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A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer
Sponsor: Incyte Corporation
Summary
The purpose of this study is to evaluate the efficacy and safety of standard-of-care chemotherapy and bevacizumab with or without INCA33890 in the first-line treatment of metastatic microsatellite stable colorectal cancer.
Official title: A Randomized, Double-Blind, Phase 3 Study of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
700
Start Date
2026-03-05
Completion Date
2029-09-28
Last Updated
2026-10-30
Healthy Volunteers
No
Conditions
Interventions
INCA33890
INCA33890 will be administered at protocol defined dose.
Placebo
Placebo will be administered at protocol defined dose.
Bevacizumab
Bevacizumab will be administered at protocol defined dose.
FOLFOX
FOLFOX will be administered at protocol defined dose.
Locations (297)
Mitchell Cancer Institute
Mobile, Alabama, United States
The University of Arizona Cancer Center
Tucson, Arizona, United States
Roche Tissue Diagnostics, Companion Diagnostics
Tucson, Arizona, United States
Memorial Care Orange Coast Medical Center
Fountain Valley, California, United States
Providence Medical Foundation
Fullerton, California, United States
Cancer & Blood Research Center
Los Alamitos, California, United States
University of California Los Angeles Health
Los Angeles, California, United States
Oncura Health
Sacramento, California, United States
Sarah Cannon Research Institute Scri Oncology Partners
Aurora, Colorado, United States
Hartford Hospital
Hartford, Connecticut, United States
George Washington University
Washington D.C., District of Columbia, United States
Florida Oncology & Hematology
Fort Myers, Florida, United States
University of Florida Health
Gainesville, Florida, United States
Sylvester Comprehensive Cancer Center
Miami, Florida, United States
Advent Health
Orlando, Florida, United States
Orlando Health Cancer Institute Downtown Orlando
Orlando, Florida, United States
Ascension Sacred Heart Pensacola
Pensacola, Florida, United States
Tampa General Hospital-Cancer Institute
Tampa, Florida, United States
Total Health Center
Decatur, Georgia, United States
Piedmont Cancer Institute
Locust Grove, Georgia, United States
University of Hawaii Cancer Center
Honolulu, Hawaii, United States
St Lukes Mountain States Tumor Institute Msti Boise
Boise, Idaho, United States
Sih Cancer Institute
Carterville, Illinois, United States
University of Illinois Cancer Center
Chicago, Illinois, United States
Alexian Brothers Medical Center
Elk Grove Village, Illinois, United States
Endeavor Health
Evanston, Illinois, United States
Springfield Clinic
Springfield, Illinois, United States
Community Health Network, Inc.
Indianapolis, Indiana, United States
Hematology Oncology of Indiana
Indianapolis, Indiana, United States
University of Iowa Hospital and Clinics
Iowa City, Iowa, United States
Saint Agnes Hospital
Baltimore, Maryland, United States
Cancer Center For Blood Disorders A Division of American Oncology Partners P.A
Bethesda, Maryland, United States
Sarah Cannon Research Institute Scri Oncology Partners
Brandywine, Maryland, United States
Massachusetts General Hospital
Boston, Massachusetts, United States
Trinity Health St Joseph Mercy Ann Arbor
Ann Arbor, Michigan, United States
Henry Ford Hospital
Detroit, Michigan, United States
Missouri Cancer Associates
Columbia, Missouri, United States
Saint Luke'S Hospital of Kansas City
Kansas City, Missouri, United States
Midamerica Cancer Care
Kansas City, Missouri, United States
Oncology Hematology Associates
Springfield, Missouri, United States
Washington University School of Medicine
St Louis, Missouri, United States
Morristown Medical Center
Morristown, New Jersey, United States
Presbyterian Rust Medical Center
Rio Rancho, New Mexico, United States
Icahn School of Medicine At Mount Sinai
New York, New York, United States
Memorial Sloan Kettering Cancer Center
New York, New York, United States
Ny Cancer and Blood Specialists
Shirley, New York, United States
Montefiore Medical Center
The Bronx, New York, United States
Messino Cancer Center
Asheville, North Carolina, United States
The University of North Carolina At Chapel Hill
Chapel Hill, North Carolina, United States
Oncology Specialists of Charlotte
Charlotte, North Carolina, United States
University of Cincinnati Cancer Institute
Cincinnati, Ohio, United States
Case Comprehensive Cancer Center
Cleveland, Ohio, United States
Ohio State University-Arthur G James Comprehensive Cancer Center
Columbus, Ohio, United States
Ohio Health
Columbus, Ohio, United States
Zangmeister Center
Columbus, Ohio, United States
Taylor Cancer Research Center
Maumee, Ohio, United States
Alliance Cancer Specialists
Doylestown, Pennsylvania, United States
Penn State Milton S. Hershey Medical Center
Hershey, Pennsylvania, United States
University of Pennsylvania
Philadelphia, Pennsylvania, United States
Allegheny General Hospital Cancer Institute
Pittsburgh, Pennsylvania, United States
Hillman Cancer Center
Pittsburgh, Pennsylvania, United States
Cancer Care Associates of York
York, Pennsylvania, United States
Avera Cancer Institute
Sioux Falls, South Dakota, United States
Provision Center For Biomedical Research
Knoxville, Tennessee, United States
Ascension Seton Spclty Care Ctr
Austin, Texas, United States
Texas Oncology
Austin, Texas, United States
University of Texas Southwestern Medical Center
Dallas, Texas, United States
Md Anderson Cancer Center
Houston, Texas, United States
Baylor Scott & White Health
Temple, Texas, United States
University of Virginia Medical Center
Charlottesville, Virginia, United States
Mary Washington Healthcare
Fredericksburg, Virginia, United States
Hematology Oncology Associates of Fredericksburg Admin
Fredericksburg, Virginia, United States
Shenandoah Oncology
Winchester, Virginia, United States
Vista Oncology Inc Ps
Olympia, Washington, United States
Virginia Mason Medical Center
Seattle, Washington, United States
Vandalia Health Charleston Area Medical Center
Charleston, West Virginia, United States
West Virginia University Cancer Institute
Morgantown, West Virginia, United States
Thedacare Medical Oncology
Appleton, Wisconsin, United States
Hospital Britanico de Buenos Aires
Buenos Aires, Argentina
Investigaciones Clinicas Moleculares Icm
Buenos Aires, Argentina
Centro Medico Austral
Ciudad Autonoma Buenos Aires, Argentina
Instituto Medico Especializado Alexander Fleming
Ciudad Autonoma Buenos Aires, Argentina
Hospital Italiano de Buenos Aires
Ciudad Autonoma Buenos Aires, Argentina
Instituto de Investigaciones Clinicas Cordoba S.A.
Córdoba, Argentina
Hospital Privado Centro Medico de Cordoba S.A
Córdoba, Argentina
Centro Oncologico Riojano Integral (Cori)
La Rioja, Argentina
Investigaciones Oncologicas C Colon
Mar del Plata, Argentina
Instituto de Oncologia de Rosario
Rosario, Argentina
Exelsus Srl
San Miguel de Tucumán, Argentina
Port Macquarie Base Hospital
Port Macquarie, New South Wales, Australia
Prince of Wales Hospital Au
Randwick, New South Wales, Australia
Calvary Mater Newcastle
Waratah, New South Wales, Australia
Westmead Hospital
Westmead, New South Wales, Australia
Wollongong Hospital
Wollongong, New South Wales, Australia
Gold Coast University Hospital
Southport, Queensland, Australia
Townsville Cancer Centre
Townsville, Queensland, Australia
Princess Alexandra Hospital Australia
Woolloongabba, Queensland, Australia
Icon Cancer Centre Kurralta Park
Kurralta Park, South Australia, Australia
Box Hill Hospital
Box Hill, Victoria, Australia
Austin Hospital
Heidelberg, Victoria, Australia