Clinical Research Directory
Browse clinical research sites, groups, and studies.
A Phase 3 Study of INCA033989 Versus Best Available Therapy in Participants With Essential Thrombocythemia
Sponsor: Incyte Corporation
Summary
This study is being conducted to evaluate INCA033989 versus best available therapy in participants with essential thrombocythemia and a CALR mutation previously treated with cytoreductive therapy.
Official title: A Phase 3, Randomized, Open-Label Study of INCA033989 Versus Best Available Therapy in Participants With Essential Thrombocythemia and a CALR Mutation Previously Treated With Cytoreductive Therapy (EXCALIBUR-ET2)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
426
Start Date
2026-09-08
Completion Date
2030-11-01
Last Updated
2026-10-30
Healthy Volunteers
No
Conditions
Interventions
INCA033989
Administered intravenous (IV) in accordance with the protocol-defined requirements.
Best Available Treatment
Best Available Therapy (BAT) will be selected by the investigator.
Locations (193)
University of Alabama At Birmingham Comprehensive Cancer Center
Birmingham, Alabama, United States
Banner Md Anderson Cancer Center
Gilbert, Arizona, United States
City of Hope Medical Center
Duarte, California, United States
Marin Cancer Care
Greenbrae, California, United States
University of California, San Diego-Moores Cancer Center
La Jolla, California, United States
University of California, Los Angeles Medical Center
Los Angeles, California, United States
Stanford Cancer Center
Palo Alto, California, United States
Rocky Mountain Cancer Centers-Lone Tree
Lone Tree, Colorado, United States
Medstar Georgetown Medical Center, Inc
Washington D.C., District of Columbia, United States
Florida Cancer Specialists & Research Institute
Fort Myers, Florida, United States
University of Miami Sylvester Comprehensive Cancer Center
Miami, Florida, United States
Cleveland Clinic
Weston, Florida, United States
Winship Cancer Institute of Emory University
Atlanta, Georgia, United States
Robert H. Lurie Comprehensive Cancer Center of Northwestern University
Chicago, Illinois, United States
University of Chicago
Chicago, Illinois, United States
The University of Kansas Cancer Center
Westwood, Kansas, United States
Our Lady of the Lake Medical Center
Baton Rouge, Louisiana, United States
Johns Hopkins Medicine-the Sidney Kimmel Comprehensive Cancer Center
Baltimore, Maryland, United States
Maryland Oncology Hematology, P.A.
Columbia, Maryland, United States
Massachusetts General Hospital
Boston, Massachusetts, United States
Beth Israel Deaconess Medical Center (Bidmc)
Boston, Massachusetts, United States
University of Massachusetts Medical School
Worcester, Massachusetts, United States
University of Michigan Rogel Cancer Center Adult Bone Marrow Transplant Clinic
Ann Arbor, Michigan, United States
Missouri Cancer Associates
Columbia, Missouri, United States
Washington University School of Medicine
St Louis, Missouri, United States
John Theurer Cancer Center, Hackensack University Medical Center
Hackensack, New Jersey, United States
Icahn School of Medicine At Mount Sinai
New York, New York, United States
Memorial Sloan Kettering Cancer Center
New York, New York, United States
Weill Cornell Medical College - Newyork-Presbyterian Hospita
New York, New York, United States
Strong Memorial Hospital University of Rochester Medical Center
Rochester, New York, United States
Duke University Medical Center
Durham, North Carolina, United States
Cleveland Clinic Taussig Cancer Ctr
Cleveland, Ohio, United States
Willamette Valley Cancer Institute and Research Center
Eugene, Oregon, United States
Oregon Health and Science University
Portland, Oregon, United States
Thomas Jefferson University Sidney Kimmel Medical College
Philadelphia, Pennsylvania, United States
Vanderbilt University Medical Center
Nashville, Tennessee, United States
Baylor Charles A. Sammons Cancer Center
Dallas, Texas, United States
The University of Texas-Md Anderson Cancer Center
Houston, Texas, United States
Ut Health Science Center At San Antonio
San Antonio, Texas, United States
Texas Oncology-Tyler
Tyler, Texas, United States
Huntsman Cancer Institute At University of Utah
Salt Lake City, Utah, United States
Virginia Oncology Associates (Brock Cancer Center)
Norfolk, Virginia, United States
University of Washington - Fred Hutch Cancer Center
Seattle, Washington, United States
Blacktown Cancer & Haematology Centre-Blacktown Hospital
Blacktown, New South Wales, Australia
Gosford Hospital (Gh) - Central Coast Cancer Centre
Gosford, New South Wales, Australia
Liverpool Hospital - South Western Sydney Local Health District
Liverpool, New South Wales, Australia
Sunshine Coast University Hospital
Birtinya, Queensland, Australia
Royal Brisbane and Women'S Hospital
Brisbane, Queensland, Australia
Icon Cancer Centre Adelaide
Kurralta Park, South Australia, Australia
Peter Maccallum Cancer Centre
Melbourne, Victoria, Australia
Box Hill Hospital
Melbourne, Victoria, Australia
Rockingham General Hospital
Cooloongup, Australia
The Canberra Hospital
Garran, Australia
Royal Perth Hospital
Perth, Australia
Lkh - Medizinische Universitaet Graz
Graz, Austria
Landeskrankenhaus (Lkh) Leoben - Standort Leoben
Leoben, Austria
Ordensklinikum Linz Gmbh Elisabethinen
Linz, Austria
Medizinische Universitaet Wien, Akh Wien
Vienna, Austria
Klinikum Wels-Grieskirchen Gmbh
Wels, Austria
Jules Bordet Lnstitute
Anderlecht, Belgium
Centre Hospitalier Universitaire (Chu) Brugmann (Brugmann University Hospital (Uh)) - Victor Horta
Brussels, Belgium
Universitair Ziekenhuis Leuven
Leuven, Belgium
Centre Hospitalier Universitaire de Liege - Sart Tilman
Liège, Belgium
Algemeen Ziekenhuis Deltaaretaie
Roeselare, Belgium
Universite Catholique de Louvain (Ucl) - Cliniques Universitaires Saint-Luc
Woluwe-Saint-Lambert, Belgium
St. Paul'S Hospital (Sph), Providence Health Care, University of British Columbia
Vancouver, British Columbia, Canada
Juravinski Cancer Centre-Hamilton Health Sciences (Hhs)
Hamilton, Ontario, Canada
Queens University, Kingston General Hospital (Kgh), Kingston Health Sciences Centre (Khsc)
Kingston, Ontario, Canada
University Health Network (Uhn) - Princess Margaret Cancer Centre
Toronto, Ontario, Canada
Sir Mortimer B. Davis - Jewish General Hospital
Montreal, Quebec, Canada
McGill University Health Centre - Glen Site, Centre For Innovative Medicine
Montreal, Quebec, Canada
Hotel-Dieu de Levis
Québec, Quebec, Canada
Fakultni Nemocnice Brno
Brno, Czechia
Fakultni Nemocnice Ostrava
Ostrava-poruba, Czechia
Faculty Hospital Kralovske Vinohrady
Prague, Czechia
Vseobecna Fakultni Nemocnice V Praze
Prague, Czechia
Ustav Hematologie A Krevni Transfuze (Uhkt)
Prague, Czechia
Chu D'Amiens-Picardie - Hopital Sud
Amiens, France
Institut Bergonie - Centre Regional de Lutte Contre Le Cancer de Bordeaux Et Sud Ouest
Bordeaux, France
Chu de Brest Hopital de La Cavale Blanche Cic Hematologie
Brest, France
Hospital Henri Mondor
Créteil, France
Hopital Bicetre - Paris Sud (Ap-Hp)
Le Kremlin-Bicêtre, France
Centre Hospitalier Universitaire de Nice,Hopital L Archet
Nice, France
Hospital Saint-Louis - Aphp
Paris, France
Centre Hospitalier Universitaire de Poitiers La Miletrie
Poitiers, France
Institut Claudius Regaud Cancer Comprehensive Center - Iuct Oncopole
Toulouse, France
Israel-Georgian Medical Research Clinic Healthycore
Tbilisi, Georgia
K. Eristavi National Center of Experimental and Clinical Surgery
Tbilisi, Georgia
Medulla - Clinics and Medical Centers
Tbilisi, Georgia
Uniklinik Rwth Aachen Medizinische Klinik Iv
Aachen, Germany
Charite - Universitaetsmedizin Berlin
Berlin, Germany
Bag Onkologische Gemeinschaftspraxis Illmer Jacobasch Wolf Freiberg-Richter Fae Fur Innere Medizi
Dresden, Germany
Universitaetsklinikum Freiburg
Freiburg im Breisgau, Germany
Universitaetsklinikum Halle
Halle, Germany
Universitaetsklinikum Hamburg-Eppendorf
Hamburg, Germany
Medizinische Hochschule Hannover, Hannover Medical School
Hanover, Germany
Universitaetsklinikum Des Saarlandes Und Medizinische Fakultaet Der Universitaet Des Saarlandes
Homburg, Germany
Universitaetsklinikum Jena
Jena, Germany
Universitaetsklinikum Schleswig-Holstein (Uksh) - Campus Luebeck
Lübeck, Germany
Medizinische Fakultaet Mannheim Der Universitaet Heidelberg
Mannheim, Germany