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A Solid Tumor Study for Long Term Treatment of Cancer Patients Who Participated in Adagrasib Studies
Sponsor: Mirati Therapeutics Inc.
Summary
This is an open-label, solid tumor, continuation, rollover trial which enrolls participants from ongoing BMS parent studies that evaluated adagrasib (MRTX849, BMS-986503) either as monotherapy or in combination with other cancer therapies in patients with non-small cell lung cancer (NSCLC), colorectal cancer (CRC) and other advanced solid tumors.
Official title: Solid Tumor Study for Long Term Treatment of Cancer Patients Who Have Participated in BMS Parent Studies Investigating Adagrasib (BMS-986503)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
170
Start Date
2026-05-06
Completion Date
2028-02-16
Last Updated
2026-10-27
Healthy Volunteers
No
Conditions
Interventions
Adagrasib
Specified dose on specified days
Pembrolizumab
Specified dose on specified days
Cetuximab
Specified dose on specified days
Pemetrexed
Specified dose on specified days
Docetaxel
Specified dose on specified days
Irinotecan
Specified dose on specified days
Leucovorin
Specified dose on specified days
Oxaliplatin
Specified dose on specified days
Fluorouracil
Specified dose on specified days
Locations (101)
Local Institution - 0005
Phoenix, Arizona, United States
Southern California Permanente Medical Group
Bellflower, California, United States
MemorialCare - Long Beach Medical Center
Long Beach, California, United States
Local Institution - 0003
Newark, Delaware, United States
Florida Cancer Specialists - North
St. Petersburg, Florida, United States
Cancer Center of Kansas
Wichita, Kansas, United States
Local Institution - 0092
Boston, Massachusetts, United States
Local Institution - 0080
Boston, Massachusetts, United States
Mayo Clinic in Rochester, Minnesota
Rochester, Minnesota, United States
Metro-Minnesota Community Oncology Research Consortium (MMCORC)
Saint Paul, Minnesota, United States
Nebraska Cancer Specialists
Omaha, Nebraska, United States
Oncology Associates Of Oregon, Pc
Eugene, Oregon, United States
The West Clinic, PLLC dba West Cancer Center
Germantown, Tennessee, United States
Texas Oncology-Bedford
Bedford, Texas, United States
Texas Oncology - Baylor Charles A. Sammons Cancer Center
Dallas, Texas, United States
Texas Oncology - DFW
Grapevine, Texas, United States
PeaceHealth St. Joseph Medical Center
Bellingham, Washington, United States
Local Institution - 0093
St Leonards, New South Wales, Australia
AZ Maria Middelares
Ghent, Belgium
ICESP - INSTITUTO DO CÂNCER DO ESTADO DE SÃO PAULO-Clinical Oncology
São Paulo, Brazil
Fundacao Antonio Prudente - AC Camargo Cancer Center
São Paulo, Brazil
BC Cancer - Vancouver
Vancouver, British Columbia, Canada
Local Institution - 0037
Beijing, Beijing Municipality, China
Local Institution - 0045
Xiamen, Fujian, China
Local Institution - 0042
Zhengzhou, Henan, China
Local Institution - 0038
Changsha, Hunan, China
Local Institution - 0046
Nanjing, Jiangsu, China
Local Institution - 0048
Nanchang, Jiangxi, China
Local Institution - 0049
Shenyang, Liaoning, China
Local Institution - 0039
Jinan, Shandong, China
Local Institution - 0047
Linyi, Shandong, China
Local Institution - 0043
Shanghai, Shanghai Municipality, China
Local Institution - 0040
Chengdu, Sichuan, China
Local Institution - 0044
Hangzhou, Zhejiang, China
Local Institution - 0041
Xi'an, China
Centre Hospitalier Universitaire de Nice - Hopital Pasteur
Nice, Alpes-Maritimes, France
Centre Antoine-Lacassagne
Nice, Alpes-Maritimes, France
Nouvel Hôpital Civil (NHC)
Strasbourg, Alsace, France
CHU Bordeaux Haut-Leveque
Pessac, Aquitaine, France
Chu Jean Minjoz
Besançon, Doubs, France
Chu Grenoble Alpes
La Tronche, Isère, France
Local Institution - 0063
Saint-Herblain, Loire-Atlantique, France
Institut de Cancérologie de l'Ouest
Saint-Herblain, Loire-Atlantique, France
ICO Papin
Angers, Maine-et-Loire, France
Hospices Civils de Lyon - Hopital Louis Pradel
Bron, Rhône, France
L Hopital Nord Ouest
Gleizé, Rhône, France
Local Institution - 0051
Poitiers, Vienne, France
Centre Hospitalier Intercommunal de Créteil
Créteil, France
Assistance Publique Hôpitaux de Marseille - Hôpital Nord
Marseille, France
Centre Hospitalier de Cornouaille Quimper - Concarneau
Quimper, France
Hôpital d'Instruction des Armées Bégin
Saint-Mandé, France
Centre Hospitalier Régional Universitaire de Tours - Hôpital Bretonneau
Tours, France
Groupe hospitalier Paris saint Joseph
Paris, Île-de-France Region, France
Klinikum Neuperlach
München, Germany
Alexandra General Hospital of Athens
Athens, Attikí, Greece
Theagenio Hospital
Thessaloniki, Kentrikí Makedonía, Greece
Metropolitan Hospital
Attiki, Greece
Orszagos Koranyi Pulmonologiai Intezet
Budapest, Hungary
Orszagos Onkologiai Intezet
Budapest, Hungary
Shaare Zedek Medical Center
Jerusalem, Jerusalem, Israel
Bnai Zion Medical Center
Haifa, Israel
Tel Aviv Sourasky Medical Center - Oncology - Hematology/Oncology
Tel Aviv, Israel
IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"
Meldola, Emilia-Romagna, Italy
Azienda Sanitaria Territoriale Pesaro Urbino (AST PU)
Pesaro, Pesaro E Urbino, Italy
Azienda Ospedaliero-Universitaria San Luigi Gonzaga
Orbassano, Piedmont, Italy
Istituto Nazionale Tumori Regina Elena
Rome, Roma, Italy
Azienda Ospedaliera Universitaria Careggi
Florence, Tuscany, Italy
AO Santa Maria della Misericordia
Perugia, Umbria, Italy
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola
Bologna, Italy
Istituto Europeo di Oncologia IRCCS
Milan, Italy
Istituto Europeo di Oncologia IRCCS
Milan, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore
Roma, Italy
Ehime University Hospital
Tōon, Ehime, Japan
Local Institution - 0056
Breda, North Brabant, Netherlands
Nederlands Kanker Instituut Antoni van Leeuwenhoek (NKI AVL)
Amsterdam, North Holland, Netherlands
Ziekenhuis St. Jansdal
Harderwijk, Netherlands
St. Antonius Ziekenhuis, locatie Utrecht
Utrecht, Netherlands
Uniwersyteckie Centrum Kliniczne-Early Clinical Trials Unit
Gdansk, Poland
Instituto Português de Oncologia de Lisboa Francisco Gentil
Lisbon, Lisbon District, Portugal
Local Institution - 0060
Craiova, Dolj, Romania
National Cancer Centre Singapore
Singapore, Singapore
National Cancer Center
Goyang-si, Kyǒnggi-do, South Korea
Severance Hospital, Yonsei University Health System
Seoul, Seoul-teukbyeolsi [Seoul], South Korea
Samsung Medical Center
Seoul, South Korea
CHUAC-Complejo Hospitalario Universitario A Coruña
A Coruña, A Coruña [La Coruña], Spain
Hospital Universitari Son Espases
Palma, Balears [Baleares], Spain
Hospital Universitari Dexeus
Barcelona, Barcelona [Barcelona], Spain
Hospital Universitari Vall d'Hebron
Barcelona, Barcelona [Barcelona], Spain
Institut Catala d'Oncologia-Hospital Germans Trias i Pujol
Badalona, Barcelona, Spain
Hospital Universitario Ramón y Cajal
Madrid, Madrid, Comunidad de, Spain
Clinica Universidad de Navarra
Pamplona, Navarre, Spain
Hospital Clinico de Valencia
Valencia, Valenciana, Comunitat, Spain
Hospital Universitario Reina Sofia
Córdoba, Spain
Hospital General Universitario Gregorio Marañon
Madrid, Spain
Hospital Universitario Fundacion Jimenez Diaz
Madrid, Spain
Hospital Universitario 12 De Octubre
Madrid, Spain
H.R.U Málaga - Hospital General
Málaga, Spain
Hospital Universitario Virgen Macarena
Seville, Spain
Guy's & St Thomas' NHS Foundation Trust
London, London, City of, United Kingdom
University Hospitals Birmingham NHS Foundation Trust - Heartlands Hospital
Birmingham, United Kingdom