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A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
Sponsor: Novo Nordisk A/S
Summary
This study is being done to look at the safety and effect of NNC0487-0111 in people with Heart Failure with preserved Ejection Fraction (HFpEF) or Heart Failure with mildly reduced Ejection Fraction (HFmrEF) and excess body weight when compared to placebo. The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have HFpEF or HFmrEF and excess body weight. Participants will get NNC0487-0111 or placebo by injection once a week. Which treatment participants get is decided by chance. NNC0487-0111 is a new medicine that doctors cannot prescribe yet, but it has been tested in people before.
Official title: Efficacy and Safety of NNC0487-0111 Compared to Placebo on Morbidity and Mortality in People With Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
5610
Start Date
2026-05-11
Completion Date
2029-08-15
Last Updated
2026-08-18
Healthy Volunteers
No
Conditions
Interventions
NNC0487-0111
NNC0487-011 will be administered subcutaneously.
Placebo
Placebo (matched to NNC0487-011) will be administered subcutaneously.
Locations (838)
Advanced Cardiovascular, LLC
Alexander City, Alabama, United States
Univ of Alabama Birmingham
Birmingham, Alabama, United States
Eastern Shore Rsrch Inst, LLC
Fairhope, Alabama, United States
Mobile Heart USA Health Cardiology Clinic
Mobile, Alabama, United States
Mercy Gilbert Medical Center
Gilbert, Arizona, United States
Sun City Clinical Research
Glendale, Arizona, United States
Honor Health
Phoenix, Arizona, United States
Arizona Research Center
Phoenix, Arizona, United States
Arkansas Health Group
Little Rock, Arkansas, United States
InvivoCure -2
Alhambra, California, United States
Cardio Research of S. Cal
Beverly Hills, California, United States
Westside Medical Associates Los Angeles
Beverly Hills, California, United States
Scripps Hospital
Chula Vista, California, United States
John Muir Physicians Network
Concord, California, United States
Valley Clinical Trials
Covina, California, United States
Mission Cardiovascular Research Institute
Fremont, California, United States
Amicis Research Center
Granada Hills, California, United States
California Heart Specialist
Huntington Beach, California, United States
Valiance Clinical Research
Huntington Park, California, United States
Joe C.Wen & Fam CTR for Adv Care
Irvine, California, United States
Scripps Memorial Hospital La Jolla
La Jolla, California, United States
UCSD NAFLD Research Center
La Jolla, California, United States
Cardio Innovation & Resch Ctr
Long Beach, California, United States
Pacific Clinical Studies
Los Alamitos, California, United States
VAGrtrLosAngelesHlthcareSystem
Los Angeles, California, United States
Amicis Research Center
Northridge, California, United States
JPJ Research
Northridge, California, United States
Valley Clinical Trials
Northridge, California, United States
Desert Oasis Healthcare
Palm Springs, California, United States
Empire Clin. Research
Pomona, California, United States
G&J Research
San Diego, California, United States
San Diego Veterans Affairs
San Diego, California, United States
Kaiser Permanente Northern California
San Francisco, California, United States
San Francisco V.A. Medical Center
San Francisco, California, United States
Fomat Medical Research
Santa Maria, California, United States
NorthBay Clinical Research
Santa Rosa, California, United States
St. Joseph's Medical Center
Stockton, California, United States
Valiance Clinical Research
Tarzana, California, United States
Care Access Research
Thousand Oaks, California, United States
InvivoCure
Van Nuys, California, United States
Blue Coast Research Center
Vista, California, United States
Interventional Cardiology Medical Group
West Hills, California, United States
Univ of Colorado at Denver
Aurora, Colorado, United States
VA Eastern Colorado Health Care System
Aurora, Colorado, United States
Intermountain Heart & Vascular
Denver, Colorado, United States
Colorado Heart and Vascular PC
Golden, Colorado, United States
The GW Medical Faculty Associates
Washington D.C., District of Columbia, United States
BayCare Health System
Clearwater, Florida, United States
Broward Research Ctr.
Coral Gables, Florida, United States
Nature Coast Clinical Research
Crystal River, Florida, United States
Arrow Clinical Trials
Daytona Beach, Florida, United States
Inpatient Research Clinic LLC
Florida City, Florida, United States
Jacksonville Ctr for Clin Res
Jacksonville, Florida, United States
K2 Medical Research
Maitland, Florida, United States
Total Research Group LLC
Miami, Florida, United States
Infinite Clinical Research
Miami, Florida, United States
Future Life Clinical Trials
Miami, Florida, United States
Broward Research Ctr.
Miami Beach, Florida, United States
Inpatient Research Clinic LLC
Miami Lakes, Florida, United States
Suncoast Clinical Research, Inc.
New Port Richey, Florida, United States
Ocala Cardiovascular Research
Ocala, Florida, United States
Cardiovascular Institute of Orlando
Orlando, Florida, United States
Ormond Beach Clinical Research
Ormond Beach, Florida, United States
DBC Research - Pembroke Pines
Pembroke Pines, Florida, United States
SEC Clinical Research
Pensacola, Florida, United States
Clearwater Cardiovascular Consultants
Safety Harbor, Florida, United States
Intercoastal Medical Group
Sarasota, Florida, United States
St Joseph's Hospital Foundation
Tampa, Florida, United States
Tampa Cardiovascular Interventions and Research
Tampa, Florida, United States
Hope Research Network
Virginia Gardens, Florida, United States
Guardian Research Org LLC
Winter Park, Florida, United States
American Clinical Trials, LLC
Acworth, Georgia, United States
Atlanta Center for Clinical Research_Atlanta
Atlanta, Georgia, United States
East Atlanta Cardiology
Conyers, Georgia, United States
Hope Clin Res & Wellness
Conyers, Georgia, United States
Northeast Georgia Medical Ctr
Gainesville, Georgia, United States
NSC Research, Inc
Johns Creek, Georgia, United States
Peachtree Cardiology
Peachtree, Georgia, United States
Cardiovascular Consultants of South Georgia
Thomasville, Georgia, United States
Atlanta Heart Specialists, LLC
Tucker, Georgia, United States
The Queen's Medical Center
Honolulu, Hawaii, United States
High Desert Heart and Vascular PLLC
Meridian, Idaho, United States
St. Luke's Idaho Cardiology Associates
Meridian, Idaho, United States
Chicago Clinical Research Institute INC
Chicago, Illinois, United States
Univer Of Illinois at Chicago
Chicago, Illinois, United States
Eagle Clinical Research
Chicago, Illinois, United States
Chicago Medical Research LLC
Hazel Crest, Illinois, United States
Chicago Clinical Research Institute INC
Orland Park, Illinois, United States
Methodist Medical Center of Illinois
Peoria, Illinois, United States
Asha Clinical Rsch-Munster, LLC
Hammond, Indiana, United States
Indiana University Health Methodist Hospital
Indianapolis, Indiana, United States
Midwest Cardiovascu Rsrch Foundation
Davenport, Iowa, United States
University OF Iowa
Iowa City, Iowa, United States
West Houston Area Clinical Trial Consultants
Wichita, Kansas, United States
The Research Group of Lexington LLC
Lexington, Kentucky, United States
UofL Health Care Outpatient
Louisville, Kentucky, United States
Research Integrity Global, LLC
Owensboro, Kentucky, United States
Grace Research, LLC
Bossier City, Louisiana, United States
Horizon Research Group of Opelousas, LLC
Eunice, Louisiana, United States
Cardiovascular Institute of the South
Houma, Louisiana, United States