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Atebimetinib + GnP as a First Line Treatment in Patients With Metastatic Pancreatic Adenocarcinoma
Sponsor: Immuneering Corporation
Summary
The purpose of this study is to evaluate the safety and efficacy of atebimetinib in combination with modified GnP compared with SOC GnP alone.
Official title: A Phase 3 Randomized, Open-Label Study of Atebimetinib in Combination With the Modified Gemcitabine and Nab-Paclitaxel Regimen Versus the Standard Gemcitabine and Nab-Paclitaxel Regimen for the Treatment of Patients With Metastatic Pancreatic Ductal Pancreatic Adenocarcinoma Cancer (MAPKeeper 301)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
570
Start Date
2026-06-05
Completion Date
2029-02
Last Updated
2026-11-02
Healthy Volunteers
No
Conditions
Interventions
Atebimetinib
Once daily oral tablets
GnP
Standard of care regimen for intravenous infusions of gemcitabine and nab-paclitaxel weekly for three weeks followed by one week without an infusion
mGnP
Biweekly intravenous infusions of chemotherapy (gemcitabine and nab-paclitaxel)
Locations (72)
Clearview Cancer Institute
Huntsville, Alabama, United States
City of Hope
Phoenix, Arizona, United States
City of Hope
Duarte, California, United States
University of California San Diego
San Diego, California, United States
Poudre Valley Health Care, Inc
Fort Collins, Colorado, United States
Rocky Mountain Cancer Centers
Lone Tree, Colorado, United States
Medical Oncology Hematology Consultants
Newark, Delaware, United States
Miami Cancer Institute
Miami, Florida, United States
Hematology Oncology Associates of the Treasure Coast
Port Saint Lucie, Florida, United States
Florida Cancer Specialists - South
Sarasota, Florida, United States
Florida Cancer Specialists - North
St. Petersburg, Florida, United States
Florida Cancer Specialists - East
West Palm Beach, Florida, United States
Piedmont Cancer Institute
Atlanta, Georgia, United States
Piedmont Healthcare
Atlanta, Georgia, United States
Illinois Cancer Specialists
Arlington Heights, Illinois, United States
City of Hope
Chicago, Illinois, United States
OSF Medical Center
Peoria, Illinois, United States
University of Kansas Cancer Center
Fairway, Kansas, United States
Maryland Oncology
Columbia, Maryland, United States
Missouri Cancer Associates
Columbia, Missouri, United States
University of Nebraska Medical Center
Omaha, Nebraska, United States
Comprehensive Cancer Centers
Las Vegas, Nevada, United States
Regional Cancer Care
Belleville, New Jersey, United States
Astera Cancer Care
East Brunswick, New Jersey, United States
NYU Langone Health
New York, New York, United States
Memorial Sloan Kettering Cancer Center
New York, New York, United States
FirstHealth of the Carolinas
Pinehurst, North Carolina, United States
University of Cincinnati Cancer Center
Cincinnati, Ohio, United States
Taylor Cancer Research Center
Maumee, Ohio, United States
Willamette Valley Cancer Institute
Eugene, Oregon, United States
Oregon Health and Science University
Portland, Oregon, United States
Thomas Jefferson University
Philadelphia, Pennsylvania, United States
Prisma Health
Greenville, South Carolina, United States
Avera Cancer Institute Research
Sioux Falls, South Dakota, United States
West Cancer Center
Germantown, Tennessee, United States
Sarah Cannon Research Institute
Nashville, Tennessee, United States
Tennessee Oncology
Nashville, Tennessee, United States
Texas Oncology - West Texas
Abilene, Texas, United States
Texas Oncology - Austin
Austin, Texas, United States
Texas Oncology - San Antonio
San Antonio, Texas, United States
Texas Oncology Gulf Coast
Webster, Texas, United States
Blue Ridge Cancer Care
Blacksburg, Virginia, United States
Virginia Cancer Specialists
Fairfax, Virginia, United States
Virginia Mason Medical Center
Seattle, Washington, United States
University of Washington Fred Hutchinson Cancer Center
Seattle, Washington, United States
Northwest Cancer Specialists
Vancouver, Washington, United States
University of Wisconsin Carbone Cancer Center
Madison, Wisconsin, United States
Nepean Cancer Care Centre
Kingswood, New South Wales, Australia
Calvary Mater Newcastle
Waratah, New South Wales, Australia
Genesiscare
Waratah, New South Wales, Australia
Icon Cancer Centre - Chermside
Chermside, Queensland, Australia
Princess Alexandra Hospital
Woolloongabba, Queensland, Australia
Cancer Research South Australia
Adelaide, South Australia, Australia
Bayside Health
Frankston East, Victoria, Australia
Fiona Stanley Hospital
Murdoch, Western Australia, Australia
One Clinical Research
Nedlands, Western Australia, Australia
Institute of Clinical Oncology
Tbilisi, TB, Georgia
Caucasus Medical Centre
Tbilisi, TB, Georgia
LTD "Multiprofile Clinic Consilium Medulla"
Tbilisi, TB, Georgia
SLK-Kliniken Heilbronn GMBH
Heilbronn, Baden-Wurttemberg, Germany
Pankreasz Betegsegek Intezete, Semmelweis University
Budapest, BU, Hungary
Orszagos Onkologiai Intezet
Budapest, BU, Hungary
University of Debrecen
Debrecen, Hungary
Pratia Poznan
Poznan, Poland
FutureMeds SRL - Galati
Galati, GL, Romania
SC Sigmedical S.R.L
Suceava, Romania
Clinica Universidad de Navarra
Pamplona, Spain
Instituto de Investigacion Sanitaria de Aragon (IIS-A)
Zaragoza, Spain
University Hospitals Coventry and Warwickshire NHS Trust
Coventry, COV, United Kingdom
University College London Hospitals
London, LND, United Kingdom
Imperial College Healthcare NHS
London, LND, United Kingdom
The Christie NHS Foundation
Manchester, MAN, United Kingdom