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A Clinical Trial of Sac-TMT in People With Non-HRD Positive Advanced Ovarian Cancer (MK-2870-021)
Sponsor: Merck Sharp & Dohme LLC
Summary
Researchers are looking for new ways to treat ovarian cancer (OC). Current treatment for OC may start with surgery to remove as much of the cancer as possible. After surgery, people may receive chemotherapy. After chemotherapy, standard care options may include: * Maintenance treatment, which is used after another therapy to keep the cancer from growing, spreading, or coming back. Bevacizumab is a targeted therapy used as standard maintenance treatment. Targeted therapy works to control how specific types of cancer cells grow and spread. * Observation, which is watching to see if cancer grows or worsens The study medicine, sacituzumab tirumotecan (also called sac-TMT), is a targeted therapy. The goal of this study is to learn if people who receive sac-TMT maintenance treatment with or without bevacizumab live longer without the cancer getting worse than people who receive standard care.
Official title: A Phase 3, Randomized, Open-label, Multicenter Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) Maintenance Treatment With or Without Bevacizumab Versus Standard of Care in Participants With Newly Diagnosed Advanced Non-HRD Positive Ovarian Cancer Following First-line Platinum-based Chemotherapy (TroFuse-021/ENGOTov85/GOG-3102)
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
900
Start Date
2026-02-16
Completion Date
2033-02-25
Last Updated
2026-10-13
Healthy Volunteers
No
Conditions
Interventions
Sacituzumab tirumotecan
Administered via intravenous (IV) infusion at a dose of 4mg/kg
Bevacizumab
Administered via IV infusion at a dose of 15mg/kg
Rescue Medications
Participants must receive prophylactic steroid mouthwash (dexamethasone or equivalent). It is recommended that participants receive the following rescue medications prior to sac-TMT infusion, per approved product label: histamine-1 receptor antagonist, histamine-2 receptor antagonist, acetaminophen or equivalent, and dexamethasone or equivalent.
Locations (167)
University of Alabama - Birmingham ( Site 0058)
Birmingham, Alabama, United States
John Muir Health Cancer Center ( Site 0069)
Walnut Creek, California, United States
Mount Sinai Cancer Center ( Site 0029)
Miami Beach, Florida, United States
Orlando Health Winnie Palmer Hospital for Women and Babies ( Site 0085)
Orlando, Florida, United States
Winship Cancer Institute of Emory University ( Site 0037)
Atlanta, Georgia, United States
Illinois Cancer Specialists (ICS) ( Site 8009)
Arlington Heights, Illinois, United States
Parkview Research Center at Parkview Regional Medical Center ( Site 0055)
Fort Wayne, Indiana, United States
Franciscan Health Indianapolis ( Site 0081)
Indianapolis, Indiana, United States
Women's Cancer Care ( Site 0018)
Covington, Louisiana, United States
Maine Medical Center Research Institute-MaineHealth/Maine Medical Partners - GynOnc ( Site 0060)
Scarborough, Maine, United States
Maryland Oncology Hematology (MOH) ( Site 8002)
Columbia, Maryland, United States
Nebraska Methodist Hospital ( Site 0004)
Omaha, Nebraska, United States
University Of Nebraska Medical Center ( Site 0035)
Omaha, Nebraska, United States
The Center of Hope ( Site 0025)
Reno, Nevada, United States
Womens Cancer Care Associates, LLC ( Site 0023)
Albany, New York, United States
Memorial Sloan Kettering Cancer Center ( Site 0072)
New York, New York, United States
Duke Cancer Center ( Site 0012)
Durham, North Carolina, United States
University of Cincinnati Medical Center ( Site 0042)
Cincinnati, Ohio, United States
Oklahoma Cancer Specialists and Research Institute, LLC ( Site 0007)
Tulsa, Oklahoma, United States
Kaiser Permanente Interstate Medical Office - Central ( Site 0089)
Portland, Oregon, United States
Hospital of the University of Pennsylvania ( Site 0071)
Philadelphia, Pennsylvania, United States
Women & Infants Hospital ( Site 0001)
Providence, Rhode Island, United States
West Cancer Center and Research Institute ( Site 0013)
Germantown, Tennessee, United States
University of Tennessee Medical Center ( Site 0087)
Knoxville, Tennessee, United States
Henry-Joyce Cancer Clinic ( Site 0011)
Nashville, Tennessee, United States
Virginia Cancer Specialists (VCS) ( Site 8012)
Fairfax, Virginia, United States
Virginia Oncology Associates (VOA) ( Site 8013)
Norfolk, Virginia, United States
Hospital Aleman ( Site 2903)
Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
Instituto Alexander Fleming ( Site 2902)
Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
Instituto de Investigaciones Clinicas Mar del Plata ( Site 2901)
Mar del Plata, Buenos Aires, Argentina
Fundación Respirar ( Site 2912)
Buenos Aires, Buenos Aires F.D., Argentina
Sanatorio Parque - Oncología ( Site 2911)
Rosario, Santa Fe Province, Argentina
Instituto de Oncologia de Rosario ( Site 2909)
Rosario, Santa Fe Province, Argentina
Hospital Britanico de Buenos Aires ( Site 2905)
CABA, Argentina
Fundación CORI para la Investigación y Prevención del Cáncer ( Site 2907)
La Rioja, Argentina
Westmead Hospital ( Site 0201)
Westmead, New South Wales, Australia
Gallipoli Medical Research Ltd ( Site 0204)
Brisbane, Queensland, Australia
Epworth Freemasons ( Site 0207)
East Melbourne, Victoria, Australia
Medizinische Universitat Wien ( Site 0102)
Vienna, State of Vienna, Austria
Medizinische Universitaet Innsbruck-Univ.-Klinik f. Gynäkologie und Geburtshilfe ( Site 0101)
Innsbruck, Tyrol, Austria
Grand Hopital de Charleroi ( Site 0303)
Charleroi, Hainaut, Belgium
AZ Maria Middelares ( Site 0302)
Ghent, Oost-Vlaanderen, Belgium
UZ Leuven ( Site 0301)
Leuven, Vlaams-Brabant, Belgium
Obras Sociais Irma Dulce ( Site 0427)
Salvador, Estado de Bahia, Brazil
Liga Norte Riograndense Contra o Cancer ( Site 0417)
Natal, Rio Grande do Norte, Brazil
Hospital São Lucas da PUCRS ( Site 0415)
Porto Alegre, Rio Grande do Sul, Brazil
ANIMI - Unidade de Tratamento Oncologico ( Site 0421)
Lages, Santa Catarina, Brazil
Fundação Faculdade Regional de Medicina de São José do Rio Preto ( Site 0414)
São José do Rio Preto, São Paulo, Brazil
IBCC - Núcleo de Pesquisa e Ensino ( Site 0416)
São Paulo, Brazil
CIUSSS - Saguenay-Lac-Saint-Jean ( Site 0519)
Chicoutimi, Quebec, Canada
Centre Hospitalier de l'Université de Montréal ( Site 0518)
Montreal, Quebec, Canada
McGill University Health Centre ( Site 0516)
Montreal, Quebec, Canada
Clinica Puerto Montt ( Site 0606)
Port Montt, Los Lagos Region, Chile
Fundación Arturo López Pérez ( Site 0607)
Santiago, Region M. de Santiago, Chile
Clínica Alemana de Santiago ( Site 0610)
Santiago, Region M. de Santiago, Chile
Pontificia Universidad Catolica de Chile ( Site 0602)
Santiago, Region M. de Santiago, Chile
Bradfordhill ( Site 0601)
Santiago, Region M. de Santiago, Chile
ONCOCENTRO APYS-ACEREY ( Site 0603)
Viña del Mar, Valparaiso, Chile
Fundacion Colombiana de Cancerología Clinica Vida ( Site 0803)
Medellín, Antioquia, Colombia
FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 0801)
Bogotá, Bogota D.C., Colombia
Sociedad de Oncología Y Hematología del Cesar S.A.S. ( Site 0802)
Valledupar, Cesar Department, Colombia
Instituto Nacional De Cancerologia ( Site 0808)
Bogota, Cundinamarca, Colombia
Oncólogos del Occidente S.A.S. ( Site 0806)
Pereira, Risaralda Department, Colombia
Fakultni Nemocnice Brno Bohunice ( Site 3304)
Brno, Brno-mesto, Czechia
Fakultni nemocnice Ostrava-Gynekologicko-porodnicka klinika ( Site 3303)
Ostrava-Poruba, Ostrava Mesto, Czechia
Fakultni nemocnice Hradec Kralove ( Site 3307)
Hradec Králové, Czechia
Fakultni nemocnice Kralovske Vinohrady ( Site 3306)
Prague, Czechia
Vseobecna fakultni nemocnice v Praze ( Site 3305)
Prague, Czechia
Fakultni nemocnice motol ( Site 3302)
Prague, Czechia
Herlev Hospital ( Site 0902)
Herlev, Capital Region, Denmark
Aalborg Universitetshospital ( Site 0901)
Aalborg, North Denmark, Denmark
Aarhus Universitetshospital, Skejby ( Site 0903)
Aarhus, North Denmark, Denmark
Odense Universitets Hospital ( Site 0904)
Odense, Region Syddanmark, Denmark
Oulun yliopistollinen sairaala ( Site 1003)
Oulu, North Ostrobothnia, Finland
Kuopion Yliopistollinen Sairaala ( Site 1004)
Kuopio, Northern Savonia, Finland
Tampereen yliopistollinen sairaala ( Site 1002)
Tampere, Pirkanmaa, Finland
Turku University Hospital-Department of Obstetrics and Gynecology ( Site 1001)
Turku, Southwest Finland, Finland
CENTRE LEON BERARD ( Site 1101)
Lyon, Auvergne-Rhône-Alpes, France
Hopitaux Universitaires de Strasbourg ( Site 1109)
Strasbourg, Bas-Rhin, France
Institut Paoli Calmettes ( Site 1111)
Marseille, Bouches-du-Rhone, France
Hôpital Privé Des Côtes d'Armor ( Site 1102)
Plérin, Cotes-d Armor, France
CHRU de Brest - Hopital de la Cavale Blanche ( Site 1104)
Brest, Finistere, France
LBM ONCOPOLE CLAUDIUS REGAUD ( Site 1114)
Toulouse, Haute-Garonne, France
Centre Hospitalier Universitaire Dupuytren ( Site 1112)
Limoges, Haute-Vienne, France
Centre Hospitalier Régional Universitaire de Tours - Hôpital Bretonneau ( Site 1105)
Tours, Indre-et-Loire, France
Centre Oscar Lambret ( Site 1106)
Lille, Nord, France
Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne ( Site 1113)
Clermont-Ferrand, Puy-de-Dome, France
Universitätsklinikum Jena ( Site 1211)
Jena, Thuringia, Germany
Alexandra General Hospital of Athens ( Site 0703)
Athens, Attica, Greece
Evgenidion Clinic Agia Trias S.A ( Site 0701)
Athens, Attica, Greece
Agios Loukas Clinic ( Site 0702)
Thessaloniki, Greece
Bacs-Kiskun Varmegyei Oktatokorhaz-Onkoradiologiai Kozpont ( Site 3910)
Kecskemét, Bács-Kiskun county, Hungary
Petz Aladar Egyetemi Oktato Korhaz-Onkológiai Osztály ( Site 3911)
Győr, Győr-Moson-Sopron, Hungary
Semmelweis Egyetem I. Szamu Szuleszeti es Nogyogyaszati Klinika ( Site 3915)
Budapest, Hungary
Országos Onkológiai Intézet-Ngyógyászat ( Site 3913)
Budapest, Hungary
Debreceni Egyetem Klinikai Kozpont-Szülészeti és Nőgyógyászati Klinika ( Site 3912)
Debrecen, Hungary
Cork University Hospital ( Site 1303)
Cork, Ireland
St James Hospital ( Site 1302)
Dublin, Ireland
Rambam Health Care Campus ( Site 1422)
Haifa, Israel
Edith Wolfson Medical Center ( Site 1423)
Holon, Israel