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Ongericimab Injection Reducing Recurrence of Ischemic Stroke
Sponsor: Beijing Tiantan Hospital
Summary
The Oris trial aims to evaluate whether the use of Ongericimab injection in patients with atherosclerotic ischemic cerebrovascular disease within 3 months of onset can reduce the risk of recurrent major cardiovascular events by achieving lower lipid-lowering target values (LDL-C \< 1.4 mmol/L).
Official title: A Multicenter, Randomized, Open-label, Parallel-controlled, Event-driven, Blinded-endpoint Trial Evaluating the Efficacy and Safety of Ongericimab Injection in High-risk Stroke Patients With Intracranial or Extracranial Atherosclerotic Stenosis.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
4810
Start Date
2026-04-22
Completion Date
2029-04-01
Last Updated
2026-04-16
Healthy Volunteers
No
Conditions
Interventions
High target group
Standardized lipid-lowering therapy according to the Chinese Stroke Association Guidelines for Clinical Management of Cerebrovascular Diseases to achieve an LDL-C target below 70 mg/dL (1.8 mmol/L)
Low target group
Ongericimab subcutaneous injection once every two weeks (150mg) or every four weeks(300mg) combined with standardized lipid-lowering therapy to achieve an LDL-C target below 55 mg/dL (1.4 mmol/L)
Locations (199)
Fuyang People's Hospital
Fuyang, Anhui, China
The First Affiliated Hospital of Wannan Medical College
Wuhu, Anhui, China
The First Hospital of Fangshan District, Beijing
Beijing, Beijing Municipality, China
Chongqing Sanbo Changan Hospital
Chongqing, Chongqing Municipality, China
The Fifth People's Hospital of Chongqing
Chongqing, Chongqing Municipality, China
The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College
Chongqing, Chongqing Municipality, China
Ningde People's Hospital
Ningde, Fujian, China
Minxian County Hospital of Traditional Chinese Medicine
Dingxi, Gansu, China
Shanghai General Hospital Jiuquan Hospital
Jiuquan, Gansu, China
Gansu Provincial Maternity and Child-care Hospital(Gansu Provincial Central Hospital)
Lanzhou, Gansu, China
The First People's Hospital of Yuzhong County
Lanzhou, Gansu, China
First People's Hospital of Tianshui
Tianshui, Gansu, China
Huizhou First Hospital
Huizhou, Guangdong, China
Huidong People'S Hospital
Huizhou, Guangdong, China
Shaoguan Qujiang District People's Hospital
Shaoguan, Guangdong, China
Wuchuan People's Hospital
Zhanjiang, Guangdong, China
Baise City People's Hospital
Baise City, Guangxi, China
Liuzhou Worker's Hospital
Liuchow, Guangxi, China
Puding County People's Hospital
Anshun, Guizhou, China
The People's Hospital of the Qiandongnan Miao and Dong Autonomous Prefecture
Kaili, Guizhou, China
Tongren People's Hospital
Tongren, Guizhou, China
The Second Affiliated Hospital of Hainan Medical University
Haikou, Hainan, China
Affiliated Hospital of Hebei University
Baoding, Hebei, China
Hebei Tang County People's Hospital
Baoding, Hebei, China
The No.2 Hospital Of Baoding
Baoding, Hebei, China
Cixian People's Hospital
Handan, Hebei, China
Weixian People's Hospital
Handan, Hebei, China
HanDan Central Hospital
Handan, Hebei, China
Qiuxian County People's Hospital
Handan, Hebei, China
Hejian People's Hospital
Hejian, Hebei, China
Hengshui People's Hospital
Hengshui, Hebei, China
The NO.4 People's Hospital of Hengshui
Hengshui, Hebei, China
The NO.4 People's Hospital of Hengshui
Hengshui, Hebei, China
Tianjin Cancer Hospital Qinhuangdao Branch
Qinhuangdao, Hebei, China
The Second Hospital of Qinhuangdao
Qinhuangdao, Hebei, China
The Second Hospital of Hebei Medical University
Shijiazhuang, Hebei, China
Xingtang County People's Hospital
Shijiazhuang, Hebei, China
Xinji Traditional Chinese Medicine Hospital
Shijiazhuang, Hebei, China
Guye District Hospital of Traditional Chinese Medicine, Tangshan
Tangshan, Hebei, China
Yutian County Hospital of Traditional Chinese Medicine
Tangshan, Hebei, China
Xingtai central hospital
Xingtai, Hebei, China
Xingtai People's Hospital
Xingtai, Hebei, China
Weixian People's Hospital
Xingtai, Hebei, China
Qinghe people's hospital
Xingtai, Hebei, China
Xuangang Hospital
Zhangjiakou, Hebei, China
Daqing No.4 hospital
Daqing, Heilongjiang, China
Daqing Oilfield General Hospital
Daqing, Heilongjiang, China
DA QING LongNan Hospital
Daqing, Heilongjiang, China
The First Affiliated Hospital of Harbin Medical University
Harbin, Heilongjiang, China
The 2nd Affiliated Hospital of Harbin Medical University
Harbin, Heilongjiang, China
Beian No.1 People's Hospital
Harbin, Heilongjiang, China
No.1 People'S Hospital of Heihe
Heihe, Heilongjiang, China
The First Affiliated Hospital of Jiamusi University
Jiamusi, Heilongjiang, China
The Hongda Hospital of Jiamusi University
Jiamusi, Heilongjiang, China
Mudanjiang Hospital of Beidahuang Group
Jixi, Heilongjiang, China
The Second Affiliated Hospital of Qiqihar Medical University
Qiqihar, Heilongjiang, China
Hongxinglong Hospital of Beidahuang Group
Shuangyashan, Heilongjiang, China
Hebi Coal Industry (Group) Co., Ltd. General Hospital
Hebi, Henan, China
Jiaozuo Coal Mining Group Co., Ltd. Central Hospital
Jiaozuo, Henan, China
The First Affiliated Hospital of Henan Polytechnic University (Jiaozuo Second People's Hospital)
Jiaozuo, Henan, China
Xiuwu County People's Hospital
Jiaozuo, Henan, China
Qinyang City Hospital of Traditional Chinese Medicine
Jiaozuo, Henan, China
Qinyang People's Hospital
Jiaozuo, Henan, China
Mengzhou Fuxing hospital
Jiaozuo, Henan, China
Mengzhou Hospital of Traditional Chinese Medicine
Jiaozuo, Henan, China
Jiyuan Hospital of Traditional Chinese Medicine
Jiyuan, Henan, China
Luoyang First People's Hospital
Luoyang, Henan, China
Luoyang Central Hospital
Luoyang, Henan, China
The Second Affiliated Hospital of Henan University of Science and Technology
Luoyang, Henan, China
People'S Hospital of Tanghe
Nanyang, Henan, China
Pingdingshan The second people's hospital
Pingdingshan, Henan, China
The First People's Hospital of Pingdingshan
Pingdingshan, Henan, China
Chinese Medicine Hospital Of Puyang
Puyang, Henan, China
Puyang Oilfield General Hospital
Puyang, Henan, China
Puyang People's Hospital
Puyang, Henan, China
Puyang County People's Hospital
Puyang, Henan, China
Nanle People's Hospital
Puyang, Henan, China
Sanmenxia Central Hospital
Sanmenxia, Henan, China
Yellow River Sanmenxia Hospital
Sanmenxia, Henan, China
The First People Hospital of Lingbao
Sanmenxia, Henan, China
Shang Qiu Hospital of Tcm
Shangqiu, Henan, China
People's hospital of NingLing
Shangqiu, Henan, China
Sui county traditional Chinese medicine hospital
Shangqiu, Henan, China
The First Affiliated Hospital of Henan Medical University
Xinxiang, Henan, China
People's Hospital of Xixian
Xinyang, Henan, China
Changge People's Hospital
Xuchang, Henan, China
Xingyang People's Hospital
Zhengzhou, Henan, China
Xinmi Hospital of T.C.M
Zhengzhou, Henan, China
Zhoukou Yongshan Hospital
Zhoukou, Henan, China
Taikang Xian People's Hospital
Zhoukou, Henan, China
The First People's Hospital of Zhumadian
Zhumadian, Henan, China
Zhumadian Central Hospital
Zhumadian, Henan, China
The People's Hospital of Queshan County
Zhumadian, Henan, China
The People's Hospital Of Biyang County
Zhumadian, Henan, China
Zhongnan Hospital of Wuhan University
Wuhan, Hubei, China
Xianning Central Hospital
Xianning, Hubei, China
Taoyuan People'S Hospital
Changde, Hunan, China
Liuyang Jili Hospital
Changsha, Hunan, China
Chenzhou 3rd People's Hospital
Chenzhou, Hunan, China
Chenzhou No.1 People's Hospital
Chenzhou, Hunan, China