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A Study To Assess the Safety, Tolerability, and Efficacy of Imzokitug in Combination With Pumitamig and Platinum-Doublet Chemotherapy (PDCT) Versus Pumitamig and PDCT as First-line Treatment for Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
Sponsor: Bristol-Myers Squibb
Summary
The purpose of this study is to assess the safety, tolerability, and efficacy of Imzokitug in combination with Pumitamig and Platinum-Doublet Chemotherapy (PDCT) versus Pumitamig and PDCT as first-line treatment for participants with Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
Official title: A Phase 2, Randomized, Open-label, Study Assessing the Safety, Tolerability and Efficacy of Imzokitug in Combination With Pumitamig and Platinum-Doublet Chemotherapy (PDCT) Versus Pumitamig and PDCT as First-line Treatment for Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
160
Start Date
2026-09-10
Completion Date
2030-09-15
Last Updated
2026-10-23
Healthy Volunteers
No
Conditions
Interventions
Pumitamig
Specified dose on specified days
Imzokitug
Specified dose on specified days
Pemetrexed
Specified dose on specified days
Cisplatin
Specified dose on specified days
Carboplatin
Specified dose on specified days
Paclitaxel
Specified dose on specified days
Locations (74)
Local Institution - 0183
Washington D.C., District of Columbia, United States
University Cancer & Blood Center, LLC
Athens, Georgia, United States
Baptist Health Lexington
Lexington, Kentucky, United States
Baptist Health Hamburg
Lexington, Kentucky, United States
Local Institution - 0123
Baltimore, Maryland, United States
Hattiesburg Clinic
Hattiesburg, Mississippi, United States
Nebraska Cancer Specialists
Grand Island, Nebraska, United States
Oncology Hematology West PC
Omaha, Nebraska, United States
Local Institution - 0080
New York, New York, United States
Local Institution - 0176
Columbus, Ohio, United States
Local Institution - 0095
Houston, Texas, United States
Local Institution - 0135
Madison, Wisconsin, United States
Sanatorio Parque Rosario
Rosario, Santa Fe Province, Argentina
Instituto Medico Especializado Alexander Fleming
Buenos Aires, Argentina
Clinica Viedma S.A.
Viedma, Argentina
Gosford Hospital
Gosford, New South Wales, Australia
Local Institution - 0134
Westmead, New South Wales, Australia
Local Institution - 0167
Greenslopes, Queensland, Australia
Local Institution - 0100
Heidelberg, Victoria, Australia
St. John of God Murdoch Hospital
Perth, Western Australia, Australia
Local Institution - 0003
Natal/RN, Rio Grande do Norte, Brazil
Local Institution - 0006
Porto Alegre, Rio Grande do Sul, Brazil
Local Institution - 0005
Barretos, São Paulo, Brazil
Local Institution - 0001
São Paulo, Brazil
Orlandi Oncologia
Santiago, Santiago Metropolitan, Chile
Bradfordhill
Santiago, Santiago Metropolitan, Chile
Oncocentro Apys
Viña del Mar, Valparaiso, Chile
Local Institution - 0038
Beijing, Beijing Municipality, China
Local Institution - 0138
Fuzhou, Fujian, China
Local Institution - 0050
Wuhan, Hubei, China
Local Institution - 0147
Nanjing, Jiangsu, China
Local Institution - 0140
Shanghai, Shanghai Municipality, China
Local Institution - 0169
Shanghai, Shanghai Municipality, China
Local Institution - 0144
Chengdu, Sichuan, China
Local Institution - 0137
Hangzhou, Zhejiang, China
Local Institution - 0131
Nice, Alpes-Maritimes, France
Hôpital Arnaud de Villeneuve - CHU Montpellier
Montpellier, Hérault, France
Local Institution - 0087
Montpellier, Languedoc-Roussillon, France
Local Institution - 0119
Villejuif, Val-de-Marne, France
Local Institution - 0047
Grenoble, France
Assistance Publique Hôpitaux de Marseille - Hôpital Nord
Marseille, France
Hopitaux Universitaires Paris Centre-Hopital Cochin
Paris, France
Local Institution - 0085
Saint-Herblain, France
Local Institution - 0019
Paris, Île-de-France Region, France
Robert Bosch Krankenhaus
Stuttgart, Baden-Wurttemberg, Germany
Local Institution - 0156
Marburg, Hesse, Germany
Local Institution - 0152
Homburg, Saarland, Germany
Klinikum Köln-Merheim
Cologne, Germany
Christliches Klinikum Halle (Saale) GmbH
Halle, Germany
Universitatsklinikum Frankfurt
Hessen, Germany
Local Institution - 0148
Bergamo, BG, Italy
Humanitas Istituto Clinico Catanese
Misterbianco, Catania, Italy
Local Institution - 0043
Bari, Italy
Local Institution - 0159
Milan, Italy
Local Institution - 0014
Ravenna, Italy
Local Institution - 0011
Rozzano (MI), Italy
Amethyst Radiotherapy Center-Oncologie Medicala
Florești, Cluj, Romania
Institutul Oncologic "Prof. Dr. Alexandru Trestioreanu" Bucuresti (IOB)
Bucharest, Romania
Institutul Oncologic Cluj
Cluj-Napoca, Romania
Centrul de Oncologie Sf. Nectarie SRL
Craiova, Romania
Victoria Hospital (Centrul de oncologie Euroclinic SRL) (Centrul De Oncologie Medicala) (Euroclinic Onchology Center)
Iași, Romania
Institutul Regional de Oncologie Iasi
Iași, Romania
Oncohelp
Timisoara, Timis, Romania
Local Institution - 0132
Badalona, Barcelona, Spain
Local Institution - 0162
Seville, Seville, Spain
Hospital Universitari Vall D'Hebron
Barcelona, Spain
Hospital de la Santa Creu i Sant Pau
Barcelona, Spain
Local Institution - 0163
Barcelona, Spain
Local Institution - 0041
Madrid, Spain
Local Institution - 0010
Majadahonda, Spain
Hospital Carlos Haya De Malaga
Málaga, Spain
Local Institution - 0182
Birmingham, BIR, United Kingdom
Local Institution - 0035
London, Greater London, United Kingdom
The Royal Surrey County Hospital NHS Foundation Trust
Guildford, United Kingdom