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A Study to Learn About the Study Medicine (PF-08653944) in People With Obesity or Overweight and Type 2 Diabetes (T2D)
Sponsor: Pfizer
Summary
The purpose of this clinical study is to learn about the safety and effects of the study medicine to help adults with obesity or overweight and type 2 diabetes lose weight. Being overweight or obese means carrying too much body weight. Type 2 diabetes is a condition where there is too much sugar in the blood. The study medicine is given by a shot under the skin in the belly area. The participants will be trained to do this at home once every week. About 660 out of 1000 adults will also receive the study medicine and about 330 out of 1000 adults will receive placebo. A placebo does not have any medicine in it but looks just like the medicine being studied. The investigators will compare the experiences of people receiving the study medicine to those of the people who do not. This will help us assess if the study medicine is safe and effective. People will take part in this study for about 21 months. During this time, they will have about 14 study visits at the site and 5 over the phone.
Official title: EVALUATING THE EFFICACY AND SAFETY OF MET097, A FULLY-BIASED ULTRA LONG-ACTING GLP-1RA, IN PEOPLE WITH OVERWEIGHT OR OBESITY AND TYPE 2 DIABETES: A PHASE 3, MULTI-CENTER RANDOMIZED PLACEBO-CONTROLLED TRIAL (VESPER-5)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
1078
Start Date
2026-02-24
Completion Date
2028-05-16
Last Updated
2026-10-13
Healthy Volunteers
No
Interventions
PF-08653944
By Subcutaneous Injection
Placebo
By Subcutaneous Injection
Locations (180)
CenExel Anaheim Clinical Trials
Anaheim, California, United States
Alliance Research Institute
Canoga Park, California, United States
Core Healthcare Group
Cerritos, California, United States
Retina Consultants of Orange County
Fullerton, California, United States
CenExel CNS - Collaborative Neuroscience Research
Los Alamitos, California, United States
DexaFit Los Alamitos
Los Alamitos, California, United States
Retina Consultants of Orange County
Los Alamitos, California, United States
Catalina Research Institute, LLC
Montclair, California, United States
Cure Clinical Research
Orange, California, United States
Rolling Oaks Radiology -Palms
Oxnard, California, United States
Clinical Innovations, Inc dba CITrials
Riverside, California, United States
Lundquist Institute for Biomedical Innovation at Harbor- UCLA Medical Center
Torrance, California, United States
Access Eye Institute
Westlake Village, California, United States
CenExcel Rocky Mountain Clinical Research, LLC
Englewood, Colorado, United States
CenExel Denver CO (Rocky Mountain Clinical Research)
Englewood, Colorado, United States
Neuro-Sight Vision Care
Lakewood, Colorado, United States
AMR Clinical
Fort Myers, Florida, United States
Pedro P. Ylisastigui, MD
Fort Myers, Florida, United States
Private Practice Adjacent to For Eyes Optical
Hialeah, Florida, United States
Miami Eye Institute
Hollywood, Florida, United States
Research Centers of America
Hollywood, Florida, United States
Future Medical Research (Civia Health)
Longwood, Florida, United States
Advanced Clinical Research
Miami, Florida, United States
Indago Research & Health Center, Inc
Miami Lakes, Florida, United States
Optimal Research Sites, LLC
Orange City, Florida, United States
Oviedo Medical Research
Oviedo, Florida, United States
CenExel FCR - ForCare Clinical Research
Tampa, Florida, United States
DelRicht Research
Atlanta, Georgia, United States
CenExel iResearch, LLC
Decatur, Georgia, United States
CenExel iResearch, LLC
Savannah, Georgia, United States
Patient First Clinical Trials (PFCTRIALS)
Lutherville, Maryland, United States
DelRicht Research
Springfield, Missouri, United States
Upgrade Performance Institute
Elkhorn, Nebraska, United States
Quality Clinical Research Inc
Omaha, Nebraska, United States
Eye Consultants PC
Omaha, Nebraska, United States
Primary clinical Research
Papillion, Nebraska, United States
Hassman Research Institute
Marlton, New Jersey, United States
Forum Health_Cary (Civia)
Cary, North Carolina, United States
Eximia EquiHealth Research
Durham, North Carolina, United States
Sahana Optometry PLLC dba Family Eye Wellness
Holly Springs, North Carolina, United States
Burke Primary Care
Morganton, North Carolina, United States
Eximia Research - NC, LLC
Raleigh, North Carolina, United States
Tribe Clinical Research LLC.- Greenville
Greenville, South Carolina, United States
Tribe Clinical Research LLC. - Spartanburg
Spartanburg, South Carolina, United States
Civia Health Goodlettsville
Goodlettsville, Tennessee, United States
Civia Health Nashville
La Vergne, Tennessee, United States
Amarillo Medical Specialists LLP
Amarillo, Texas, United States
Forum Austin (Civia Health)
Austin, Texas, United States
GLRI El Paso Research
El Paso, Texas, United States
Cardiovascular Specialists of Willowbrook
Houston, Texas, United States
Dallas Clinical Research Center (Pillar Clinical Research)
Richardson, Texas, United States
Pantheon Clinical Research
Bountiful, Utah, United States
CenExel Salt Lake City UT (JBR Clinical Research)
Salt Lake City, Utah, United States
Murray Vision Center PC
Salt Lake City, Utah, United States
ERA Health Research
Redmond, Washington, United States
Centro de Investigaciones Metabólicas (CINME)
Buenos Aires, Argentina
CEDIC
Buenos Aires, Argentina
Centro Medico Viamonte
Buenos Aires, Argentina
Clinica Privada Velez Sarsfield
Córdoba, Argentina
Instituto de Investigaciones Clinicas Cordoba
Córdoba, Argentina
CIDIM
Córdoba, Argentina
CIPADI - Centro Integral de Prevencion Y Atencion en Diabetes
Godoy Cruz, Argentina
Centro de Investigaciones Médicas Tucuman
San Miguel de Tucumán, Argentina
Instituto Medico Catamarca (IMEC)
Santa Fe, Argentina
MHAT Botevgrad
Botevgrad, Bulgaria
Medical Center 4 Life EOOD, Burgas
Burgas, Bulgaria
Multiprofile Hospital for Active Treatment Dobrich AD (MHAT Dobrich AD)
Dobrich, Bulgaria
Medical Center New Polyclinic Gabrovo Ltd.
Gabrovo, Bulgaria
Medical Center Zdrave 1
Kozloduy, Bulgaria
MHAT Sveta Karidad EAD
Plovdiv, Bulgaria
Medical Center Futuremeds EOOD
Plovdiv, Bulgaria
Diagnostic Consultative Center Aleksandrovska
Sofia, Bulgaria
Medical Center Hera EOOD
Sofia, Bulgaria
Prevencia - 2000 - Medical Center for Prehospital Medical Care OOD
Stara Zagora, Bulgaria
Medical Center - Clinic Nova EOOD
Varna, Bulgaria
Medical Centre "Pratia Clinic" EOOD
Varna, Bulgaria
MC Nevromedics Ltd.
Veliko Tarnovo, Bulgaria
Medical Center Berbatov
Yambol, Bulgaria
Centricity Research Etobicoke Endocrinology
Etobicoke, Ontario, Canada
The Wharton Medical Clinic Clinical Trials Inc
Hamilton, Ontario, Canada
LMC Diabetes & Endocrinology - Bayview (Centricity Research Toronto LMC Multispecialty)
Toronto, Ontario, Canada
Centricity Research Mirabel Multispecialty (Centricity Research)
Mirabel, Quebec, Canada
Diacentrum Brandys n.L.
Brandys Nad Lebem, Czechia
Edumed s.r.o.
Náchod, Czechia
CCR Ostrava
Ostrava, Czechia
Pratia Pardubice
Pardubice, Czechia
Fakultní nemocnice Královské Vinohrady
Prague, Czechia
Synexus/Trialmed Prague
Prague, Czechia
ResTrial s.r.o.
Prague, Czechia
CDG Studienambulanz Hartard
Munich, Bavaria, Germany
Studienzentrum FMZ Radowsky
Leipzig, Saxony, Germany
Klinische Forschung Berlin-Mitte GmbH
Berlin, Germany
FutureMeds Berlin
Berlin, Germany
Velocity Clinical Research Germany
Berlin, Germany
Klinische Forschung Dresden GmbH / Pratia
Dresden, Germany
Medizentrum Essen Borbeck
Essen, Germany
Praxis am Markt - Dr. Bernd Becker
Essen, Germany
Klinische Forschung Hamburg GmbH / Pratia
Hamburg, Germany
Diabeteszentrum Hamburg-West
Hamburg, Germany
Praxis Reinfeld Mitte
Holstein, Germany