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Long-term Safety and Efficacy of Multiple Long-acting Antibodies Alone and in Combinations for IBD
Sponsor: Spyre Therapeutics, Inc.
Summary
This is a multicenter, long-term extension (LTE) study in participants with ulcerative colitis (UC) from Study SPY123-201 (The SKYLINE-UC study).
Official title: A Study to Evaluate the Long-term Safety and Efficacy of Long-acting Antibodies as Single Agents and in Combinations in Participants With Inflammatory Bowel Disease
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
645
Start Date
2026-06-08
Completion Date
2030-01-03
Last Updated
2026-11-03
Healthy Volunteers
No
Interventions
SPY001
Experimental
SPY002
Experimental
SPY003
Experimental
Locations (98)
Site 023
La Jolla, California, United States
Site 012
Lancaster, California, United States
Site 007
Kissimmee, Florida, United States
Site 035
Marrero, Louisiana, United States
Site 028
Rochester, Minnesota, United States
Site 025
Providence, Rhode Island, United States
Study Site 002
San Antonio, Texas, United States
Site 008
Southlake, Texas, United States
Site 019
Tacoma, Washington, United States
Site 102
Lujan de Cuyo, Mendoza Province, Argentina
Site 103
Rosario, Santa Fe Province, Argentina
Site 208
Concord, New South Wales, Australia
Site 206
South Brisbane, Queensland, Australia
Site 463
Linz, Upper Austria, Austria
Site 461
Salzburg, Austria
Site 473
Leuven, Flemish Brabant, Belgium
Site 471
Ghent, Oost-Vlaanderen, Belgium
Site 126
Passo Fundo, Rio Grande Sul, Brazil
Site 128
Santo André, São Paulo, Brazil
Site 153
Osorno, Los Lagos Region, Chile
Site 152
Santiago, Santiago Metropolitan, Chile
Site 531
Brno, Czechia
Site 584
Kutaisi, Georgia
Site 589
Marneuli, Georgia
Site 581
Tbilisi, Georgia
Site 588
Tbilisi, Georgia
Site 583
Tbilisi, Georgia
Site 586
Tbilisi, Georgia
Site 582
Tbilisi, Georgia
Site 587
Tbilisi, Georgia
Site 603
Ulm, Germany
Site 634
Athens, Greece
Site 654
Békéscsaba, Hungary
Site 651
Budapest, Hungary
Site 652
Székesfehérvár, Hungary
Site 673
Legnano, Milan, Italy
Site 672
Negrar, Verona, Italy
Site 424
Amman, Jordan
Site 421
Amman, Jordan
Site 422
Irbid, Jordan
Site 423
Irbid, Jordan
Site 174
Saltillo, Coahuila, Mexico
Site 175
Celaya, Guanajuato, Mexico
Site 173
Tlajomulco de Zúñiga, Jalisco, Mexico
Site 711
Chisinau, Moldova
Site 715
Chisinau, Moldova
Site 712
Chisinau, Moldova
Site 753
Bydgoszcz, Poland
Site 732
Bydgoszcz, Poland
Site 748
Krakow, Poland
Site 750
Kłodzko, Poland
Site 746
Lodz, Poland
Site 743
Opole, Poland
Site 740
Poznan, Poland
Site 736
Rzeszów, Poland
Site 744
Sopot, Poland
Site 737
Szczecin, Poland
Site 733
Szczecin, Poland
Site 752
Tychy, Poland
Site 754
Warsaw, Poland
Site 731
Warsaw, Poland
Site 738
Wroclaw, Poland
Site 734
Wroclaw, Poland
Site 747
Wroclaw, Poland
Site 742
Wroclaw, Poland
Site 781
Bucharest, Romania
Site 788
Timișoara, Romania
Site 802
Belgrade, Serbia
Site 803
Belgrade, Serbia
Site 807
Belgrade, Serbia
Site 801
Zrenjanin, Serbia
Site 823
Bratislava, Slovakia
Site 822
Košice, Slovakia
Site 824
Prešov, Slovakia
Site 353
Wŏnju, Gangwon-do, South Korea
Site 357
Busan, South Korea
Site 354
Daegu, South Korea
Site 361
Daegu, South Korea
Site 355
Daejeon, South Korea
Site 356
Seoul, South Korea
Site 362
Seoul, South Korea
Site 360
Seoul, South Korea
Site 394
Changhua, Taiwan
Site 392
Chiayi City, Taiwan
Site 395
Kaohsiung City, Taiwan
Site 396
Taichung, Taiwan
Site 391
Taipei, Taiwan
Site 906
Ivano-Frankivsk, Ukraine
Site 902
Kyiv, Ukraine
Site 904
Kyiv, Ukraine
Site 913
Kyiv, Ukraine
Site 911
Kyiv, Ukraine
Site 903
Kyiv, Ukraine
Site 901
Lutsk, Ukraine
Site 909
Lviv, Ukraine
Site 914
Poltava, Ukraine
Site 908
Vinnytsia, Ukraine
Site 907
Vinnytsia, Ukraine