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A Study to Evaluate the Efficacy and Safety of Tabirafusp Tedromer Compared to Aflibercept in Participants With DME - ALTO
Sponsor: Kodiak Sciences Inc
Summary
A Study to Evaluate the Efficacy and Safety of Tabirafusp Tedromer Compared to Aflibercept in Participants with Diabetic Macular Edema - ALTO
Official title: A Randomized, Double-masked, Active-controlled, Multi-center, Phase 3 Study to Evaluate the Efficacy and Safety of Intravitreal Tabirafusp Tedromer 5 mg Compared With Intravitreal Aflibercept 2 mg in Participants With Visual Impairment Secondary to Diabetic Macular Edema (DME) - ALTO
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
910
Start Date
2026-08-03
Completion Date
2029-09
Last Updated
2026-11-03
Healthy Volunteers
No
Conditions
Interventions
Tabirafusp tedromer
Intravitreal injection
Aflibercept (2.0 mg)
Intravitreal injection
Locations (52)
Kodiak Research Center
Scottsdale, Arizona, United States
Kodiak Research Center
Bakersfield, California, United States
Kodiak Research Center
Glendale, California, United States
Kodiak Research Center
Modesto, California, United States
Kodiak Research Center
Oxnard, California, United States
Kodiak Research Center
Pasadena, California, United States
Kodiak Research Center
Redlands, California, United States
Kodiak Research Center
Redlands, California, United States
Kodiak Research Center
Sacramento, California, United States
Kodiak Research Center
Sacramento, California, United States
Kodiak Research Center
Waterford, Connecticut, United States
Kodiak Research Center
Fort Lauderdale, Florida, United States
Kodiak Research Center
St. Petersburg, Florida, United States
Kodiak Research Center
Winter Haven, Florida, United States
Kodiak Research Center
Elmhurst, Illinois, United States
Kodiak Research Center
Hagerstown, Maryland, United States
Kodiak Research Center
Saint Louis Park, Minnesota, United States
Kodiak Research Center
Madison, Mississippi, United States
Kodiak Research Center
Hauppauge, New York, United States
Kodiak Research Center
Rochester, New York, United States
Kodiak Research Center
Cary, North Carolina, United States
Kodiak Research Center
Greensboro, North Carolina, United States
Kodiak Research Center
Hickory, North Carolina, United States
Kodiak Research Center
Wake Forest, North Carolina, United States
Kodiak Research Center
Winston-Salem, North Carolina, United States
Kodiak Research Center
Beaufort, South Carolina, United States
Kodiak Research Center
Charleston, South Carolina, United States
Kodiak Research Center
Ladson, South Carolina, United States
Kodiak Research Center
Mt. Pleasant, South Carolina, United States
Kodiak Research Center
West Columbia, South Carolina, United States
Kodiak Research Center
Sioux Falls, South Dakota, United States
Kodiak Research Center
Amarillo, Texas, United States
Kodiak Research Center
Arlington, Texas, United States
Kodiak Research Center
Austin, Texas, United States
Kodiak Research Center
Bellaire, Texas, United States
Kodiak Research Center
Fort Worth, Texas, United States
Kodiak Research Center
Katy, Texas, United States
Kodiak Research Center
Plano, Texas, United States
Kodiak Research Center
Round Rock, Texas, United States
Kodiak Research Center
San Antonio, Texas, United States
Kodiak Research Center
Schertz, Texas, United States
Kodiak Research Center
The Woodlands, Texas, United States
Kodiak Research Center
Lynchburg, Virginia, United States
Kodiak Research Center
Bellevue, Washington, United States
Kodiak Research Center
Caba, Buenos Aires, Argentina
Kodiak Research Center
Caba, Buenos Aires, Argentina
Kodiak Research Center
Caba, Buenos Aires, Argentina
Kodiak Research Center
Caba, Buenos Aires, Argentina
Kodiak Research Center
Comodoro Rivadavia, Chubut Province, Argentina
Kodiak Research Center
Mendoza, Mendoza Province, Argentina
Kodiak Research Center
Rosario, Santa Fe Province, Argentina
Kodiak Research Center
Rosario, Santa Fe Province, Argentina