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A Study to Investigate Outcomes With Elecoglipron Compared With Placebo in Adult Participants With Chronic Kidney Disease.
Sponsor: AstraZeneca
Summary
This is a Phase III, randomized, double-blind, parallel-group, placebo-controlled multicenter study to investigate outcomes with elecoglipron compared with placebo in participants with CKD with and without T2DM who are on background SGLT2i (dapagliflozin) as GDMT and other SoC treatments for CKD.
Official title: A Phase III, Randomized, Double-blind, Parallel-group, Placebo-controlled Multicenter Study to Evaluate the Effect of Elecoglipron in Reducing Renal Outcomes and Mortality in Participants With Chronic Kidney Disease (Elevate-CKD)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
7000
Start Date
2026-08-21
Completion Date
2030-10-04
Last Updated
2026-09-09
Healthy Volunteers
No
Conditions
Interventions
Elecoglipron
Elicoglipron tablet
Placebo
Placebo tablet
Locations (715)
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Huntsville, Alabama, United States
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Montgomery, Alabama, United States
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Sheffield, Alabama, United States
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Peoria, Arizona, United States
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Phoenix, Arizona, United States
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Surprise, Arizona, United States
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Little Rock, Arkansas, United States
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Chula Vista, California, United States
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Concord, California, United States
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Daly City, California, United States
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Fremont, California, United States
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Huntington Beach, California, United States
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Huntington Park, California, United States
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Lomita, California, United States
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National City, California, United States
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Northridge, California, United States
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Northridge, California, United States
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Rolling Hills Estates, California, United States
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San Diego, California, United States
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San Francisco, California, United States
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San Mateo, California, United States
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Tarzana, California, United States
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Arvada, Colorado, United States
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Denver, Colorado, United States
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Hartford, Connecticut, United States
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Middlebury, Connecticut, United States
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Waterbury, Connecticut, United States
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Boca Raton, Florida, United States
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Boynton Beach, Florida, United States
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Cutler Bay, Florida, United States
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Fort Lauderdale, Florida, United States
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Hollywood, Florida, United States
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Jacksonville Beach, Florida, United States
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Jensen Beach, Florida, United States
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Lauderdale Lakes, Florida, United States
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Longwood, Florida, United States
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Melbourne, Florida, United States
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Miami, Florida, United States
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Miami, Florida, United States
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Ocoee, Florida, United States
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Orlando, Florida, United States
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Pensacola, Florida, United States
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Port Charlotte, Florida, United States
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Riverview, Florida, United States
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Austell, Georgia, United States
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Columbus, Georgia, United States
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East Point, Georgia, United States
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Tucker, Georgia, United States
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Champaign, Illinois, United States
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Chicago, Illinois, United States
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Chicago, Illinois, United States
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Rockford, Illinois, United States
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Tinley Park, Illinois, United States
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Ames, Iowa, United States
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Topeka, Kansas, United States
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Beltsville, Maryland, United States
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Boston, Massachusetts, United States
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New Bedford, Massachusetts, United States
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Detroit, Michigan, United States
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Flint, Michigan, United States
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Saginaw, Michigan, United States
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Saint Joseph, Michigan, United States
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Southfield, Michigan, United States
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Troy, Michigan, United States
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Minneapolis, Minnesota, United States
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Minneapolis, Minnesota, United States
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Brookhaven, Mississippi, United States
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Chesterfield, Missouri, United States
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Las Vegas, Nevada, United States
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Las Vegas, Nevada, United States
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Las Vegas, Nevada, United States
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Eatontown, New Jersey, United States
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Jersey City, New Jersey, United States
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Albuquerque, New Mexico, United States
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Albany, New York, United States
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Brooklyn, New York, United States
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Buffalo, New York, United States
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Mineola, New York, United States
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Greensboro, North Carolina, United States
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Morehead City, North Carolina, United States
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Rocky Mount, North Carolina, United States
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Shelby, North Carolina, United States
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Statesville, North Carolina, United States
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Wilmington, North Carolina, United States
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Wilmington, North Carolina, United States
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Cincinnati, Ohio, United States
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Maumee, Ohio, United States
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Portland, Oregon, United States
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Beaver, Pennsylvania, United States
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Exton, Pennsylvania, United States
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Indiana, Pennsylvania, United States
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Media, Pennsylvania, United States
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Philadelphia, Pennsylvania, United States
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Plymouth Meeting, Pennsylvania, United States
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East Providence, Rhode Island, United States
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Providence, Rhode Island, United States
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Rapid City, South Dakota, United States
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Knoxville, Tennessee, United States
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Morristown, Tennessee, United States
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Arlington, Texas, United States