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A Phase III Study to Investigate the Efficacy and Safety of the Combination of Elecoglipron and Dapagliflozin in Adults With Type 2 Diabetes Mellitus
Sponsor: AstraZeneca
Summary
The purpose of this study is to evaluate the efficacy, safety, and tolerability of elecoglipron and dapagliflozin in combination, compared with elecoglipron alone and dapagliflozin alone, in adults with type 2 diabetes mellitus (T2DM) inadequately managed with lifestyle management alone or treated with other background glucose-lowering medication.
Official title: A Randomized, Double-blind, Parallel-group Phase III Study to Evaluate the Efficacy, Safety, and Tolerability of Elecoglipron and Dapagliflozin in Combination, Compared With Elecoglipron Alone and Dapagliflozin Alone, in Adults With Type 2 Diabetes Mellitus (Eluminate-5)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
2000
Start Date
2026-07-06
Completion Date
2028-07-05
Last Updated
2026-10-30
Healthy Volunteers
No
Conditions
Interventions
Elecoglipron
Elecoglipron is administered orally once daily.
Dapagliflozin
Dapagliflozin administered orally once daily.
Elecoglipron-matched placebo
A placebo matching elecoglipron administered orally once daily.
Dapagliflozin-matched placebo
A placebo matching dapagliflozin administered orally once daily.
Locations (303)
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Huntsville, Alabama, United States
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Mobile, Alabama, United States
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Sheffield, Alabama, United States
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Little Rock, Arkansas, United States
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Bakersfield, California, United States
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Los Angeles, California, United States
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Ontario, California, United States
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Lake City, Florida, United States
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Lakeland, Florida, United States
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Atlanta, Georgia, United States
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Chicago, Illinois, United States
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Skokie, Illinois, United States
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Evansville, Indiana, United States
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Sioux City, Iowa, United States
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Zachary, Louisiana, United States
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Annapolis, Maryland, United States
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Lutherville-Timonium, Maryland, United States
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Oxon Hill, Maryland, United States
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Boston, Massachusetts, United States
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Boston, Massachusetts, United States
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Troy, Michigan, United States
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Ridgeland, Mississippi, United States
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Elkhorn, Nebraska, United States
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Toms River, New Jersey, United States
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Albuquerque, New Mexico, United States
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Brooklyn, New York, United States
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Rosedale, New York, United States
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Raleigh, North Carolina, United States
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Beachwood, Ohio, United States
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Maumee, Ohio, United States
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Norman, Oklahoma, United States
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Philadelphia, Pennsylvania, United States
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Kingsport, Tennessee, United States
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Nashville, Tennessee, United States
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Dallas, Texas, United States
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McKinney, Texas, United States
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Paris, Texas, United States
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San Antonio, Texas, United States
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Webster, Texas, United States
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Layton, Utah, United States
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South Jordan, Utah, United States
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Newport News, Virginia, United States
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Vienna, Virginia, United States
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Redmond, Washington, United States
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Kingwood, West Virginia, United States
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Buenos Aires, Argentina
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Buenos Aires, Argentina
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Buenos Aires, Argentina
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Caba, Argentina
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Ciudad de Buenos Aires, Argentina
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Mar del Plata, Argentina
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Rosario, Argentina
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San Nicolás, Argentina
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San Vicente, Argentina
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Barretos, Brazil
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Brasília, Brazil
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Campinas, Brazil
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Curitiba, Brazil
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Fortaleza, Brazil
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Natal, Brazil
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Porto Alegre, Brazil
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Rio de Janeiro, Brazil
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São José dos Campos, Brazil
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São Paulo, Brazil
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São Paulo, Brazil
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Baotou, China
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Beijing, China
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Beijing, China
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Beijing, China
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Changde, China
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Changsha, China
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Changzhou, China
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Chengdu, China
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Chengdu, China
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Chenzhou, China
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Chifeng, China
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Hangzhou, China
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Hefei, China
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Huai'an, China
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Jinan, China
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Jincheng, China
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Jining, China
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Jinzhou Shi, China
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Kaifeng, China
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Langfang, China
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Liangyugang, China
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Luoyang, China
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Meihekou, China
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Nanjing, China
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Nantong, China
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Nanyang, China
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Pinggu, China
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Pingxiang, China
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Sanya, China
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Shanghai, China
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Shanghai, China
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Shantou, China
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Shenyang, China
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Shenyang, China
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Shijiazhuang, China