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A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight
Sponsor: Novo Nordisk A/S
Summary
This clinical study is testing how the study medicine CagriSema helps people living with obesity, with or without type 2 diabetes (T2D), lose weight. The purpose of the study is to find out how safe and effective CagriSema is for body weight loss in these participants. Participants will receive either CagriSema or semaglutide, and which treatment participants receive is decided by chance. CagriSema is a new study medicine being tested, while semaglutide is a medicine that doctors can already prescribe. The study will last for about 83 weeks
Official title: A Clinical Study to Compare Efficacy and Safety of Two Different Doses of CagriSema and Semaglutide in Participants With Obesity With or Without Type 2 Diabetes
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
2500
Start Date
2026-05-21
Completion Date
2028-04-19
Last Updated
2026-09-30
Healthy Volunteers
No
Conditions
Interventions
Cagrisema
Cagrisema (Cagrilintide and Semaglutide) will be administered subcutaneously.
Semaglutide
Semaglutide will be administered subcutaneously.
Locations (303)
Uni of Alabama at Birmingham
Birmingham, Alabama, United States
Cahaba Research
Pelham, Alabama, United States
Elligo Health Research Inc
Gilbert, Arizona, United States
Velocity Clinical Research-Phoenix
Phoenix, Arizona, United States
Arkansas Clinical Research
Little Rock, Arkansas, United States
Woodland Int. Research Group
Little Rock, Arkansas, United States
Headlands Research California, LLC
Escondido, California, United States
Neighborhood Healthcare
Escondido, California, United States
Diabetes & Endocrine Specialists - La Mesa
La Mesa, California, United States
Clinical Trials Research_Sacramento
Lincoln, California, United States
Loma Linda University Faculty Medical Clinics
Loma Linda, California, United States
Pacific Clinical Studies
Los Alamitos, California, United States
Valley Clinical Trials
Northridge, California, United States
Desert Oasis Healthcare
Palm Springs, California, United States
Linda Vista Health Care Ctr
San Diego, California, United States
Velocity Clin Res - Van Nuys
Van Nuys, California, United States
Flourish Research - CA
Walnut Creek, California, United States
University of Colorado Hospital
Aurora, Colorado, United States
TBMR & Alcanza
Clearwater, Florida, United States
Northeast Research Institute
Fleming Island, Florida, United States
Northeast Research Institute
Jacksonville, Florida, United States
Westside Center For Clinical Research
Jacksonville, Florida, United States
Bioclinical Research Alliance
Miami, Florida, United States
New Horizon Research Center
Miami, Florida, United States
South Broward Research LLC
Miramar, Florida, United States
West Orange Endocrinology
Ocoee, Florida, United States
Oviedo Medical Research, LLC
Oviedo, Florida, United States
Clinical Trial Services Corp
Pembroke Pines, Florida, United States
Hope Clin Res & Wellness
Conyers, Georgia, United States
Center for Adv Res & Education
Gainesville, Georgia, United States
Endocrine Research Solutions, Inc
Roswell, Georgia, United States
North Georgia Clinical Research
Woodstock, Georgia, United States
Solaris Clinical Research
Meridian, Idaho, United States
Cedar-Crosse Research Center
Chicago, Illinois, United States
Macoupin Fam Practice Ctr, LLP
Gillespie, Illinois, United States
Clinical Investigation Spec Gurnee
Gurnee, Illinois, United States
Endeavor Health
Skokie, Illinois, United States
Evanston Premier Hlthcr Res
Skokie, Illinois, United States
Iowa Diabetes Research
West Des Moines, Iowa, United States
Alliance for Multispecialty Research
Newton, Kansas, United States
Cotton O'Neil Diab & Endo Ctr
Topeka, Kansas, United States
The Research Group of Lexington LLC
Lexington, Kentucky, United States
Endo and Metabolic Consultants
Rockville, Maryland, United States
Northern Pines Hlth Ctr, PC
Buckley, Michigan, United States
International Diabetes Center
Minneapolis, Minnesota, United States
AES Minneapolis DRS
Richfield, Minnesota, United States
Belzoni Clinical Research
Belzoni, Mississippi, United States
Clinical Research Professionals
Chesterfield, Missouri, United States
Amicis Centers of Clinical Research
St Louis, Missouri, United States
Southgate Medical Group, LLP
West Seneca, New York, United States
PharmQuest Life Sciences LLC
Greensboro, North Carolina, United States
Physician's East Endocrinology
Greenville, North Carolina, United States
Carteret Medical Group
Morehead City, North Carolina, United States
Centricity Rsrch MHCity Multi
Morehead City, North Carolina, United States
Piedmont Healthcare/Research
Statesville, North Carolina, United States
Accellacare Wilmington
Wilmington, North Carolina, United States
Lillestol Research LLC
Fargo, North Dakota, United States
Plains Clinical Research Center, LLC
Fargo, North Dakota, United States
Advanced Medical Research
Maumee, Ohio, United States
Alliance for Multispecialty Research
Norman, Oklahoma, United States
Lynn Institute of Norman
Norman, Oklahoma, United States
Heritage Valley Medical Group
Beaver, Pennsylvania, United States
Hatboro Med Associates
Hatboro, Pennsylvania, United States
Northeast Endocrine Metabolic Associates
Philadelphia, Pennsylvania, United States
Clinical Res Collaborative
Cumberland, Rhode Island, United States
Velocity Clinical Research-Gaffney
Gaffney, South Carolina, United States
Spartanburg Medical Research
Spartanburg, South Carolina, United States
Jackson Clinic
Jackson, Tennessee, United States
Holston Medical Group
Kingsport, Tennessee, United States
CNS Healthcare
Memphis, Tennessee, United States
HealthStar Physicians, PC
Morristown, Tennessee, United States
Clinical Research Associates
Nashville, Tennessee, United States
Amarillo Med Spec LLP
Amarillo, Texas, United States
Texas Diab & Endo, P.A.
Austin, Texas, United States
Velocity Clinical Research Austin
Austin, Texas, United States
Velocity Clin Res, Dallas
Dallas, Texas, United States
North Texas Endocrine Center
Dallas, Texas, United States
Cedar Health Research
Euless, Texas, United States
JCCT- Juno NW Houston
Houston, Texas, United States
The Endocrine Center
Houston, Texas, United States
Medical Colleagues-Texas LLP
Katy, Texas, United States
Sante Clinical Research
Kerrville, Texas, United States
Radiance Clinical Research
Lampasas, Texas, United States
Aeres Clinical Research
Laredo, Texas, United States
DCOL Ctr for Clin Res
Longview, Texas, United States
RGV Endocrine Center
McAllen, Texas, United States
Quality Research Inc
San Antonio, Texas, United States
AES San Antonio
San Antonio, Texas, United States
Northeast Clinical Research of San Antonio
San Antonio, Texas, United States
Consano Clinical Research, LLC
Shavano Park, Texas, United States
Mt Olympus Medical Research, LLC
Sugar Land, Texas, United States
J.Lewis Research Inc
Salt Lake City, Utah, United States
J.Lewis Research Inc
Salt Lake City, Utah, United States
Diabetes & Endo Tx Specialists
Sandy City, Utah, United States
J.Lewis Research Inc
South Jordan, Utah, United States
Health Res of Hampton Roads
Newport News, Virginia, United States
Tidewater Physicians Multispecialty Group
Newport News, Virginia, United States
National Clin Res Inc.
Richmond, Virginia, United States
Prevea Health
Green Bay, Wisconsin, United States
CEMEDIC
CABA, Buenos Aires, Argentina