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A Study to Evaluate Effect of AZD6234 in Adult Participants With Obesity or Overweight With Weight-related Comorbidity Without Type 2 Diabetes Mellitus
Sponsor: AstraZeneca
Summary
The study will evaluate how well AZD6234 works and how safe it is in adults with excess weight or obesity. Efficacy of AZD6234 will be compared to placebo in percent body weight change from baseline at 68 weeks of treatment
Official title: A Phase III Randomised, Double-Blind, Placebo-Controlled Multicentre Trial to Evaluate the Efficacy and Safety of AZD6234 in Participants With Obesity or Overweight With at Least One Weight-Related Comorbidity Without Type 2 Diabetes Mellitus (SELENE 1)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
2500
Start Date
2026-08-19
Completion Date
2029-05-21
Last Updated
2026-10-30
Healthy Volunteers
No
Conditions
Interventions
Lenbelintide
IMP injected subcutaneously, once a week. Unit dose strength as per CSP.
Placebo
Placebo matching IMP dose injected subcutaneously, once a week.
Locations (220)
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Dothan, Alabama, United States
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Huntsville, Alabama, United States
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Mesa, Arizona, United States
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Escondido, California, United States
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Bridgeport, Connecticut, United States
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Clearwater, Florida, United States
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Jacksonville, Florida, United States
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Stockbridge, Georgia, United States
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Champaign, Illinois, United States
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Chicago, Illinois, United States
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Ames, Iowa, United States
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El Dorado, Kansas, United States
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Owensboro, Kentucky, United States
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Troy, Michigan, United States
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Jefferson City, Missouri, United States
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Kansas City, Missouri, United States
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Butte, Montana, United States
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Las Vegas, Nevada, United States
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Jersey City, New Jersey, United States
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Cortland, New York, United States
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Rochester, New York, United States
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Rocky Mount, North Carolina, United States
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Statesville, North Carolina, United States
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Wilmington, North Carolina, United States
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Fargo, North Dakota, United States
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Columbus, Ohio, United States
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Maumee, Ohio, United States
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Tulsa, Oklahoma, United States
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Portland, Oregon, United States
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Philadelphia, Pennsylvania, United States
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Smithfield, Pennsylvania, United States
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Kingsport, Tennessee, United States
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Memphis, Tennessee, United States
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Houston, Texas, United States
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San Antonio, Texas, United States
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Sugar Land, Texas, United States
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Waco, Texas, United States
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Salt Lake City, Utah, United States
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Arlington, Virginia, United States
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Renton, Washington, United States
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Seattle, Washington, United States
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Buenos Aires, Argentina
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Buenos Aires, Argentina
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Ciudad de Buenos Aires, Argentina
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Mendoza, Argentina
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Ramos Mejía, Argentina
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Rosario, Argentina
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San Nicolás, Argentina
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Botany, Australia
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Camberwell, Australia
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Charlestown, Australia
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St Albans, Australia
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St Leonards, Australia
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Waitara, Australia
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Belo Horizonte, Brazil
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Brasília, Brazil
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Campinas, Brazil
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Campinas, Brazil
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Curitiba, Brazil
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Curitiba, Brazil
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Curitiba, Brazil
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Natal, Brazil
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Porto Alegre, Brazil
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Rio de Janeiro, Brazil
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São José dos Campos, Brazil
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São Paulo, Brazil
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Montana, Bulgaria
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Pleven, Bulgaria
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Plovdiv, Bulgaria
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Sofia, Bulgaria
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Sofia, Bulgaria
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Sofia, Bulgaria
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Varna, Bulgaria
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Yambol, Bulgaria
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Calgary, Alberta, Canada
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New Westminster, British Columbia, Canada
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Surrey, British Columbia, Canada
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Victoria, British Columbia, Canada
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Moncton, New Brunswick, Canada
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Truro, Nova Scotia, Canada
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Brampton, Ontario, Canada
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Guelph, Ontario, Canada
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Hamilton, Ontario, Canada
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Mississauga, Ontario, Canada
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North York, Ontario, Canada
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Scarborough Village, Ontario, Canada
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Stoney Creek, Ontario, Canada
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Stouffville, Ontario, Canada
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Toronto, Ontario, Canada
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Montreal, Quebec, Canada
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Québec, Quebec, Canada
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Québec, Quebec, Canada
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Saint-Charles-Borromée, Quebec, Canada
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Sherbrooke, Quebec, Canada
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Beijing, China
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Cangzhou, China
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Changchun, China
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Changchun, China
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Changsha, China
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Chengdu, China