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RECRUITING
NCT07623200
PHASE3

A Phase 3 Study of INCA033989 Versus Best Available Therapy in Participants With Essential Thrombocythemia

Sponsor: Incyte Corporation

View on ClinicalTrials.gov

Summary

This study is being conducted to evaluate INCA033989 versus best available therapy in participants with essential thrombocythemia and a CALR mutation previously treated with cytoreductive therapy.

Official title: A Phase 3, Randomized, Open-Label Study of INCA033989 Versus Best Available Therapy in Participants With Essential Thrombocythemia and a CALR Mutation Previously Treated With Cytoreductive Therapy (EXCALIBUR-ET2)

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

426

Start Date

2026-09-08

Completion Date

2030-11-01

Last Updated

2026-10-30

Healthy Volunteers

No

Interventions

DRUG

INCA033989

Administered intravenous (IV) in accordance with the protocol-defined requirements.

DRUG

Best Available Treatment

Best Available Therapy (BAT) will be selected by the investigator.

Locations (193)

University of Alabama At Birmingham Comprehensive Cancer Center

Birmingham, Alabama, United States

Banner Md Anderson Cancer Center

Gilbert, Arizona, United States

City of Hope Medical Center

Duarte, California, United States

Marin Cancer Care

Greenbrae, California, United States

University of California, San Diego-Moores Cancer Center

La Jolla, California, United States

University of California, Los Angeles Medical Center

Los Angeles, California, United States

Stanford Cancer Center

Palo Alto, California, United States

Rocky Mountain Cancer Centers-Lone Tree

Lone Tree, Colorado, United States

Medstar Georgetown Medical Center, Inc

Washington D.C., District of Columbia, United States

Florida Cancer Specialists & Research Institute

Fort Myers, Florida, United States

University of Miami Sylvester Comprehensive Cancer Center

Miami, Florida, United States

Cleveland Clinic

Weston, Florida, United States

Winship Cancer Institute of Emory University

Atlanta, Georgia, United States

Robert H. Lurie Comprehensive Cancer Center of Northwestern University

Chicago, Illinois, United States

University of Chicago

Chicago, Illinois, United States

The University of Kansas Cancer Center

Westwood, Kansas, United States

Our Lady of the Lake Medical Center

Baton Rouge, Louisiana, United States

Johns Hopkins Medicine-the Sidney Kimmel Comprehensive Cancer Center

Baltimore, Maryland, United States

Maryland Oncology Hematology, P.A.

Columbia, Maryland, United States

Massachusetts General Hospital

Boston, Massachusetts, United States

Beth Israel Deaconess Medical Center (Bidmc)

Boston, Massachusetts, United States

University of Massachusetts Medical School

Worcester, Massachusetts, United States

University of Michigan Rogel Cancer Center Adult Bone Marrow Transplant Clinic

Ann Arbor, Michigan, United States

Missouri Cancer Associates

Columbia, Missouri, United States

Washington University School of Medicine

St Louis, Missouri, United States

John Theurer Cancer Center, Hackensack University Medical Center

Hackensack, New Jersey, United States

Icahn School of Medicine At Mount Sinai

New York, New York, United States

Memorial Sloan Kettering Cancer Center

New York, New York, United States

Weill Cornell Medical College - Newyork-Presbyterian Hospita

New York, New York, United States

Strong Memorial Hospital University of Rochester Medical Center

Rochester, New York, United States

Duke University Medical Center

Durham, North Carolina, United States

Cleveland Clinic Taussig Cancer Ctr

Cleveland, Ohio, United States

Willamette Valley Cancer Institute and Research Center

Eugene, Oregon, United States

Oregon Health and Science University

Portland, Oregon, United States

Thomas Jefferson University Sidney Kimmel Medical College

Philadelphia, Pennsylvania, United States

Vanderbilt University Medical Center

Nashville, Tennessee, United States

Baylor Charles A. Sammons Cancer Center

Dallas, Texas, United States

The University of Texas-Md Anderson Cancer Center

Houston, Texas, United States

Ut Health Science Center At San Antonio

San Antonio, Texas, United States

Texas Oncology-Tyler

Tyler, Texas, United States

Huntsman Cancer Institute At University of Utah

Salt Lake City, Utah, United States

Virginia Oncology Associates (Brock Cancer Center)

Norfolk, Virginia, United States

University of Washington - Fred Hutch Cancer Center

Seattle, Washington, United States

Blacktown Cancer & Haematology Centre-Blacktown Hospital

Blacktown, New South Wales, Australia

Gosford Hospital (Gh) - Central Coast Cancer Centre

Gosford, New South Wales, Australia

Liverpool Hospital - South Western Sydney Local Health District

Liverpool, New South Wales, Australia

Sunshine Coast University Hospital

Birtinya, Queensland, Australia

Royal Brisbane and Women'S Hospital

Brisbane, Queensland, Australia

Icon Cancer Centre Adelaide

Kurralta Park, South Australia, Australia

Peter Maccallum Cancer Centre

Melbourne, Victoria, Australia

Box Hill Hospital

Melbourne, Victoria, Australia

Rockingham General Hospital

Cooloongup, Australia

The Canberra Hospital

Garran, Australia

Royal Perth Hospital

Perth, Australia

Lkh - Medizinische Universitaet Graz

Graz, Austria

Landeskrankenhaus (Lkh) Leoben - Standort Leoben

Leoben, Austria

Ordensklinikum Linz Gmbh Elisabethinen

Linz, Austria

Medizinische Universitaet Wien, Akh Wien

Vienna, Austria

Klinikum Wels-Grieskirchen Gmbh

Wels, Austria

Jules Bordet Lnstitute

Anderlecht, Belgium

Centre Hospitalier Universitaire (Chu) Brugmann (Brugmann University Hospital (Uh)) - Victor Horta

Brussels, Belgium

Universitair Ziekenhuis Leuven

Leuven, Belgium

Centre Hospitalier Universitaire de Liege - Sart Tilman

Liège, Belgium

Algemeen Ziekenhuis Deltaaretaie

Roeselare, Belgium

Universite Catholique de Louvain (Ucl) - Cliniques Universitaires Saint-Luc

Woluwe-Saint-Lambert, Belgium

St. Paul'S Hospital (Sph), Providence Health Care, University of British Columbia

Vancouver, British Columbia, Canada

Juravinski Cancer Centre-Hamilton Health Sciences (Hhs)

Hamilton, Ontario, Canada

Queens University, Kingston General Hospital (Kgh), Kingston Health Sciences Centre (Khsc)

Kingston, Ontario, Canada

University Health Network (Uhn) - Princess Margaret Cancer Centre

Toronto, Ontario, Canada

Sir Mortimer B. Davis - Jewish General Hospital

Montreal, Quebec, Canada

McGill University Health Centre - Glen Site, Centre For Innovative Medicine

Montreal, Quebec, Canada

Hotel-Dieu de Levis

Québec, Quebec, Canada

Fakultni Nemocnice Brno

Brno, Czechia

Fakultni Nemocnice Ostrava

Ostrava-poruba, Czechia

Faculty Hospital Kralovske Vinohrady

Prague, Czechia

Vseobecna Fakultni Nemocnice V Praze

Prague, Czechia

Ustav Hematologie A Krevni Transfuze (Uhkt)

Prague, Czechia

Chu D'Amiens-Picardie - Hopital Sud

Amiens, France

Institut Bergonie - Centre Regional de Lutte Contre Le Cancer de Bordeaux Et Sud Ouest

Bordeaux, France

Chu de Brest Hopital de La Cavale Blanche Cic Hematologie

Brest, France

Hospital Henri Mondor

Créteil, France

Hopital Bicetre - Paris Sud (Ap-Hp)

Le Kremlin-Bicêtre, France

Centre Hospitalier Universitaire de Nice,Hopital L Archet

Nice, France

Hospital Saint-Louis - Aphp

Paris, France

Centre Hospitalier Universitaire de Poitiers La Miletrie

Poitiers, France

Institut Claudius Regaud Cancer Comprehensive Center - Iuct Oncopole

Toulouse, France

Israel-Georgian Medical Research Clinic Healthycore

Tbilisi, Georgia

K. Eristavi National Center of Experimental and Clinical Surgery

Tbilisi, Georgia

Medulla - Clinics and Medical Centers

Tbilisi, Georgia

Uniklinik Rwth Aachen Medizinische Klinik Iv

Aachen, Germany

Charite - Universitaetsmedizin Berlin

Berlin, Germany

Bag Onkologische Gemeinschaftspraxis Illmer Jacobasch Wolf Freiberg-Richter Fae Fur Innere Medizi

Dresden, Germany

Universitaetsklinikum Freiburg

Freiburg im Breisgau, Germany

Universitaetsklinikum Halle

Halle, Germany

Universitaetsklinikum Hamburg-Eppendorf

Hamburg, Germany

Medizinische Hochschule Hannover, Hannover Medical School

Hanover, Germany

Universitaetsklinikum Des Saarlandes Und Medizinische Fakultaet Der Universitaet Des Saarlandes

Homburg, Germany

Universitaetsklinikum Jena

Jena, Germany

Universitaetsklinikum Schleswig-Holstein (Uksh) - Campus Luebeck

Lübeck, Germany

Medizinische Fakultaet Mannheim Der Universitaet Heidelberg

Mannheim, Germany

And 93 more locations on ClinicalTrials.gov