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Effects of a Dietary Supplement on Collagen Production and Evaluation of Its Regenerative and Anti-Ageing Propertiess
Sponsor: Marianna Kapetanou
Summary
This study evaluates the effects of a dietary supplement containing natural bioactive compounds on biological processes associated with skin ageing and extracellular matrix integrity. Ageing is characterized by a progressive decline in the function of dermal fibroblasts, the primary cells responsible for collagen production and maintenance of skin structure. Over time, these cells exhibit reduced proliferative capacity, decreased collagen synthesis, and increased accumulation of oxidative and glycative damage, leading to deterioration of skin elasticity and overall tissue homeostasis. The study integrates in vitro and clinical approaches to investigate the potential benefits of the formulation. In the clinical component, healthy adult participants received either the nutraceutical formulation or a matched placebo daily for a period of six weeks. Blood samples were collected at baseline and at the end of the intervention to assess changes in systemic biomarkers associated with collagen metabolism, oxidative stress, and glycation. Specifically, the study measured circulating levels of Pro-Collagen I Alpha as an indicator of collagen biosynthesis, protein carbonyls as markers of oxidative protein damage, and Advanced Glycation End Products as markers of glycation-related molecular damage. These biomarkers collectively reflect key biological mechanisms underlying skin ageing and broader ageing processes. The objective of the study is to determine whether supplementation with the formulation can support extracellular matrix homeostasis, enhance collagen production, and reduce molecular damage associated with oxidative stress and glycation, thereby contributing to healthy ageing.
Key Details
Gender
All
Age Range
29 Years - 82 Years
Study Type
INTERVENTIONAL
Enrollment
92
Start Date
2025-10-01
Completion Date
2026-03-01
Last Updated
2026-04-09
Healthy Volunteers
Yes
Interventions
Collagen-Supporting Nutraceutical Formulation
The intervention consists of an oral dietary supplement formulated to support collagen biosynthesis and extracellular matrix homeostasis. Each tablet contains hydrolyzed marine collagen peptides, hyaluronic acid, and amino acids (glycine, proline, hydroxyproline) involved in collagen formation and stabilization. The formulation also includes antioxidant compounds (quercetin, reduced glutathione, astaxanthin) to support redox balance, as well as vitamin C and zinc as cofactors in collagen synthesis. Additional components include vitamin D3 and biotin to support cellular and skin health. The supplement is administered daily for six weeks.
Placebo
The placebo consists of an inert oral formulation matched in appearance and administration schedule to the active dietary supplement. It contains excipients without active bioactive ingredients and is administered daily for six weeks.
Locations (1)
Hellenic Pasteur Institute
Athens, Attica, Greece