Clinical Research Directory

Inclusion Criteria: * Gestational age ≥36 weeks * Therapeutic hypothermia initiated within the first 6 hours after birth for hypoxic-ischemic encephalopathy * Moderate or severe hypoxic-ischemic encephalopathy according to the modified Sarnat classification * Evidence of perinatal hypoxia, including umbilical cord or early postnatal blood gas pH ≤7.00 or base excess ≤-16 mmol/L within the first hour of life, or a 10-minute Apgar score \<5 or ongoing resuscitation * Not receiving invasive mechanical ventilation * Clinically stable for the intervention as determined by the attending neonatologist * Written informed consent obtained from a parent or legal guardian Exclusion Criteria: * Invasive mechanical ventilation * Major congenital anomaly * Severe intracranial hemorrhage * Multiple organ failure * Skin lesion, trauma, or vascular access involving the lower extremities that could interfere with foot reflexology * Active resuscitation * Severe hemodynamic instability * Uncontrolled seizures or neurological deterioration compromising intervention safety * Any clinical event or device/airway/vascular access concern preventing safe administration of the intervention