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A Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes Mellitus
Sponsor: AstraZeneca
Summary
The purpose of this study is to evaluate the efficacy, safety, and tolerability of elecoglipron compared with oral semaglutide in adults with T2DM and increased cardiovascular risk that is inadequately managed alone or on stable treatment with other background glucose-lowering medication(s).
Official title: A Randomized, Open-label, Parallel-group Phase III Study to Evaluate the Efficacy, Safety, and Tolerability of Elecoglipron Compared With Oral Semaglutide in Adults With Type 2 Diabetes Mellitus (Eluminate-2)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
1200
Start Date
2026-07-06
Completion Date
2028-05-23
Last Updated
2026-10-22
Healthy Volunteers
No
Conditions
Interventions
Elecoglipron
Elecoglipron is administered orally once daily.
Semaglutide
Semaglutide is administered orally once daily.
Locations (210)
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Birmingham, Alabama, United States
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Mesa, Arizona, United States
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Phoenix, Arizona, United States
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Tempe, Arizona, United States
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Covina, California, United States
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Encinitas, California, United States
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Garden Grove, California, United States
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Loma Linda, California, United States
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Long Beach, California, United States
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Pomona, California, United States
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Sacramento, California, United States
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Bridgeport, Connecticut, United States
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Crystal River, Florida, United States
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Hollywood, Florida, United States
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Jacksonville, Florida, United States
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Lake City, Florida, United States
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Leesburg, Florida, United States
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Orlando, Florida, United States
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Lilburn, Georgia, United States
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Idaho Falls, Idaho, United States
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Melrose Park, Illinois, United States
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Evansville, Indiana, United States
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Ames, Iowa, United States
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Wichita, Kansas, United States
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Bowling Green, Kentucky, United States
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Rockville, Maryland, United States
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Rockville, Maryland, United States
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Southfield, Michigan, United States
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Minneapolis, Minnesota, United States
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Jefferson City, Missouri, United States
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Kansas City, Missouri, United States
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Omaha, Nebraska, United States
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Henderson, Nevada, United States
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Las Vegas, Nevada, United States
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Albuquerque, New Mexico, United States
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Durham, North Carolina, United States
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Morehead City, North Carolina, United States
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Raleigh, North Carolina, United States
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Statesville, North Carolina, United States
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Wilmington, North Carolina, United States
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Columbus, Ohio, United States
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Oklahoma City, Oklahoma, United States
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Feasterville-Trevose, Pennsylvania, United States
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Philadelphia, Pennsylvania, United States
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Myrtle Beach, South Carolina, United States
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North Charleston, South Carolina, United States
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Memphis, Tennessee, United States
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Morristown, Tennessee, United States
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Dallas, Texas, United States
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Houston, Texas, United States
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Houston, Texas, United States
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Houston, Texas, United States
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Katy, Texas, United States
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San Antonio, Texas, United States
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San Antonio, Texas, United States
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Sugar Land, Texas, United States
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Weslaco, Texas, United States
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Bountiful, Utah, United States
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Salt Lake City, Utah, United States
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Falls Church, Virginia, United States
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Norfolk, Virginia, United States
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Renton, Washington, United States
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Seattle, Washington, United States
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Seattle, Washington, United States
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Morgantown, West Virginia, United States
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Buenos Aires, Argentina
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Buenos Aires, Argentina
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Caba, Argentina
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Ciudad de Buenos Aires, Argentina
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Rosario, Argentina
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San Nicolás, Argentina
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San Vicente, Argentina
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Botany, Australia
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East Toowoomba, Australia
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Fitzroy, Australia
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Heidelberg Heights, Australia
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Kingswood, Australia
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Melbourne, Australia
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Parkville, Australia
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Penrith, Australia
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St Leonards, Australia
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Brasília, Brazil
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Campinas, Brazil
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Curitiba, Brazil
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Natal, Brazil
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Porto Alegre, Brazil
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São José dos Campos, Brazil
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São Paulo, Brazil
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Plovdiv, Bulgaria
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Sofia, Bulgaria
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Sofia, Bulgaria
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Sofia, Bulgaria
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Yambol, Bulgaria
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Vancouver, British Columbia, Canada
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Guelph, Ontario, Canada
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Sarnia, Ontario, Canada
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Scarborough Village, Ontario, Canada
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Stouffville, Ontario, Canada
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Toronto, Ontario, Canada
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Toronto, Ontario, Canada