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A Phase IIb Study to Evaluate AZD8965 in Participants With IPF.
Sponsor: AstraZeneca
Summary
This Phase IIb study aims to evaluate the efficacy, safety, and tolerability of 3 doses of AZD8965 treatment compared to placebo in participants with IPF, including those on antifibrotic therapy (nintedanib, pirfenidone, nerandomilast), either alone or in combination, or in those not on antifibrotic therapy.
Official title: A Phase IIb Study to Evaluate the Efficacy, Safety, and Tolerability of AZD8965 in Participants With Idiopathic Pulmonary Fibrosis (IPF) (ARGiNAUT)
Key Details
Gender
All
Age Range
40 Years - Any
Study Type
INTERVENTIONAL
Enrollment
359
Start Date
2026-06-11
Completion Date
2028-09-18
Last Updated
2026-10-29
Healthy Volunteers
No
Conditions
Interventions
Placebo for AZD8965
Placebo for AZD8965
AZD8965 low dose
AZD8965 low dose
AZD8965 medium dose
AZD8965 medium dose
AZD8965 high dose
AZD8965 high dose
Locations (198)
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Birmingham, Alabama, United States
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Phoenix, Arizona, United States
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Phoenix, Arizona, United States
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Loma Linda, California, United States
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Los Angeles, California, United States
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Newport Beach, California, United States
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Sacramento, California, United States
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Stanford, California, United States
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Aurora, Colorado, United States
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Denver, Colorado, United States
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Ocala, Florida, United States
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Weston, Florida, United States
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Atlanta, Georgia, United States
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Boise, Idaho, United States
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Champaign, Illinois, United States
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Chicago, Illinois, United States
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Kansas City, Kansas, United States
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Lexington, Kentucky, United States
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Baltimore, Maryland, United States
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Boston, Massachusetts, United States
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Ann Arbor, Michigan, United States
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Detroit, Michigan, United States
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New York, New York, United States
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New York, New York, United States
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Greensboro, North Carolina, United States
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Cincinnati, Ohio, United States
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Oklahoma City, Oklahoma, United States
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Fountain Hill, Pennsylvania, United States
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Philadelphia, Pennsylvania, United States
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Philadelphia, Pennsylvania, United States
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Charleston, South Carolina, United States
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Dallas, Texas, United States
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El Paso, Texas, United States
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Houston, Texas, United States
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Burlington, Vermont, United States
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Richmond, Virginia, United States
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Alberdi, Argentina
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Buenos Aires, Argentina
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Ciudad de Buenos Aires, Argentina
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Florida, Argentina
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Rosario, Argentina
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San Fernando, Argentina
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Camperdown, Australia
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Port Macquarie, Australia
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Wollongong, Australia
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Haskovo, Bulgaria
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Plovdiv, Bulgaria
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Rousse, Bulgaria
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Rousse, Bulgaria
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Sofia, Bulgaria
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Sofia, Bulgaria
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Sofia, Bulgaria
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Sofia, Bulgaria
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Sherwood Park, Alberta, Canada
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Vancouver, British Columbia, Canada
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Ajax, Ontario, Canada
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Burlington, Ontario, Canada
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Kingston, Ontario, Canada
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North York, Ontario, Canada
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Saint-Charles-Borromée, Quebec, Canada
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Sherbrooke, Quebec, Canada
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Providencia, Chile
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Santiago, Chile
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Talca, Chile
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Viña del Mar, Chile
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Viña del Mar, Chile
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Beijing, China
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Beijing, China
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Beijing, China
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Changchun, China
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Changsha, China
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Chengdu, China
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Chengdu, China
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Guangzhou, China
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Lanzhou, China
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Nanchang, China
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Nanjing, China
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Shanghai, China
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Shenyang, China
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Wuhan, China
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Xuzhou, China
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Zhengzhou, China
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Aarhus, Denmark
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Copenhagen, Denmark
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Hellerup, Denmark
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Odense C, Denmark
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Angers, France
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Brest, France
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Bron, France
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Montpellier, France
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Nice, France
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Paris, France
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Rennes, France
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Tours, France
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Bonn, Germany
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Coswig, Germany
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Essen, Germany
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Freiburg im Breisgau, Germany
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Fulda, Germany
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Giessen, Germany