology/Oncology
Los Angeles, California, United States
UCLA Hematology/Oncology - Marina del Rey
Marina del Rey, California, United States
UCLA Hematology/Oncology - Pasadena
Pasadena, California, United States
UCLA Hematology/Oncology - Porter Ranch
Porter Ranch, California, United States
UC San Diego Medical Center - Bankers Hill
San Diego, California, United States
UC San Diego McGrath Outpatient Pavilion - Hillcrest
San Diego, California, United States
UC San Diego Medical Center - Hillcrest
San Diego, California, United States
UC San Diego Medical Center - Rancho Bernardo
San Diego, California, United States
UCLA Hematology/Oncology - San Luis Obispo
San Luis Obispo, California, United States
UCLA Hematology/Oncology- Santa Barbara
Santa Barbara, California, United States
UCLA Hematology/Oncology - Santa Monica
Santa Monica, California, United States
UCLA Hematology/Oncology- Torrance
Torrance, California, United States
City of Hope UPLAND
Upland, California, United States
UCLA Hematology/Oncology - Santa Clarita
Valencia, California, United States
UCLA Hematology/Oncology- Ventura
Ventura, California, United States
UC San Diego Medical Center - Vista
Vista, California, United States
UCLA Hematology/Oncology- Westlake
Westlake Village, California, United States
Rocky Mountain Cancer Centers,LLP
Aurora, Colorado, United States
Clinical and Translational Research Center(CTRC)
Aurora, Colorado, United States
University of Colorado Hospital - Anschutz Inpatient Pavilion (AIP)
Aurora, Colorado, United States
University of Colorado Hospital - Anschutz Outpatient Pavilion (AOP)
Aurora, Colorado, United States
University of Colorado Hospital-Anschutz Cancer Pavilion (ACP)
Aurora, Colorado, United States
UCHealth Cherry Creek Medical Center
Denver, Colorado, United States
Rocky Mountain Cancer Centers,LLP
Denver, Colorado, United States
Highlands Ranch Hospital
Highlands Ranch, Colorado, United States
Rocky Mountain Cancer Centers, LLP
Lakewood, Colorado, United States
Rocky Mountain Cancer Centers,LLP
Lone Tree, Colorado, United States
UC Health Lone Tree Medical Center
Lone Tree, Colorado, United States
Mayo Clinic Pharmacy
Jacksonville, Florida, United States
Orlando Health Cancer Institute
Lake Mary, Florida, United States
Orlando Health Ambulatory Care Center
Orlando, Florida, United States
Orlando Health Cancer Institute
Orlando, Florida, United States
Orlando Health Orlando Regional Medical Center
Orlando, Florida, United States
Tennessee Oncology, PLLC- Ringgold
Ringgold, Georgia, United States
Memorial Hospital
Shiloh, Illinois, United States
Siteman Cancer Center - Shiloh
Shiloh, Illinois, United States
City Of Hope - Chicago
Zion, Illinois, United States
Brigham and Women's Hospital
Boston, Massachusetts, United States
Dana-Farber Cancer Institute
Boston, Massachusetts, United States
Dana-Farber Cancer Institute - Chestnut Hill
Newton, Massachusetts, United States
Minnesota Oncology Hematology, P.A.
Burnsville, Minnesota, United States
Minnesota Oncology Hematology, P.A.
Chaska, Minnesota, United States
Minnesota Oncology Hematology, P.A.
Coon Rapids, Minnesota, United States
Minnesota Oncology Hematology, P.A.
Edina, Minnesota, United States
Minnesota Oncology Hematology, P.A.
Maple Grove, Minnesota, United States
Minnesota Oncology Hematology, P.A.
Maplewood, Minnesota, United States
Mayo Clinic Hospital, Methodist Campus, Research Pharmacy
Rochester, Minnesota, United States
Mayo Clinic Cancer Center Outpatient Pharmacy
Rochester, Minnesota, United States
Minnesota Oncology Hematology, P.A.
Woodbury, Minnesota, United States
Siteman Cancer Center - St. Peters
City of Saint Peters, Missouri, United States
Siteman Cancer Center - West County
Creve Coeur, Missouri, United States
Siteman Cancer Center - North County
Florissant, Missouri, United States
Siteman Cancer Center
St Louis, Missouri, United States
Barnes-Jewish Hospital
St Louis, Missouri, United States
Washington University School of Medicine - Siteman Cancer Center
St Louis, Missouri, United States
Siteman Cancer Center - South County
St Louis, Missouri, United States
MSK Basking Ridge
Basking Ridge, New Jersey, United States
MSK Monmouth
Middletown, New Jersey, United States
MSK Bergen
Montvale, New Jersey, United States
New York Oncology Hematology, P.C.
Albany, New York, United States
New York Oncology Hematology - Clifton Park Cancer Center
Clifton Park, New York, United States
MSK Commack
Commack, New York, United States
MSK Westchester
Harrison, New York, United States
Memorial Sloan Kettering Cancer Center - Investigational Drug Service Pharmacy
Long Island City, New York, United States
Icahn School of Medicine at Mount Sinai
New York, New York, United States
Evelyn H. Lauder Breast and Imaging Center (BAIC)
New York, New York, United States
Memorial Sloan Kettering Cancer Center - Main Campus
New York, New York, United States
Sidney Kimmel Center for Prostate and Urological Cancers - Memorial Sloan Kettering Cancer Center
New York, New York, United States
MSK Nassau
Uniondale, New York, United States
Northwest Cancer Specialists, P.C.
Portland, Oregon, United States
Grand Strand Medical Center
Myrtle Beach, South Carolina, United States
Carolina Urologic Research Center, LLC
Myrtle Beach, South Carolina, United States
Parkway Surgery Center
Myrtle Beach, South Carolina, United States
Tennessee Oncology, PLLC- Chattanooga Downtown
Chattanooga, Tennessee, United States
Tennessee Oncology, PLLC - Chattanooga Med Park II
Chattanooga, Tennessee, United States
Tennessee Oncology, PLLC - Chattanooga Memorial
Chattanooga, Tennessee, United States
Tennessee Oncology, PLLC - Investigational Drug Services/Supply Storage
Chattanooga, Tennessee, United States