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Study of Izalontamab Brengitecan (BMS-986507) in Combination With Osimertinib Versus Osimertinib Monotherapy or Osimertinib in Combination With Platinum-based Chemotherapy for EGFRmt Non-small Cell Lung Cancer (IZABRIGHT-Lung02)
Sponsor: Bristol-Myers Squibb
Summary
The purpose of this study is to evaluate izalontamab brengitecan (iza-bren) combined with osimertinib in participants with previously untreated, locally advanced or metastatic EGFR-mutant NSCLC, compared to osimertinib alone or osimertinib combined with platinum-based chemotherapy
Official title: A Phase III, Randomized, Open-label Study of Izalontamab Brengitecan (BMS-986507) in Combination With Osimertinib Versus Osimertinib Monotherapy or Osimertinib in Combination With Platinum-based Chemotherapy as First-Line Therapy in Patients With EGFR-Mutant Locally Advanced or Metastatic Non-small Cell Lung Cancer
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
850
Start Date
2026-09-08
Completion Date
2031-12-30
Last Updated
2026-10-26
Healthy Volunteers
No
Conditions
Interventions
Iza-bren
Specified dose on specified days
Osimertinib
Specified dose on days
Pemetrexed
Specified dose on specified days
Carboplatin
Specified dose on specified days
Cisplatin
Specified dose on specified days
Locations (204)
Local Institution - 0212
Beverly Hills, California, United States
Local Institution - 0504
Fullerton, California, United States
Local Institution - 0357
La Jolla, California, United States
Rocky Mountain Cancer Centers
Boulder, Colorado, United States
Local Institution - 0527
Fort Myers, Florida, United States
Local Institution - 0366
Orlando, Florida, United States
Cancer Care Centers of Brevard - Rockledge
Palm Bay, Florida, United States
Local Institution - 0526
St. Petersburg, Florida, United States
Local Institution - 0524
West Palm Beach, Florida, United States
Local Institution - 0185
Chicago, Illinois, United States
Local Institution - 0207
Ottawa, Illinois, United States
Local Institution - 0503
Baltimore, Maryland, United States
Local Institution - 0537
Baltimore, Maryland, United States
Local Institution - 0523
Silver Spring, Maryland, United States
Local Institution - 0521
Edina, Minnesota, United States
Local Institution - 0364
Saint Paul, Minnesota, United States
Local Institution - 0403
St Louis, Missouri, United States
Local Institution - 0402
Omaha, Nebraska, United States
Local Institution - 0290
Lebanon, New Hampshire, United States
Local Institution - 0183
New Brunswick, New Jersey, United States
Local Institution - 0153
New York, New York, United States
Local Institution - 0157
The Bronx, New York, United States
Local Institution - 0385
Charlotte, North Carolina, United States
Local Institution - 0438
Sandusky, Ohio, United States
Local Institution - 0404
Portland, Oregon, United States
Local Institution - 0487
Easton, Pennsylvania, United States
Local Institution - 0200
Sioux Falls, South Dakota, United States
Local Institution - 0199
Memphis, Tennessee, United States
Texas Oncology
Beaumont, Texas, United States
Local Institution - 0525
Dallas, Texas, United States
Texas Oncology - San Antonio
San Antonio, Texas, United States
Local Institution - 0411
Salt Lake City, Utah, United States
Local Institution - 0165
Fairfax, Virginia, United States
Local Institution - 0530
Fairfax, Virginia, United States
Shenandoah Oncology, P.C. (Shenandoah Oncology Associates, P.C.)
Winchester, Virginia, United States
Local Institution - 0283
Seattle, Washington, United States
Local Institution - 0502
Morgantown, West Virginia, United States
Local Institution - 0077
Mar del Plata, Buenos Aires, Argentina
Local Institution - 0514
Río Cuarto, Córdoba Province, Argentina
Local Institution - 0086
Buenos Aires, Argentina
Local Institution - 0432
Buenos Aires, Argentina
Local Institution - 0085
Buenos Aires, Argentina
Local Institution - 0078
Buenos Aires, Argentina
Local Institution - 0151
Buenos Aires, Argentina
Local Institution - 0424
Camperdown, New South Wales, Australia
Local Institution - 0439
Westmead, New South Wales, Australia
Local Institution - 0511
Greenslopes, Queensland, Australia
Local Institution - 0492
Adelaide, South Australia, Australia
Local Institution - 0447
Clayton, Victoria, Australia
Local Institution - 0437
Murdoch, Western Australia, Australia
Local Institution - 0253
Vitória, Espírito Santo, Brazil
Local Institution - 0291
Salvador, Estado de Bahia, Brazil
Local Institution - 0247
Ijuí, Rio Grande do Sul, Brazil
Local Institution - 0252
Florianópolis, Santa Catarina, Brazil
Local Institution - 0244
Barretos, São Paulo, Brazil
Local Institution - 0249
Campinas, São Paulo, Brazil
Local Institution - 0261
Sorocaba, São Paulo, Brazil
Local Institution - 0255
Rio de Janeiro, Brazil
Local Institution - 0259
São Paulo, Brazil
Local Institution - 0059
Edmonton, Alberta, Canada
Local Institution - 0056
Vancouver, British Columbia, Canada
Jewish General Hospital
Montreal, Quebec, Canada
Local Institution - 0057
Montreal, Quebec, Canada
Local Institution - 0040
Regina, Saskatchewan, Canada
Local Institution - 0517
Beijing, Beijing Municipality, China
Local Institution - 0458
Beijing, Beijing Municipality, China
Local Institution - 0535
Chongqing, Chongqing Municipality, China
Local Institution - 0470
Chongqing, Chongqing Municipality, China
Local Institution - 0493
Fuzhou, Fujian, China
Local Institution - 0457
Fuzhou, Fujian, China
Local Institution - 0326
Dongguan Shi, Guangdong, China
Local Institution - 0331
Guangzhou, Guangdong, China
Local Institution - 0512
Jiangmen, Guangdong, China
Local Institution - 0478
Zhongshan, Guangdong, China
Local Institution - 0321
Guilin, Guangxi, China
Local Institution - 0328
Nanning, Guangxi, China
Local Institution - 0505
Guiyang, Guizhou, China
Local Institution - 0330
Haikou, Hainan, China
Local Institution - 0322
Shijiazhuang, Hebei, China
Local Institution - 0343
Harbin, Heilongjiang, China
Local Institution - 0298
Anyang, Henan, China
Local Institution - 0341
Weihui Shi, Henan, China
Local Institution - 0480
Zhengzhou, Henan, China
Local Institution - 0423
Zhengzhou, Henan, China
Local Institution - 0483
Jingzhou, Hubei, China
Local Institution - 0450
Wuhan, Hubei, China
Local Institution - 0482
Changsha, Hunan, China
Local Institution - 0467
Changsha, Hunan, China
Local Institution - 0536
Changsha, Hunan, China
Local Institution - 0306
Changsha Shi, Hunan, China
Local Institution - 0531
Lianyungang, Jiangsu, China
Local Institution - 0347
Nanjing, Jiangsu, China
Local Institution - 0332
Shenyang, Liaoning, China
Local Institution - 0464
Xi'an, Shaanxi, China
Local Institution - 0479
Binzhou, Shandong, China
Local Institution - 0455
Jinan, Shandong, China
Local Institution - 0413
Linyi, Shandong, China
Local Institution - 0469
Weifang Shi, Shandong, China
Local Institution - 0319
Shanghai Shi, Shanghai Municipality, China
Local Institution - 0316
Taiyuan, Shanxi, China