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Feasibility and Uptake of Low-Dose CT Lung Cancer Screening in Kuwait
Sponsor: Sulaiman Khadadah
Summary
Lung cancer is a leading cause of cancer-related death in Kuwait, where most cases are diagnosed at an advanced stage and there is no national screening program. This prospective pilot feasibility study offers low-dose computed tomography (LDCT) screening to high-risk individuals aged 50-80 years (about 590 participants, so that about 500 complete a baseline scan), recruited by physicians at Ministry of Health polyclinics and hospital chest clinics and screened at the Chest Diseases Hospital. The primary objective is to assess the uptake of, and barriers to, LDCT lung cancer screening in Kuwait and to establish a framework for a national screening program. Participants undergo eligibility assessment (smoking history of at least 20 pack-years, totalled across all smoked tobacco products using pre-specified equivalency conversions for shisha/waterpipe, cigar, pipe, and roll-your-own tobacco), baseline assessment, and are offered three LDCT screening rounds (a baseline scan and two annual rounds) with Lung-RADS-based management and follow-up. Scans are read by radiologists without artificial intelligence (AI); at the end of the study, AI software is run once on the archived scans in a separate reader study. Findings will inform national lung cancer screening guidelines for Kuwait.
Official title: ALIA Kuwait: A Prospective Pilot Feasibility Study of Low-Dose Computed Tomography Screening for Lung Cancer in High-Risk Individuals in Kuwait
Key Details
Gender
All
Age Range
50 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
590
Start Date
2026-09-01
Completion Date
2029-08-31
Last Updated
2026-11-03
Healthy Volunteers
Yes
Conditions
Interventions
Low-dose computed tomography (LDCT) lung cancer screening
Low-dose chest CT without contrast, reported by a radiologist using Lung-RADS v2022, without AI. Management and follow-up intervals follow the Lung-RADS category (annual repeat for 1-2; short-interval CT at 6 months for 3 and 3 months for 4A; diagnostic work-up and multidisciplinary team referral for 4B/4X). Incidental findings (Lung-RADS modifier S) are managed at the results consultation by referral, advice or no action, according to the study's threshold-based referral routing table. At the end of the study, AI software (AVIEW LCS+, Coreline Soft) is run once on the archived scans, with one fixed software version, in a separate reader study; AI output is not used in clinical care.
Locations (1)
Lung Cancer Screening Clinic, Chest Diseases Hospital
Kuwait City, Kuwait