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An Open Label Extension (OLE) Study (Following Completion of CTQJ230A12301) to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230)
Sponsor: Novartis Pharmaceuticals
Summary
This open-label extension study provides post-trial access to pelacarsen (TQJ230) to participants who have successfully completed the double-blind parent study (CTQJ230A12301). Study has been terminated by sponsor following the outcome of the Lp(a)HORIZON study (NCT04023552), which did not meet its primary endpoint.
Official title: A Single Arm, Multicenter, Open-label Extension (OLE) Trial to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230) in Participants Who Completed the Parent Lp(a)HORIZON Trial
Key Details
Gender
All
Age Range
18 Years - 100 Years
Study Type
INTERVENTIONAL
Enrollment
5700
Start Date
2026-05-11
Completion Date
2030-01-09
Last Updated
2026-10-14
Healthy Volunteers
No
Interventions
Pelacarsen (TQJ230)
pelacarsen 80mg s.c. monthly
Locations (646)
SEC Clinical Research LLC
Andalusia, Alabama, United States
Heart Center Research Llc
Huntsville, Alabama, United States
Mobile Heart Specialists
Mobile, Alabama, United States
Mercy Gilbert Medical Center
Gilbert, Arizona, United States
Clinical Research Inst of Arizona
Sun City West, Arizona, United States
Eclipse Clinical Research
Tucson, Arizona, United States
Cardiology and Medicine Clinic PA
Little Rock, Arkansas, United States
Cardiovascular Res Found
Beverly Hills, California, United States
National Heart Institute
Beverly Hills, California, United States
Valley Clinical Trials Inc
Covina, California, United States
Diabetes Lipid Management Center
Huntington Beach, California, United States
University of Calif Irvine Med Cntr
Irvine, California, United States
Memorial Care Health System
Long Beach, California, United States
Keck Medical Center USC
Los Angeles, California, United States
Valley Clinical Trials
Northridge, California, United States
Stanford University Medical Center
Palo Alto, California, United States
University of California San Diego
San Diego, California, United States
UCSF
San Francisco, California, United States
Manshadi Heart Institute
Stockton, California, United States
Interv Cardiology Med Grp
West Hills, California, United States
Univ Of Color Anschutz Med Center
Aurora, Colorado, United States
Bridgeport Hospital
Bridgeport, Connecticut, United States
Hartford Hospital
Hartford, Connecticut, United States
Chase Medical Research LLC
Waterbury, Connecticut, United States
Excel Medical Clinical Trials LLC
Boca Raton, Florida, United States
Bay Area Cardiology Assoc
Brandon, Florida, United States
Jacksonville Center for Clinical Research
Jacksonville, Florida, United States
Advanced Research for Health Improvement LLC
Naples, Florida, United States
Peace River Cardiovascular Center
Port Charlotte, Florida, United States
Progressive Medical Research
Port Orange, Florida, United States
East Coast Inst for Research LLC
Saint Augustine, Florida, United States
Cardiology Partners Clinical Research Institute
Wellington, Florida, United States
Piedmont Heart Institute
Atlanta, Georgia, United States
Emory University
Atlanta, Georgia, United States
Cardiovascular Consultants of S GA
Thomasville, Georgia, United States
Rush University Medical Center
Chicago, Illinois, United States
Advocate Lutheran General Childrens Hospital
Park Ridge, Illinois, United States
Krannert Institute of Cardiology
Indianapolis, Indiana, United States
Uni Of Iowa Hospitals And Clinics
Iowa City, Iowa, United States
University of Kansas Hospital
Kansas City, Kansas, United States
Cotton O Neil Clinical Res Center
Topeka, Kansas, United States
Cardiovascular Associates Research
Covington, Louisiana, United States
Louisiana Heart Center Research
Covington, Louisiana, United States
CV Institute of the South
Houma, Louisiana, United States
Omega Clinical Research
Metairie, Louisiana, United States
Tulane Center for Clinical Research
New Orleans, Louisiana, United States
CV Ins of the South
Opelousas, Louisiana, United States
Grace Research Llc
Shreveport, Louisiana, United States
Louisiana Heart Center Research
Slidell, Louisiana, United States
Southern Clinical Research
Zachary, Louisiana, United States
Maine Health Cardiology
Scarborough, Maine, United States
University of Maryland
Baltimore, Maryland, United States
Sinai Ct for Throm Res and Drug Dev
Baltimore, Maryland, United States
Johns Hopkins Univ School of Med
Baltimore, Maryland, United States
Johns Hopkins University
Columbia, Maryland, United States
Anderson Medical Research
Ft. Washington, Maryland, United States
Adventist HealthCare Shady Grove Medical Center
Rockville, Maryland, United States
MGH
Boston, Massachusetts, United States
Brigham and Womens Hosp Harvard Med School
Boston, Massachusetts, United States
Wayne State University
Detroit, Michigan, United States
Henry Ford Hospital
Detroit, Michigan, United States
AA Medical Research Center
Flint, Michigan, United States
Western Michigan University
Kalamazoo, Michigan, United States
McLaren Ctr Research Innovation
Petoskey, Michigan, United States
Central Michigan University
Saginaw, Michigan, United States
Metro Health Univ of MI Health
Wyoming, Michigan, United States
Saint Johns Hospital
Maplewood, Minnesota, United States
Minneapolis Heart Institute
Minneapolis, Minnesota, United States
University Of Minnesota
Minneapolis, Minnesota, United States
Belzoni Clinical Research
Belzoni, Mississippi, United States
Stern Cardiovascular Foundation Inc
Southaven, Mississippi, United States
StudyMetrix Research
City of Saint Peters, Missouri, United States
Washington Univ School Of Medicine
St Louis, Missouri, United States
Mercy Hospital St Louis
St Louis, Missouri, United States
Quality Clinical Research
Omaha, Nebraska, United States
Dartmouth Hitchcock Medical Center
Lebanon, New Hampshire, United States
The Valley Hospital
Ridgewood, New Jersey, United States
Overlook Medical Center
Summit, New Jersey, United States
Northwell Health
Manhasset, New York, United States
Weill Cornell Medical Center
New York, New York, United States
Icahn School of Med at Mt Sinai
New York, New York, United States
Lenox Hill Hospital
New York, New York, United States
Northwell Health Physician Peconic
Riverhead, New York, United States
Novant Health Heart Vas Inst
Charlotte, North Carolina, United States
Medication Management LLC
Greensboro, North Carolina, United States
Accellacare US Inc
Raleigh, North Carolina, United States
Wake Forest University Baptist Medical Center
Winston-Salem, North Carolina, United States
Akron Hospital Summa Health System
Akron, Ohio, United States
Aultman Hospital
Canton, Ohio, United States
Lindner Ctr At The Christ Hosp
Cincinnati, Ohio, United States
Cleveland Clinic Foundation
Cleveland, Ohio, United States
Ohio State University
Columbus, Ohio, United States
Rama Research LLC
Marion, Ohio, United States
Lancaster General Health
Lancaster, Pennsylvania, United States
Perelman School of Medicine
Philadelphia, Pennsylvania, United States
Allegheny General Hospital
Pittsburgh, Pennsylvania, United States
Cardiology Consultants of Philadelphia
Yardley, Pennsylvania, United States
Monument Health Clinical Research
Rapid City, South Dakota, United States
The Stern Cardiovascular Foundation
Germantown, Tennessee, United States
Apex Cardiology Research Associates of Jackson
Jackson, Tennessee, United States