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Postherpetic Neuralgia After Herpes Zoster and Incident Dementia Risk
Sponsor: China Medical University Hospital
Summary
This retrospective observational cohort study uses de-identified electronic health record data from the TriNetX Global Collaborative Network to evaluate whether postherpetic neuralgia after herpes zoster is associated with an increased risk of incident dementia. Adults aged 40 to 120 years with incident herpes zoster between 1 October 2015 and 31 December 2024 are identified using diagnostic codes. Postherpetic neuralgia is defined by International Classification of Diseases, 10th Revision, Clinical Modification (ICD-10-CM) codes B02.22 or B02.29 recorded between 90 and 365 days after the index herpes zoster date, and comparators have no such codes between 90 and 365 days after index. The primary analysis uses 1:1 propensity score matching and a 365-day landmark design, including only individuals alive and free of dementia at the landmark. Time-to-event analyses estimate hazard ratios for incident dementia and related outcomes.
Official title: Postherpetic Neuralgia After Herpes Zoster and Risk of Incident Dementia: Real-World Evidence From an International Matched Cohort With Landmark Analysis
Key Details
Gender
All
Age Range
40 Years - 120 Years
Study Type
OBSERVATIONAL
Enrollment
73404
Start Date
2015-10-01
Completion Date
2026-10-29
Last Updated
2026-11-02
Healthy Volunteers
No
Interventions
Exposure: postherpetic neuralgia
This is an observational study and no treatment is assigned by the investigators. The intervention of interest is exposure status defined by recorded diagnoses of postherpetic neuralgia after herpes zoster, based on ICD-10-CM codes B02.22 or B02.29 within 90 to 365 days after the index herpes zoster date.
Locations (1)
China Medical University Hospital
Taichung, Taichung City, Taiwan