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LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis
Sponsor: Eli Lilly and Company
Summary
The main purpose of this study is to evaluate the safety and effectiveness of LY4268989 when compared to placebo in adult participants with moderately to severely active ulcerative colitis (UC). The study drug will be administered orally. The study will last up to approximately 108 weeks, excluding screening.
Official title: A Randomized, Multicenter, Double-Blind, Placebo-Controlled Development Program to Evaluate the Efficacy and Safety of LY4268989 (MORF-057) for the Treatment of Adults With Moderately to Severely Active Ulcerative Colitis (EMERALD-3)
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
1431
Start Date
2026-03-26
Completion Date
2031-07
Last Updated
2026-10-08
Healthy Volunteers
No
Conditions
Interventions
LY4268989
Administered orally
Placebo
Administered orally
Locations (258)
Valleywise Health Medical Center
Phoenix, Arizona, United States
One of a Kind Clinical Research Center
Scottsdale, Arizona, United States
Clinnova Research
Anaheim, California, United States
GMC Clinical Research
Folsom, California, United States
Om Research LLC
Temple City, California, United States
Om Research LLC
Victorville, California, United States
Peak Gastroenterology Associates
Colorado Springs, Colorado, United States
Advanced Research Institute - Denver
Denver, Colorado, United States
Rocky Mountain Gastroenterology Associates - Lakewood
Lakewood, Colorado, United States
Medical Research Center of Connecticut
Hamden, Connecticut, United States
K2 Medical Research - Daytona Beach
Daytona Beach, Florida, United States
Clinical Research of Osceola
Kissimmee, Florida, United States
Florida Research Institute
Lakewood Rch, Florida, United States
AdventHealth Orlando
Orlando, Florida, United States
Treasure Valley Medical Research
Boise, Idaho, United States
Grand Teton Research Group
Idaho Falls, Idaho, United States
Northwestern University
Chicago, Illinois, United States
Rush University Medical Center
Chicago, Illinois, United States
Midwest Digestive Health & Nutrition
Des Plaines, Illinois, United States
Springfield Clinic - First
Springfield, Illinois, United States
Gastroenterology Health Partners
New Albany, Indiana, United States
Gastroenterology Health Partners
Louisville, Kentucky, United States
GI Alliance - Gastro Group and Endocenter - Mandeville
Mandeville, Louisiana, United States
Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinical Research Center
Wyoming, Michigan, United States
Mayo Clinic in Rochester, Minnesota
Rochester, Minnesota, United States
KAD Clinical Research
St Louis, Missouri, United States
Specialists in Gastroenterology
St Louis, Missouri, United States
Digestive Disease Specialists - Las Vegas - Crimson Canyon Drive
Las Vegas, Nevada, United States
Virtua Health & Wellness Center - Moorestown
Moorestown, New Jersey, United States
Saint Peter's University Hospital
New Brunswick, New Jersey, United States
Stony Brook University
Stony Brook, New York, United States
Carolina Digestive Diseases and Endoscopy Center
Greenville, North Carolina, United States
Wilmington Health, PLLC
Wilmington, North Carolina, United States
Ohio State University
Hilliard, Ohio, United States
DSI Research, LLC d/b/a ObjectiveHealth Clinical Research - Springboro
Springboro, Ohio, United States
Gastro Intestinal Research Institute of Northern Ohio, LLC
Westlake, Ohio, United States
The Oregon Clinic
Portland, Oregon, United States
Medical University of South Carolina
Charleston, South Carolina, United States
Sanford USD Medical Center
Sioux Falls, South Dakota, United States
Skyline Gastroenterology of West Tennessee
Jackson, Tennessee, United States
GI Alliance - Fort Worth
Fort Worth, Texas, United States
GI Alliance - Garland
Garland, Texas, United States
Integrity Advanced Therapeutics
Houston, Texas, United States
GI Alliance: Mansfield
Mansfield, Texas, United States
Southern Star Research Institute
San Antonio, Texas, United States
GI Alliance - San Marcos
San Marcos, Texas, United States
Tyler Research Institute
Tyler, Texas, United States
Eximia Research-VA, LLC
Norfolk, Virginia, United States
Swedish Medical Center
Seattle, Washington, United States
Principle Research Solutions
Spokane, Washington, United States
Providence Sacred Heart Medical Center & Children's Hospital
Spokane, Washington, United States
Washington Gastroenterology - Tacoma
Tacoma, Washington, United States
Stat Research S.A.
Buenos Aires, Argentina
Mautalen Salud e Investigación
Buenos Aires, Argentina
GEDYT
Buenos Aires, Argentina
Sanatorio Maipú
Mendoza, Argentina
CER medical Institute
Quilmes, Argentina
INECO Neurociencias Oroño
Rosario, Argentina
Hospital Provincial del Centenario
Rosario, Argentina
Instituto Médico de Alta Complejidad San Isidro Sa
San Isidro, Argentina
C.I.C.E. 9 de Julio
San Miguel de Tucumán, Argentina
Loema Instituto de Pesquisa Clinica
Campinas, Brazil
Fundação Universidade de Caxias do Sul (FUCS)
Caxias do Sul, Brazil
HNSG
Curitiba, Brazil
Centro de Oncologia Leonardo Da Vinci - ATO Terapias
Fortaleza, Brazil
Hospital Ernesto Dornelles
Porto Alegre, Brazil
Instituto D'Or de Pesquisa e Ensino (IDOR) - Filial Salvador
Salvador, Brazil
Irmandade da Santa Casa da Misericórdia de Santos
Santos, Brazil
BR Trials - Ensaios Clinicos e Consultoria
São Paulo, Brazil
Clínica Hepatogastro JK
São Paulo, Brazil
BRA - Clínica Médica e Terapia Assistida
Tajaí, Brazil
Health Sciences North
Greater Sudbury, Canada
QEII Health Sciences Centre - Victoria General Site
Halifax, Canada
London Digestive Disease Institute
London, Canada
Binzhou Medical University Hospital
Binzhou, China
Changzhou Second People's Hospital
Changzhou, China
Sichuan Provincial People's Hospital
Chengdu, China
Chongqing General Hospital
Chongqing, China
The First People's Hospital of Foshan
Foshan, China
The Sixth Affiliated Hospital of Sun Yat-sen University
Guangzhou, China
Heilongjiang Provincial Hospital
Harbin, China
The First Affiliated Hospital of Anhui Medical University
Hefei, China
Huizhou Central People's Hospital
Huizhou, China
First Affiliated Hospital of Kunming Medical University
Kunming, China
Liaocheng People's Hospital
Liaocheng, China
Meihekou Central Hospital
Meihekou, China
The Affiliated Hospital of Qingdao University
Qingdao, China
Shanghai Tenth People's Hospital
Shanghai, China
Shanghai Pudong New District Zhoupu Hospital
Shanghai, China
Yuebei People's Hospital Guangdong
Shaoguan, China
Peking University Shenzhen Hospital
Shenzhen, China
The First Affiliated Hospital of Soochow University
Suzhou, China
Taian City Central Hospital
Taian, China
Wuhan Union Hospital
Wuhan, China
Renmin Hospital of Wuhan University
Wuhan, China
Zunyi Medical College - No.1 Affiliated Hospital
Zunyi, China
Clinica de la Costa S.A.S.
Barranquilla, Colombia
Fundacion Santa Fe de Bogota
Bogotá, Colombia
Hospital Universitario Mayor Méderi
Bogotá, Colombia
Hospital Universitario San Ignacio
Bogotá, Colombia