Clinical Research Directory

Traditional Chinese Medicine in Multidrug-Resistant Bacterial Pneumonia

Sponsor: Henan University of Traditional Chinese Medicine

Summary

This is a multicenter prospective observational cohort study involving hospitalized adult patients with multidrug-resistant bacterial pneumonia. Patients will be categorized into two cohorts according to whether they receive systemic traditional Chinese medicine (TCM) treatment as part of routine clinical care. Systemic TCM treatment includes Chinese herbal decoctions, oral Chinese patent medicines, and Chinese medicine injections. Treatment decisions will be made by the attending physicians according to routine clinical practice, without intervention by the researchers. The primary objective is to evaluate the association between systemic TCM treatment and the occurrence of lower respiratory tract infection events within 90 days after hospital discharge. Secondary outcomes include all-cause and pneumonia-related mortality, rehospitalization, upper respiratory tract infection events, bacterial clearance, clinical cure at hospital discharge, antibacterial drug use, pneumonia-related clinician-reported and patient-reported outcomes, health-related quality of life, inflammatory markers, imaging changes, safety outcomes, and direct medical costs.

Official title: A Multicenter Prospective Observational Cohort Study of Traditional Chinese Medicine Treatment in Multidrug-Resistant Bacterial Pneumonia

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