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A Study to Evaluate Effect of AZD6234 in Adult Participants With Type 2 Diabetes Mellitus and Obesity or Overweight
Sponsor: AstraZeneca
Summary
The study will evaluate how well AZD6234 works and how safe it is in adults with excess weight or obesity. Efficacy of AZD6234 will be compared to placebo in percent body weight change from baseline at 68 weeks of treatment
Official title: A Phase III Randomized, Double-Blind, Placebo-Controlled Multicentre Trial to Evaluate the Efficacy and Safety of AZD6234 in Participants With Type 2 Diabetes Mellitus and Obesity or Overweight (SELENE 2)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
1500
Start Date
2026-08-20
Completion Date
2028-08-09
Last Updated
2026-10-28
Healthy Volunteers
No
Interventions
Lenbelintide
IMP injected subcutaneously, once a week. Unit dose strength as per CSP.
Placebo
Placebo matching IMP dose injected subcutaneously, once a week.
Locations (230)
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Fairhope, Alabama, United States
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Huntsville, Alabama, United States
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Mobile, Alabama, United States
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Mesa, Arizona, United States
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Phoenix, Arizona, United States
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Tucson, Arizona, United States
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Little Rock, Arkansas, United States
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Bakersfield, California, United States
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Gardena, California, United States
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Lincoln, California, United States
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Torrance, California, United States
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Walnut Creek, California, United States
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Doral, Florida, United States
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Fleming Island, Florida, United States
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Fort Lauderdale, Florida, United States
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Ocoee, Florida, United States
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Woodstock, Georgia, United States
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Chicago, Illinois, United States
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Melrose Park, Illinois, United States
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Oak Brook, Illinois, United States
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Ames, Iowa, United States
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Lenexa, Kansas, United States
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Newton, Kansas, United States
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Monroe, Louisiana, United States
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Beltsville, Maryland, United States
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Lanham, Maryland, United States
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Oxon Hill, Maryland, United States
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Rockville, Maryland, United States
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North Dartmouth, Massachusetts, United States
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Farmington Hills, Michigan, United States
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Fayette, Mississippi, United States
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Kansas City, Missouri, United States
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Kansas City, Missouri, United States
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St Louis, Missouri, United States
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Omaha, Nebraska, United States
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Omaha, Nebraska, United States
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Eatontown, New Jersey, United States
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Somerset, New Jersey, United States
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Warren Township, New Jersey, United States
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Greensboro, North Carolina, United States
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Monroe, North Carolina, United States
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Stow, Ohio, United States
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Scottdale, Pennsylvania, United States
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Franklin, Tennessee, United States
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Jackson, Tennessee, United States
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Knoxville, Tennessee, United States
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DeSoto, Texas, United States
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El Paso, Texas, United States
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Houston, Texas, United States
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Midland, Texas, United States
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Pasadena, Texas, United States
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San Antonio, Texas, United States
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San Antonio, Texas, United States
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San Antonio, Texas, United States
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Manassas, Virginia, United States
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Norfolk, Virginia, United States
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Buenos Aires, Argentina
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CABA, Argentina
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Ciudad de Buenos Aires, Argentina
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Mendoza, Argentina
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Ramos Mejía, Argentina
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Rosario, Argentina
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San Nicolás, Argentina
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Botany, Australia
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Camberwell, Australia
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Charlestown, Australia
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Helensvale, Australia
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Maroubra, Australia
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Waitara, Australia
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Calgary, Alberta, Canada
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Vancouver, British Columbia, Canada
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Moncton, New Brunswick, Canada
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Truro, Nova Scotia, Canada
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Hamilton, Ontario, Canada
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Markham, Ontario, Canada
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North York, Ontario, Canada
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Sarnia, Ontario, Canada
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Scarborough Village, Ontario, Canada
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Stoney Creek, Ontario, Canada
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Stouffville, Ontario, Canada
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Toronto, Ontario, Canada
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Toronto, Ontario, Canada
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Joliette, Quebec, Canada
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Montreal, Quebec, Canada
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Montreal, Quebec, Canada
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Québec, Quebec, Canada
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Trois-Rivières, Quebec, Canada
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Concepción, Chile
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Concepción, Chile
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Concepción, Chile
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Iquique, Chile
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Las Condes, Chile
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Providencia, Chile
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Santiago, Chile
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Santiago, Chile
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Santiago, Chile
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Beijing, China
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Cangzhou, China
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Changchun, China
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Chengdu, China