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Relapse Prevention Trial Evaluating KarXT Treatment in Schizophrenia
Sponsor: Karuna Therapeutics, Inc., a Bristol Myers Squibb company
Summary
The purpose of the study is to evaluate the relapse prevention of KarXT in the treatment of participants with Schizophrenia
Official title: A Phase 3 Double-blind, Placebo-controlled Randomized Withdrawal Maintenance Trial of KarXT Treatment in Participants With Schizophrenia
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
472
Start Date
2026-08-20
Completion Date
2029-03-03
Last Updated
2026-10-30
Healthy Volunteers
No
Conditions
Interventions
Xanomeline/Trospium Chloride
Specified dose on specified days
Placebo
Specified dose on specified days
Locations (54)
Pillar Clinical Research - Bentonville
Bentonville, Arkansas, United States
Pillar Clinical Research- Little Rock
Little Rock, Arkansas, United States
Local Institution - 0021
Little Rock, Arkansas, United States
Local Institution - 0153
Rogers, Arkansas, United States
Local Institution - 0190
Anaheim, California, United States
Clinical Innovations, Inc. dba CITrials
Bellflower, California, United States
Local Institution - 0032
Culver City, California, United States
Collaborative Neuroscience Research, LLC
Garden Grove, California, United States
Local Institution - 0068
La Habra, California, United States
Local Institution - 0128
Lemon Grove, California, United States
Local Institution - 0187
Montclair, California, United States
NRC Research Institute
Orange, California, United States
Local Institution - 0030
Pico Rivera, California, United States
Local Institution - 0185
Redlands, California, United States
Local Institution - 0186
Riverside, California, United States
Local Institution - 0193
Torrance, California, United States
Health Synergy Clinical Research
Boynton Beach, Florida, United States
Research Centers of America ( Hollywood )
Hollywood, Florida, United States
Local Institution - 0075
Miami, Florida, United States
Local Institution - 0054
Miami Lakes, Florida, United States
Local Institution - 0134
Miami Springs, Florida, United States
Local Institution - 0195
Oakland Park, Florida, United States
Atlanta Center for Medical Research
Atlanta, Georgia, United States
Local Institution - 0070
Sandy Springs, Georgia, United States
Local Institution - 0189
Savannah, Georgia, United States
Local Institution - 0067
Chicago, Illinois, United States
Pillar Clinical Research -Chicago
Chicago, Illinois, United States
Local Institution - 0192
Gaithersburg, Maryland, United States
Local Institution - 0183
Cincinnati, Ohio, United States
Local Institution - 0047
Oklahoma City, Oklahoma, United States
Local Institution - 0049
Austin, Texas, United States
Pillar Clinical Research - Richardson
Richardson, Texas, United States
Local Institution - 0175
Río Cuarto, Córdoba Province, Argentina
Local Institution - 0143
Buenos Aires, Argentina
Local Institution - 0002
Córdoba, Argentina
Local Institution - 0197
Córdoba, Argentina
Clinica El Jardin
Santiago del Estero, Argentina
Local Institution - 0191
Novi Iskar, Bulgaria
Local Institution - 0162
Brno, Czechia
Local Institution - 0014
Klecany, Czechia
Local Institution - 0123
Warsaw, Masovian Voivodeship, Poland
Local Institution - 0122
Bialystok, Podlaskie Voivodeship, Poland
Local Institution - 0001
Poznan, Poland
Local Institution - 0104
Brașov, Brăila County, Romania
Local Institution - 0103
Bucharest, Bucharest, Romania
Local Institution - 0105
Bucharest, Bucharest, Romania
Local Institution - 0107
Bucharest, Bucharest, Romania
Local Institution - 0110
Bucharest, Bucharest, Romania
Local Institution - 0174
Bucharest, Romania
Local Institution - 0106
Bucharest, Romania
Local Institution - 0109
Bucharest, Romania
Local Institution - 0112
Barcelona, Barcelona [Barcelona], Spain
Local Institution - 0167
Valladolid, Spain
Local Institution - 0181
Zamora, Spain