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A Study of Raludotatug Deruxtecan With or Without Bevacizumab as First-Line Maintenance Treatment in Non-HRD-Positive Advanced Ovarian Cancer (MK-5909-006, (ENGOT-ov102/GOG-3141/ REJOICE-Ovarian 04)
Sponsor: Merck Sharp & Dohme LLC
Summary
Researchers are looking for new ways to treat ovarian cancer (OC). Current treatment for OC may start with surgery to remove as much of the cancer as possible. After surgery, people may receive chemotherapy. After chemotherapy, standard care options may include: Maintenance treatment, which is used after another therapy to keep the cancer from growing, spreading, or coming back. Bevacizumab is a targeted therapy used as standard maintenance treatment. Targeted therapy works to control how specific types of cancer cells grow and spread. Observation, which is watching to see if cancer grows or worsens. The study medicine, raludotatug deruxtecan- R-DXd, is a targeted therapy. The goal of this study is to learn if people who receive R-DXd maintenance treatment with or without bevacizumab live longer without the cancer getting worse than people who receive standard care.
Official title: A Phase 3, Randomized, Open-label Study of Raludotatug Deruxtecan (MK-5909, R-DXd) Maintenance Treatment With or Without Bevacizumab Versus Standard of Care in Participants With Newly-Diagnosed Advanced Non-HRD-Positive Ovarian Cancer Following First-line Platinum-based Chemotherapy (ENGOT-ov102/MITO/GOG-3141/ REJOICE-Ovarian 04)
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
802
Start Date
2026-09-18
Completion Date
2034-10-22
Last Updated
2026-10-29
Healthy Volunteers
No
Interventions
R-DXd
R-DXd administered as an intravenously (IV) infusion
Bevacizumab
Administered as an intravenously IV infusion
Locations (11)
MedStar Washington Hospital Center ( Site 0026)
Washington D.C., District of Columbia, United States
Lahey Hospital & Medical Center ( Site 0031)
Burlington, Massachusetts, United States
Oncology Associates of Oregon, P.C.(Willamette Valley Cancer Institute) (WVCI) ( Site 8000)
Eugene, Oregon, United States
Texas Oncology - Central/South Texas ( Site 8002)
Austin, Texas, United States
Texas Oncology - DFW ( Site 8005)
Fort Worth, Texas, United States
Texas Oncology - Northeast Texas ( Site 8004)
Tyler, Texas, United States
Rambam Health Care Campus ( Site 1402)
Haifa, Israel
Sourasky Medical Center ( Site 1403)
Tel Aviv, Israel
Seoul National University Hospital ( Site 2301)
Seoul, South Korea
Samsung Medical Center ( Site 2303)
Seoul, South Korea
National Cheng Kung University Hospital ( Site 2601)
Tainan, Taiwan